{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:35:04Z","timestamp":1768991704346,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"821","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 25 year old non-pregnant woman presented with a one-year history of amenorrhoea and polyuria. Three months before her admission, she had suffered lymphocytic meningitis. Hormonal studies revealed hypopituitarism and central diabetes insipidus, with associated primary autoimmune hypothyroidism. Computed tomographic scan and magnetic resonance imaging showed a pituitary mass with suprasellar extension and thickened stalk. Transsphenoidal surgery was performed and the histological study revealed fibrosis and diffuse lymphocytic infiltration with predominance of CD4 lymphocytes. This further case of lymphocytic hypophysitis was not related to pregnancy and produced diabetes insipidus, two uncommon associations. We discuss the features that can lead to a preoperative suspicion of this rare disorder.<\/jats:p>","DOI":"10.1136\/pgmj.70.821.220","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"220-224","source":"Crossref","is-referenced-by-count":41,"title":["Lymphocytic hypophysitis causing hypopituitarism and diabetes insipidus, and associated with autoimmune thyroiditis, in a non-pregnant woman"],"prefix":"10.1093","volume":"70","author":[{"given":"M","family":"Paja","sequence":"first","affiliation":[{"name":"Departments of Endocrinology, Clinica Puerta de Hierro , San Martin de Porres 4, 28035 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Estrada","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Clinica Puerta de Hierro , San Martin de Porres 4, 28035 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Clinica Puerta de Hierro , San Martin de Porres 4, 28035 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ram\u00f3n y Cajal","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Clinica Puerta de Hierro , San Martin de Porres 4, 28035 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Garc\u00eda-Ur\u00eda","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Clinica Puerta de Hierro , San Martin de Porres 4, 28035 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Lucas","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Clinica Puerta de Hierro , San Martin de Porres 4, 28035 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"issue":"83","key":"ref_1","first-page":"584","article-title":"Anterior hypophysitis and Hashimoto's disease in a young woman","volume":"1962","author":"Goudie, R.B.; Pinkerton, P.H.","unstructured":"Goudie, R.B. & Pinkerton, P.H. Anterior hypophysitis and Hashimoto's disease in a young woman. J Pathol Bacteriol 1962, 83: 584-585.","journal-title":"J Pathol Bacteriol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/jcem-64-3-631","article-title":"Lymphocytic hypophysitis in a man","volume":"64","author":"Guay, A.T.; Agnello, V.; Tronic, B.C.; Gresham, D.G.; Freidberg, S.R.","year":"1987","unstructured":"Guay, A.T., Agnello, V., Tronic, B.C., Gresham, D.G. & Freidberg, S.R. Lymphocytic hypophysitis in a man. J Clin Endocrinol Metab 1987, 64: 631-634.