{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:23Z","timestamp":1761058883398},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"817","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role for such cytokine therapy in patients with life-threatening agranulocytosis in order to speed the recovery of neutrophils.<\/jats:p>","DOI":"10.1136\/pgmj.69.817.885","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"885-887","source":"Crossref","is-referenced-by-count":8,"title":["First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases"],"prefix":"10.1093","volume":"69","author":[{"given":"J R","family":"Kendra","sequence":"first","affiliation":[{"name":"Burnley General Hospital , Burnley"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F P","family":"Rugman","sequence":"additional","affiliation":[{"name":"Preston Royal Infirmary , Preston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T A","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Preston Royal Infirmary , Preston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Myers","sequence":"additional","affiliation":[{"name":"Blackburn Royal Infirmary , Blackburn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Horsfield","sequence":"additional","affiliation":[{"name":"Blackburn Royal Infirmary , Blackburn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Barton","sequence":"additional","affiliation":[{"name":"Blackburn Royal Infirmary , Blackburn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Russell","sequence":"additional","affiliation":[{"name":"Amgen (UK) Limited , 240 Cambridge Science Park, Milton Road, Cambridge CB4 4WD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,11,1]]},"reference":[{"key":"ref_1","article-title":"Adverse Drug Reactions 1963-1992","author":"Medicines Control Agency (UK","unstructured":"Medicines Control Agency (UK). Adverse Drug Reactions 1963-1992."},{"issue":"31","key":"ref_2","first-page":"52","article-title":"Drug-induced aplastic anaemia and agranulocytosis: incidence and mechanisms","volume":"1986","author":"Vincent, P.C.","unstructured":"Vincent, P.C. Drug-induced aplastic anaemia and agranulocytosis: incidence and mechanisms. Drugs 1986, 31: 52-63.","journal-title":"Drugs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1056\/NEJM199107183250305","article-title":"el al. Reduction by granulocyte colony stimulating factor of fever and neutropenia induced by chemotherapy in patients with small cell lung cancer","volume":"325","author":"Crawford, J.; Ozer, H.; Stoller, R.","year":"1991","unstructured":"Crawford, J., Ozer, H., Stoller, R. el al. Reduction by granulocyte colony stimulating factor of fever and neutropenia induced by chemotherapy in patients with small cell lung cancer. 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Lancet 1992, 340: 1097.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2141.1992.tb04574.x","article-title":"Successful treatment of clozapine induced agranulocytosis with G-CSF","volume":"80","author":"Weide, R.; Koppler, H.; Heymanns, J.; Pfluger, K.H.; Havemann, K.","year":"1992","unstructured":"Weide, R., Koppler, H., Heymanns, J., Pfluger, K.H. & Havemann, K. Successful treatment of clozapine induced agranulocytosis with G-CSF. Br J Haematol 1992, 80: 557-559.","journal-title":"Br J Haematol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2141.1992.tb04578.x","article-title":"Accelerated recovery from drug induced agranulocytosis following G-CSF therapy","volume":"80","author":"Patton, W.N.; Holyoake, T.L.; Yates, J.M.; Boughton, B.J.; Franklin, I.M.","year":"1992","unstructured":"Patton, W.N., Holyoake, T.L., Yates, J.M., Boughton, B.J. & Franklin, I.M. Accelerated recovery from drug induced agranulocytosis following G-CSF therapy. Br J Haematol 1992, 80: 564-565.","journal-title":"Br J Haematol"},{"key":"ref_9","first-page":"887","volume":"69","author":"J, Postgrad Med","year":"1993","unstructured":"Postgrad Med J (1993) 69, 887-889"},{"key":"ref_10","article-title":"The Fellowship of Postgraduate","year":"1993","unstructured":"\u00a9 The Fellowship of Postgraduate Medicine, 1993","journal-title":"Medicine"},{"key":"ref_11","article-title":"failure, bilateral lower leg ulceration, hyperuricaemia and poor mobility due to osteoarthritis. Her daily medication included","volume-title":"80 mg, allopurinol 100 mg, quinine sulphate 300 mg and co-codamol (paracetamol and codeine) as required for pain","year":"1993","unstructured":"Correspondence: N.R. Colledge, B.Sc., M.R.C.P. *Present address: Dryburn Hospital, Durham, UK. 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Her daily medication included spironolactone 200 mg, frusemide 80 mg, allopurinol 100 mg, quinine sulphate 300 mg and co-codamol (paracetamol and codeine) as required for pain."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/69\/817\/885\/50073266\/postgradmedj-69-885.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/69\/817\/885\/50073266\/postgradmedj-69-885.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T13:48:41Z","timestamp":1682603321000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/69\/817\/885\/7063035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11,1]]},"references-count":11,"journal-issue":{"issue":"817","published-online":{"date-parts":[[1993,11,1]]},"published-print":{"date-parts":[[1993,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.69.817.885","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1993,11]]},"published":{"date-parts":[[1993,11,1]]}}}