{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:26:48Z","timestamp":1781155608467,"version":"3.54.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"820","license":[{"start":{"date-parts":[[1994,2,1]],"date-time":"1994-02-01T00:00:00Z","timestamp":760060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Osteogenesis imperfecta (OI) is often regarded as a form of osteoporosis. However, the bone fragility is the result of defective collagen and earlier work has demonstrated that cortical thickness, in bones not previously fractured, is usually normal. We have now measured the bone mineral content of the distal forearm in 61 adult patients with well characterized OI.<\/jats:p>\n               <jats:p>Three patients with the Silence type III disorder had bone mass values well below the reference interval. For the 47 type I patients and 11 type IV patients, the bone mass was significantly lower than normal (P &amp;lt; 0.001). However 70% of patients had values within the reference interval. One cannot therefore exclude the diagnosis of OI by finding normal values with densitometry.<\/jats:p>\n               <jats:p>Diagnostic difficulties do not occur in type III patients and our main objective was to recruit as many individuals as possible with OI types I and IV. In the type IV disease, the diagnosis can be particularly difficult without a positive family history. Since the evaluation of bone density by subjective examination of radiographs is a much less precise procedure, most patients with type I and IV OI would be expected to have 'normal' appearances with this assessment. Osteogenesis imperfecta cannot be excluded on the basis of apparently normal bone density or cortical thickness with routine radiographs.<\/jats:p>","DOI":"10.1136\/pgmj.70.820.104","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"104-107","source":"Crossref","is-referenced-by-count":34,"title":["Bone density in osteogenesis imperfecta may well be normal"],"prefix":"10.1093","volume":"70","author":[{"given":"Colin R","family":"Paterson","sequence":"first","affiliation":[{"name":"Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School , Dundee DD1 9SY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A","family":"Mole","sequence":"additional","affiliation":[{"name":"Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School , Dundee DD1 9SY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,2,1]]},"reference":[{"key":"ref_1","first-page":"736","article-title":"Disorders of bone density, volume and mineralisation","volume-title":"Principles and Practice ofMedical Genetics","volume":"2","author":"Sillence, D.O.","year":"1983","unstructured":"Sillence, D.O. Disorders of bone density, volume and mineralisation. In: Emery, A.E.H., Rimoin, D.L. (eds) Principles and Practice ofMedical Genetics, Vol. 2. Churchill Livingstone, Edinburgh, 1983, pp. 736-751."},{"key":"ref_2","first-page":"48","article-title":"Generalised decrease in bone density. In: Orthopaedic Problems in Inherited Skeletal Disorders","author":"Horan, F.; Beighton, P.","year":"1982","unstructured":"Horan, F. & Beighton, P. Generalised decrease in bone density. In: Orthopaedic Problems in Inherited Skeletal Disorders. Springer-Verlag, Berlin, 1982, pp. 48-55."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/jmg.28.7.433","article-title":"Osteogenesis imperfecta: translation of mutation to phenotype","volume":"28","author":"Byers, P.H.; Wallis, G.A.; Willing, M.C.","year":"1991","unstructured":"Byers, P.H., Wallis, G.A. & Willing, M.C. Osteogenesis imperfecta: translation of mutation to phenotype. J Med Genet 1991, 28: 433-442.","journal-title":"J Med Genet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1651-2227.1987.tb10519.x","article-title":"Clinical and radiological features of osteogenesis imperfecta type IVA","volume":"76","author":"Paterson, C.R.; McAllion, S.J.; Shaw, J.W.","year":"1987","unstructured":"Paterson, C.R., McAllion, S.J. & Shaw, J.W. Clinical