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_3","first-page":"457","article-title":"Lymphocytic hypophysitis. The clinical spectrum of the disorder and evidence for an autoimmune pathogenesis","volume":"33","author":"Pestell, R.G.; Best, J.D.; Alford, F.P.","year":"1990","unstructured":"Pestell, R.G., Best, J.D. & Alford, F.P. Lymphocytic hypophysitis. The clinical spectrum of the disorder and evidence for an autoimmune pathogenesis. Clin Endocrinol 1990, 33: 457-466.","journal-title":"Clin Endocrinol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1227\/00006123-199103000-00019","article-title":"Lymphocytic hypophysitis with involvement of the cavernous sinus and hypothalamus","volume":"28","author":"Nussbaum, C.E.; Okawara, S.H.; Jacobs, L.S.","year":"1991","unstructured":"Nussbaum, C.E., Okawara, S.H. & Jacobs, L.S. Lymphocytic hypophysitis with involvement of the cavernous sinus and hypothalamus. Neurosurgery 1991, 28: 440-444.","journal-title":"Neurosurgery"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0090-3019(89)90013-X","article-title":"Lymphocytic adenohypophysitis: report of two cases","volume":"32","author":"Miura, M.; Ushio, Y.; Kuratsu, J.I.; Ikeda, J.I.; Kai, Y.; Yamashiro, S.","year":"1989","unstructured":"Miura, M., Ushio, Y., Kuratsu, J.I., Ikeda, J.I., Kai, Y. & Yamashiro, S. Lymphocytic adenohypophysitis: report of two cases. Surg Neurol 1989, 32: 463-470.","journal-title":"Surg Neurol"},{"key":"ref_6","first-page":"211","article-title":"Lymphocytic hypophysitis in a patient with amenorrhea and hyperprolactinemia. A case report","volume":"31","author":"Wild, R.A.; Kepley, M.","year":"1986","unstructured":"Wild, R.A. & Kepley, M. Lymphocytic hypophysitis in a patient with amenorrhea and hyperprolactinemia. A case report. J Reprod Med 1986, 31: 211-216.","journal-title":"J Reprod Med"},{"key":"ref_7","first-page":"8221","article-title":"Lymphocytic adenohypophysitis presenting as infertility","volume":"74","author":"McCutcheon, I.E.; Oldfield, E.H.","year":"1991","unstructured":"McCutcheon, I.E. & Oldfield, E.H. Lymphocytic adenohypophysitis presenting as infertility. J Neurosurg 1991, 74: 8221-8226.","journal-title":"J Neurosurg"},{"issue":"15","key":"ref_8","first-page":"38","article-title":"Lymphocytic adenohypophysitis","volume":"1988","author":"McDermott, M.W.; Greisdale, D.E.; Berry, K.; Wilkins, G.E.","unstructured":"McDermott, M.W., Greisdale, D.E., Berry, K. & Wilkins, G.E. Lymphocytic adenohypophysitis. Can J Neurol Sci 1988, 15: 38-43.","journal-title":"Can J Neurol Sci"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0090-3019(87)90089-9","article-title":"Lymphocytic hypophysitis","volume":"28","author":"Vanneste, J.A.L.; Kamphorst, W.","year":"1987","unstructured":"Vanneste, J.A.L. & Kamphorst, W. Lymphocytic hypophysitis. Surg Neurol 1987, 28: 145-149.","journal-title":"Surg Neurol"},{"key":"ref_10","first-page":"35","article-title":"La selle turcique dans l'acromegalie. Etude radiologique","volume":"2","author":"Vezina, J.L.; Maltais, R.","year":"1973","unstructured":"Vezina, J.L. & Maltais, R. La selle turcique dans l'acromegalie. Etude radiologique. Neurochirugie 1973, 19 (Suppl 2): 35-56.","journal-title":"Neurochirugie"},{"key":"ref_11","first-page":"343","article-title":"Lymphocytic adenohypophysitis: autoimmune disorder of the pituitary gland","volume":"1","author":"Quencer, R.M.","year":"1980","unstructured":"Quencer, R.M. Lymphocytic adenohypophysitis: autoimmune disorder of the pituitary gland. AJNR 1980, 1: 343-345.","journal-title":"AJNR"},{"key":"ref_12","first-page":"619","article-title":"Lymphoid adenohypophysitis presenting as pituitary tumor","volume":"69","author":"Mayfield, R.K.; Levine, J.H.; Gordon, L.; Powers, J.; Galbraith, R.M.; Rawe, S.E.","year":"1980","unstructured":"Mayfield, R.K., Levine, J.H., Gordon, L., Powers, J., Galbraith, R.M. & Rawe, S.E. Lymphoid adenohypophysitis presenting as pituitary tumor. Am J Med 1980, 69: 619-623.","journal-title":"Am J Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00005792-198907000-00006","article-title":"Lymphocytic