{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T14:11:03Z","timestamp":1682604663903},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"815","license":[{"start":{"date-parts":[[1993,9,1]],"date-time":"1993-09-01T00:00:00Z","timestamp":746841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>During the year 1991, 43 patients with upper gastrointestinal bleeding and one with severe epigastric pain associated with intake of non-steroidal anti-inflammatory drugs were admitted for emergency endoscopy to our unit. Fourteen patients (33%) had been treated with 100-325 mg aspirin daily, 11 of them for at least one year. The mean age of this group was 71. Only two patients had a previous history of peptic ulcer. Five patients used anticoagulants or antiplatelet drugs concomitantly with aspirin. The endoscopic diagnosis of the sources of bleeding was erosive gastritis in eight patients, gastric ulcer in four, duodenal ulcer in five and oesophageal ulcer in one. Our results support findings by other groups, showing that doses of aspirin as low as 75 mg daily should be used in the management of elderly patients with thrombo-embolic disease.<\/jats:p>","DOI":"10.1136\/pgmj.69.815.712","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"712-714","source":"Crossref","is-referenced-by-count":2,"title":["Gastro-duodenal injury associated with intake of 100-325 mg aspirin daily"],"prefix":"10.1093","volume":"69","author":[{"given":"Ran","family":"Oren","sequence":"first","affiliation":[{"name":"Gastroenterology Service, Hadassah University Hospital , Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Ligumsky","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Hadassah University Hospital , Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Lysy","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Hadassah University Hospital , Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Hadassah University Hospital , Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Hadassah University Hospital , Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/bmj.280.6207.75","article-title":"Gastroscopic evaluation of anti-inflammatory agents","volume":"280","author":"Caruso, I.; Bianchi Porro, G.","year":"1980","unstructured":"Caruso, I. & Bianchi Porro, G. Gastroscopic evaluation of anti-inflammatory agents. Br Med J 1980, 280: 75-78.","journal-title":"Br Med J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(86)92927-2","article-title":"Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer","volume":"i:","author":"Somerville, K.; Faulkner, G.; Langman, M.","year":"1986","unstructured":"Somerville, K., Faulkner, G. & Langman, M. Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986, i: 462-464.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/gut.28.5.527","article-title":"Non-steroidal antiinflammatory drugs and life threatening complications of peptic ulceration","volume":"28","author":"Armstrong, C.P.; Blower, A.L.","year":"1987","unstructured":"Armstrong, C.P. & Blower, A.L. Non-steroidal antiinflammatory drugs and life threatening complications of peptic ulceration. Gut 1987, 28: 527-532.","journal-title":"Gut"},{"issue":"390-398","key":"ref_4","first-page":"714","article-title":"Aspirin and the stomach (review)","volume":"104","author":"Graham, D.Y.; Smith, J.L.","unstructured":"Graham, D.Y. & Smith, J.L. Aspirin and the stomach (review). Ann Intern Med 1986, 104: 390-398. 714 R. OREN et al.","journal-title":"Ann Intern Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00004836-199002000-00004","article-title":"Frequency of gastroduodenal lesions in asymptomatic patients on chronic aspirin or nonsteroidal antiinflammatory drug therapy","volume":"12","author":"Jaszewsky, R.","year":"1990","unstructured":"Jaszewsky, R. Frequency of gastroduodenal lesions in asymptomatic patients on chronic aspirin or nonsteroidal antiinflammatory drug therapy. 