and radiological features of osteogenesis imperfecta type IVA. Acta Paediatr Scand 1987, 76: 548-552.","journal-title":"Acta Paediatr Scand"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/bmj.1.6107.213","article-title":"Metacarpal morphometry in adults with osteogenesis imperfecta","volume":"1","author":"Paterson, C.R.","year":"1978","unstructured":"Paterson, C.R. Metacarpal morphometry in adults with osteogenesis imperfecta. Br Med J 1978, 1: 213-214.","journal-title":"Br Med J"},{"issue":"37","key":"ref_6","first-page":"14","article-title":"Vertebral bone mineral content in osteogenesis imperfecta","volume":"1985","author":"Kurtz, D.; Morrish, K.; Shapiro, J.","unstructured":"Kurtz, D., Morrish, K. & Shapiro, J. Vertebral bone mineral content in osteogenesis imperfecta. Calcif Tissue Int 1985, 37: 14-18.","journal-title":"Calcif Tissue Int"},{"issue":"37","key":"ref_7","first-page":"1081","article-title":"Iliac bone histomorphometry in adults and children with osteogenesis imperfecta","volume":"1984","author":"Ste-Marie, L.G.; Charhon, S.A.; Edouard, C.; Chapuy, M.C.; Meunier, P.J.","unstructured":"Ste-Marie, L.G., Charhon, S.A., Edouard, C., Chapuy, M.C. & Meunier, P.J. Iliac bone histomorphometry in adults and children with osteogenesis imperfecta. J Clin Pathol 1984,37: 1081-1089.","journal-title":"J Clin Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence, D.O.; Senn, A.; Danks, D.M.","year":"1979","unstructured":"Sillence, D.O., Senn, A. & Danks, D.M. Genetic heterogeneity in osteogenesis imperfecta. J Med Genet 1979, 16: 101-116.","journal-title":"J Med Genet"},{"key":"ref_9","first-page":"508","article-title":"Osteogenesis imperfecta type I is commonly due to a COLlAl null allele of type I collagen","volume":"51","author":"Willing, M.C.; Pruchno, C.J.; Atkinson, M.; Byers, P.H.","year":"1992","unstructured":"Willing, M.C., Pruchno, C.J., Atkinson, M. & Byers, P.H. Osteogenesis imperfecta type I is commonly due to a COLlAl null allele of type I collagen. Am JHum Genet 1992, 51: 508-515.","journal-title":"Am JHum Genet"},{"key":"ref_10","first-page":"960","article-title":"Usefulness of regional bone measurements in patients with osteoporotic fractures of the spine and distal forearm","volume":"28","author":"Nilas, L.; Podenphant, J.; Riis, B.J.; Gotfredsen, A.; Christiansen, C.","year":"1987","unstructured":"Nilas, L., Podenphant, J., Riis, B.J., Gotfredsen, A. & Christiansen, C. Usefulness of regional bone measurements in patients with osteoporotic fractures of the spine and distal forearm. J Nucl Med 1987, 28: 960-965.","journal-title":"J Nucl Med"},{"issue":"74","key":"ref_11","first-page":"712","article-title":"Osteoporosis: the potentialities and limitations of its roentgenologic diagnosis","volume":"1955","author":"Lachman, E.","unstructured":"Lachman, E. Osteoporosis: the potentialities and limitations of its roentgenologic diagnosis. Am J Roentgenol 1955, 74: 712-715.","journal-title":"Am J Roentgenol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1259\/0007-1285-40-472-241","article-title":"An assessment of radiological criteria used in the study of spinal osteoporosis","volume":"40","author":"Doyle, F.H.; Gutteridge, D.H.; Joplin, G.F.; Fraser, R.","year":"1967","unstructured":"Doyle, F.H., Gutteridge, D.H., Joplin, G.F. & Fraser, R. An assessment of radiological criteria used in the study of spinal osteoporosis. Br J Radiol 1967, 40: 241-250.","journal-title":"Br J Radiol"},{"key":"ref_13","first-page":"27","article-title":"Osteoporosis: diagnosis by plain chest film versus dual photon absorptiometry","volume":"19","author":"Williamson, M.R.; Boyd, C.M.; Williamson, S.L.","year":"1990","unstructured":"Williamson, M.R., Boyd, C.M. & Williamson, S.L. Osteoporosis: diagnosis by plain chest film versus dual photon absorptiometry. 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