hypophysitis. Report of three new cases and review of the literature","volume":"68","author":"Cosman, F.; Post, K.D.; Holub, D.A.; Wardlaw, S.L.","year":"1989","unstructured":"Cosman, F., Post, K.D., Holub, D.A. & Wardlaw, S.L. Lymphocytic hypophysitis. Report of three new cases and review of the literature. Medicine 1989, 68: 240-256.","journal-title":"Medicine"},{"issue":"22","key":"ref_14","first-page":"937","article-title":"Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization","volume":"1988","author":"Levine, S.N.; Benzel, E.C.; Fowler, M.R.; Shroyer, J.V.; Mirfakhraee, M.","unstructured":"Levine, S.N., Benzel, E.C., Fowler, M.R., Shroyer, J.V. & Mirfakhraee, M. Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. Neurosurg 1988, 22: 937-941.","journal-title":"Neurosurg"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1210\/jcem.74.4.1548343","article-title":"Correlation between magnetic resonance imaging of posterior pituitary and neurohypophyseal function in children with diabetes insipidus","volume":"74","author":"Maghnie, M.; Villa, A.; Arico, M.","year":"1992","unstructured":"Maghnie, M., Villa, A., Arico, M. et al. Correlation between magnetic resonance imaging of posterior pituitary and neurohypophyseal function in children with diabetes insipidus. J Clin Endoc Metab 1992, 74: 795-800.","journal-title":"J Clin Endoc Metab"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1227\/00006123-198010000-00007","article-title":"Suprasellar germinomas (ectopic pinealomas): aspects of immunological characterization and successful chemotherapeutic responses in recurrent disease","volume":"7","author":"Neuwelt, E.A.; Frenkel, E.P.; Smith, R.G.","year":"1980","unstructured":"Neuwelt, E.A., Frenkel, E.P. & Smith, R.G. Suprasellar germinomas (ectopic pinealomas): aspects of immunological characterization and successful chemotherapeutic responses in recurrent disease. Neurosurgery 1980, 7: 352-358.","journal-title":"Neurosurgery"},{"key":"ref_17","first-page":"703","article-title":"Thickened pituitary stalk on MR images in patients with diabetes insipidus and Langerhans cell histiocytosis","volume":"11","author":"Tien, R.D.; Newton, T.H.; McDermott, M.W.; Dillon, W.P.; Kucharzyk, J.","year":"1990","unstructured":"Tien, R.D., Newton, T.H., McDermott, M.W., Dillon, W.P. & Kucharzyk, J. Thickened pituitary stalk on MR images in patients with diabetes insipidus and Langerhans cell histiocytosis. AJNR 1990, 11: 703-708.","journal-title":"AJNR"},{"issue":"95","key":"ref_18","first-page":"360","article-title":"Lymphocytic hypophysitis of pregnancy resulting in hypopituitarism: a distinct clinicopathologic entity","volume":"1981","author":"Asa, S.L.; Bilbao, J.M.; Kovacs, K.; Josse, R.G.; Kreines, K.","unstructured":"Asa, S.L., Bilbao, J.M., Kovacs, K., Josse, R.G. & Kreines, K. Lymphocytic hypophysitis of pregnancy resulting in hypopituitarism: a distinct clinicopathologic entity. Ann Intern Med 1981, 95: 360-363.","journal-title":"Ann Intern Med"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3171\/jns.1982.56.1.0148","article-title":"Lymphocytic adenohypophysitis of pregnancy simulating a pituitary adenoma: a distinct pathological entity. Report of two cases","volume":"56","author":"Baskin, D.S.; Townsend, J.J.; Wilson, C.B.","year":"1982","unstructured":"Baskin, D.S., Townsend, J.J. & Wilson, C.B. Lymphocytic adenohypophysitis of pregnancy simulating a pituitary adenoma: a distinct pathological entity. Report of two cases. J Neurosurg 1982, 56: 148-153.","journal-title":"J Neurosurg"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1471-0528.1981.tb01229.x","article-title":"Galactorrhea