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Dig Dis Sci 1983, 28: 1-6.","journal-title":"Dig Dis Sci"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1445-5994.1977.tb02315.x","article-title":"The effects of enteric coating of aspirin tablets on occult gastrointestinal blood loss","volume":"7","author":"Howe, G.B.; Champion, G.D.; Corrigan, A.B.","year":"1977","unstructured":"Howe, G.B., Champion, G.D., Corrigan, A.B. et al. The effects of enteric coating of aspirin tablets on occult gastrointestinal blood loss. Aust NZ J Med 1977, 7: 600-604.","journal-title":"Aust NZ J Med"},{"key":"ref_11","first-page":"609","article-title":"Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man","volume":"1","author":"Hoftiezer, J.W.; Silvoso, G.R.; Burks, M.; Ivey, K.J.","year":"1980","unstructured":"Hoftiezer, J.W., Silvoso, G.R., Burks, M. & Ivey, K.J. Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man. 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Gastroenterology 1990, 98(6): 1549-1557.","journal-title":"Gastroenterology"},{"issue":"31","key":"ref_16","first-page":"192","article-title":"Bioavailability of aspirin after oral and rectal administration in volunteers and patients with fever","volume":"1985","author":"Dalvi, S.S.; Gupta, K.C.; Pohujani, S.M.; Vaidya, A.B.; Satoskar, R.S.","unstructured":"Dalvi, S.S., Gupta, K.C., Pohujani, S.M., Vaidya, A.B. & Satoskar, R.S. Bioavailability of aspirin after oral and rectal administration in volunteers and patients with fever. J Postgrad Med 1985, 31: 192-195.","journal-title":"J Postgrad Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/adc.54.9.713","article-title":"Rectal aspirin absorption and antipyretic effect","volume":"54","author":"Connolly, K.; Lam, L.; Ward, O.C.","year":"1979","unstructured":"Connolly, K., Lam, L. & Ward, O.C. Rectal aspirin absorption and antipyretic effect. Arch Dis Child 1979, 54: 713-715.","journal-title":"Arch Dis Child"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM198908103210604","article-title":"Effect oflow-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension","volume":"321","author":"Benigni, A.; Gregorini, G.; Frusca, T.","year":"1989","unstructured":"Benigni, A., Gregorini, G., Frusca, T. et al. Effect oflow-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. N Engl J Med 1989, 321: 357-362.","journal-title":"N Engl J Med"},{"key":"ref_19","first-page":"117","article-title":"US Preventive Services Task Force. Aspirin prophylaxis for cardiovascular disease","volume":"40","year":"1989","unstructured":"US Preventive Services Task Force. Aspirin prophylaxis for cardiovascular disease. Am Fam Physician 1989, 40: 117-120.","journal-title":"Am Fam Physician"},{"issue":"298","key":"ref_20","first-page":"493","article-title":"Human gastric mucosal bleeding induced by low dose aspirin but not warfarin","volume":"1985","author":"Prichard, P.J.; Mitchingam, G.M.; Walt, R.P.","unstructured":"Prichard, P.J., Mitchingam, G.M., Walt, R.P. et al. Human gastric mucosal bleeding induced by low dose aspirin but not warfarin. Br Med J 1985, 298: 493-496.","journal-title":"Br Med J"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/j.1552-4604.1984.tb02770.x","article-title":"A controlled endoscopic study comparing the toxic effects of sulindac, naproxen, aspirin, and placebo on the gastric mucosa of healthy volunteers","volume":"24","author":"Lanza, F.L.; Nelson, R.S.; Rack, M.F.","year":"1984","unstructured":"Lanza, F.L., Nelson, R.S. & Rack, M.F. A controlled endoscopic study comparing the toxic effects of sulindac, naproxen, aspirin, and placebo on the gastric mucosa of healthy volunteers. J Clin Pharmacol 1984, 24: 89-95.","journal-title":"J Clin Pharmacol"},{"key":"ref_22","first-page":"211","article-title":"Effect of aspirin on the human stomach in normals: endoscopic comparison of damage produced one hour, 24 