{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:10:39Z","timestamp":1684149039711},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"819","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two patients with Graves' disease were incidentally found to have anti-mitochondrial antibodies by immunofluorescence in the absence of symptoms, clinical signs or biochemical evidence of liver dysfunction. Anti-mitochondrial antibody titres became undetectable in both patients on follow-up. Screening of the patients' sera by immunoblotting against the purified antigens of the M2 complex was negative. We conclude that in these cases, anti-mitochondrial antibodies detected by immunofluorescence were directed against antigens other than the primary biliary cirrhosis-associated M2 complex and therefore did not signify subclinical primary biliary cirrhosis.<\/jats:p>","DOI":"10.1136\/pgmj.70.819.17","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"17-18","source":"Crossref","is-referenced-by-count":0,"title":["Anti-mitochondrial antibodies in patients with Graves' disease may not signify primary biliary cirrhosis"],"prefix":"10.1093","volume":"70","author":[{"given":"P","family":"Perros","sequence":"first","affiliation":[{"name":"Department of Medicine, Medical School, University of Newcastle upon Tyne , Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Newcastle upon Tyne , Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Yeaman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Newcastle upon Tyne , Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Kendall-Taylor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical School, University of Newcastle upon Tyne , Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJM198702263160907","article-title":"Primary biliary cirrhosis","volume":"316","author":"Kaplan, M.M.","year":"1987","unstructured":"Kaplan, M.M. Primary biliary cirrhosis. N Engl J Med 1987, 316: 521-528.","journal-title":"N Engl J Med"},{"issue":"85","key":"ref_2","first-page":"8654","article-title":"Identification and analysis of the major M2 antigens in primary biliary cirrhosis","volume":"1988","author":"Fussey, S.P.M.; Guest, J.R.; James, O.F.W.; Bassendine, M.F.; Yeaman, S.J.","unstructured":"Fussey, S.P.M., Guest, J.R., James, O.F.W., Bassendine, M.F. & Yeaman, S.J. Identification and analysis of the major M2 antigens in primary biliary cirrhosis. Proc Natl Acad Sci USA 1988, 85: 8654-8658.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"ref_3","first-page":"1279","article-title":"Positive antimitochondrial antibody but normal alkaline phosphatase: is it primary biliary cirrhosis?","volume":"1986","author":"Mitchison, H.C.; Bassendine, M.F.; Hendrick, A.","unstructured":"Mitchison, H.C., Bassendine, M.F., Hendrick, A. et al. Positive antimitochondrial antibody but normal alkaline phosphatase: is it primary biliary cirrhosis? Hepatology 1986, 6: 1279-1284.","journal-title":"Hepatology"},{"key":"ref_4","first-page":"1498","article-title":"Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins","volume":"3","author":"Zarrilli, R.; Oates, E.L.; McBride, O.W.","year":"1989","unstructured":"Zarrilli, R., Oates, E.L., McBride, O.W. et al. Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. Mot Endocrinol 1989, 3: 1498-1508.","journal-title":"Mot Endocrinol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/0016-5085(90)90488-M","article-title":"Primary biliary cirrhosis: quantitation of autoantibodies to purified mitochondrial enzymes and correlation with disease progression","volume":"99","author":"Heseltine, L.; Turner, I.B.; Fussey, S.P.M.","year":"1990","unstructured":"Heseltine, L., Turner, I.B., Fussey, S.P.M. et al. Primary biliary cirrhosis: quantitation of autoantibodies to purified mitochondrial enzymes and correlation with disease progression. Gastroenterology 1990, 99: 1786-1792.","journal-title":"Gastroenterology"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/819\/17\/50217543\/postgradmedj-70-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/819\/17\/50217543\/postgradmedj-70-17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:45:36Z","timestamp":1684147536000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/70\/819\/17\/7042427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1,1]]},"references-count":5,"journal-issue":{"issue":"819","published-online":{"date-parts":[[1994,1,1]]},"published-print":{"date-parts":[[1994,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.70.819.17","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,1]]},"published":{"date-parts":[[1994,1,1]]}}}