hours, and 2 weeks after administration","volume":"67","author":"O'Laughlin, J.C.; Hoftiezer, J.W.; Ivey, K.J.","year":"1981","unstructured":"O'Laughlin, J.C., Hoftiezer, J.W. & Ivey, K.J. Effect of aspirin on the human stomach in normals: endoscopic comparison of damage produced one hour, 24 hours, and 2 weeks after administration. Scand J Gastroenterol 1981, 67(Suppl): 211-214.","journal-title":"Scand J Gastroenterol"},{"key":"ref_23","first-page":"17","article-title":"A comparative endoscopic evaluation of the damaging effects of nonsteroidal antiinflammatory agents on the gastric and duodenal mucosa","volume":"75","author":"Lanza, F.L.; Royer, G.L.; Nelson, R.S.; Chen, T.T.; Seckman, C.E.; Rack, M.F.","year":"1981","unstructured":"Lanza, F.L., Royer, G.L., Nelson, R.S., Chen, T.T., Seckman, C.E. & Rack, M.F. A comparative endoscopic evaluation of the damaging effects of nonsteroidal antiinflammatory agents on the gastric and duodenal mucosa. Am J Gastroenterol 1981, 75: 17-21.","journal-title":"Am J Gastroenterol"},{"issue":"80","key":"ref_24","first-page":"767","article-title":"and the gastroduodenal mucosa: an endoscopic assessment","volume":"1985","author":"Lanza, F.L.; Royer, G.L.; Nelson, R.S.; Rack, M.F.; Seckman, C.C.Ethanol; aspirin, ibuprofen","unstructured":"Lanza, F.L., Royer, G.L., Nelson, R.S., Rack, M.F. & Seckman, C.C. Ethanol, aspirin, ibuprofen, and the gastroduodenal mucosa: an endoscopic assessment. Am J Gastroenterol 1985, 80: 767-769.","journal-title":"Am J Gastroenterol"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0002-9343(84)80014-5","article-title":"Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents","volume":"16","author":"Lanza, F.L.","year":"1984","unstructured":"Lanza, F.L. Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents. Am J Med 1984, 16: 19-24.","journal-title":"Am J Med"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1055\/s-0038-1646599","article-title":"Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis - effect of low-dose aspirin","volume":"61","author":"Kyrle, P.A.; Minar, E.; Brenner, B.","year":"1989","unstructured":"Kyrle, P.A., Minar, E., Brenner, B. et al. Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis - effect of low-dose aspirin. Thromb Haemost 1989, 61: 374-377.","journal-title":"Thromb Haemost"},{"key":"ref_27","first-page":"317","article-title":"Role of endogenous prostaglandins in gastric mucosal integrity","volume-title":"Mechanism of Mucosal Protection in the Upper Gastrointestinal Tract","author":"Kauffman, Jr, G.L.; Ligumsky, M.","year":"1984","unstructured":"Kauffman, G.L., Jr & Ligumsky, M. Role of endogenous prostaglandins in gastric mucosal integrity. In: Allen, A. et al. (eds) Mechanism of Mucosal Protection in the Upper Gastrointestinal Tract. Raven Press, New York, 1984, pp. 317-322."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0016-5085(90)90816-J","article-title":"Aspirin-induced changes in gastric function: role of endogenous prostaglandins and mucosal damage","volume":"98","author":"Shea-Donohue, T.; Steel, L.; Montcalm-Mazzilli, E.; Dubois, A.","year":"1990","unstructured":"Shea-Donohue, T., Steel, L., Montcalm-Mazzilli, E. & Dubois, A. Aspirin-induced changes in gastric function: role of endogenous prostaglandins and mucosal damage. Gastroenterology 1990, 98: 284-292.","journal-title":"Gastroenterology"},{"issue":"146","key":"ref_29","first-page":"921","article-title":"Lowvs high-dose aspirin: effects on platelet function in hyperlipoproteiemic and normal subjects","volume":"1986","author":"Zucker, M.L.; Trowbridge, C.; Woodroof, J.; Chernoff, S.B.; Reynoso, L.; Dujovne, C.A.","unstructured":"Zucker, M.L., Trowbridge, C., Woodroof, J., Chernoff, S.B., Reynoso, L. & Dujovne, C.A. Lowvs high-dose aspirin: effects on platelet function in hyperlipoproteiemic and normal subjects. 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