associated with lymphocytic adenohypophysitis. Case report","volume":"88","author":"Cebelin, M.S.; Velasco, M.E.; De Las Mulas, J.M.; Druet, R.L.","year":"1981","unstructured":"Cebelin, M.S., Velasco, M.E., De Las Mulas, J.M. & Druet, R.L. Galactorrhea associated with lymphocytic adenohypophysitis. Case report. Br J Obstet Gynecol 1981, 88: 675-680.","journal-title":"Br J Obstet Gynecol"},{"issue":"246","key":"ref_21","first-page":"1811","article-title":"Lymphoid hypophysitis. An unusual cause of hyperprolactinemia and enlarged sella turcica","volume":"1981","author":"Portocarrero, C.J.; Robinson, A.G.; Taylor, A.L.; Klein, I.","unstructured":"Portocarrero, C.J., Robinson, A.G., Taylor, A.L. & Klein, I. Lymphoid hypophysitis. An unusual cause of hyperprolactinemia and enlarged sella turcica. JAMA 1981, 246: 1811-1812.","journal-title":"JAMA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0002-9343(84)90710-1","article-title":"Primary hypothyroidism and hypopituitarism in a young woman","volume":"77","author":"McKeel, D.W.","year":"1984","unstructured":"McKeel, D.W. Primary hypothyroidism and hypopituitarism in a young woman. Am J Med 1984, 77: 319-330.","journal-title":"Am J Med"},{"key":"ref_23","first-page":"506","article-title":"Lymphocytic hypophysitis and pulmonary sarcoidosis. Report of a case","volume":"95","author":"Hayashi, H.; Yamada, K.; Kuroki, T.","year":"1991","unstructured":"Hayashi, H., Yamada, K., Kuroki, T. et al. Lymphocytic hypophysitis and pulmonary sarcoidosis. Report of a case. AJCP 1991, 95: 506-511.","journal-title":"AJCP"},{"issue":"35","key":"ref_24","first-page":"607","article-title":"A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis","volume":"1988","author":"Miyamoto, M.; Sugawa, H.; Mori, T.; Hashimoto, N.; Imura, H.","unstructured":"Miyamoto, M., Sugawa, H., Mori, T., Hashimoto, N. & Imura, H. A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. Endocrinol Jap 1988, 35: 607-616.","journal-title":"Endocrinol Jap"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0090-3019(91)90232-X","article-title":"Lymphocytic adenohypophysitis: an immunohistochemical study","volume":"36","author":"Hashimoto, M.; Yanaki, T.; Nakahara, N.; Masuzawa, T.","year":"1991","unstructured":"Hashimoto, M., Yanaki, T., Nakahara, N. & Masuzawa, T. Lymphocytic adenohypophysitis: an immunohistochemical study. Surg Neurol 1991, 36: 137-144.","journal-title":"Surg Neurol"},{"issue":"105","key":"ref_26","first-page":"200","article-title":"Lymphocytic hypophysitis with isolated corticotropin deficiency","volume":"1986","author":"Jensen, M.D.; Handwerger, B.S.; Bernd, W.S.; Carpenter, P.C.; Mirakian, R.; Banks, P.M.","unstructured":"Jensen, M.D., Handwerger, B.S., Bernd, W.S., Carpenter, P.C., Mirakian, R. & Banks, P.M. Lymphocytic hypophysitis with isolated corticotropin deficiency. Ann Intern Med 1986, 105: 200-203.","journal-title":"Ann Intern Med"},{"key":"ref_27","first-page":"2","article-title":"Hypophysitis and hypopituitarism: report of a case","volume":"1967","author":"Hume, R.; Roberts, G.H.","unstructured":"Hume, R. & Roberts, G.H. Hypophysitis and hypopituitarism: report of a case. Br Med J 1967, 2: 548-550.","journal-title":"Br Med J"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1001\/archinte.1980.00330200119034","article-title":"Lymphoid hypophysitis with selective adrenocorticotrophic hormone deficiency","volume":"140","author":"Richtsmeier, A.J.; Henry, R.A.; Blooworth, J.M.B.; Ehrlich, E.N.","year":"1980","unstructured":"Richtsmeier, A.J., Henry, R.A., Blooworth, J.M.B. & Ehrlich, E.N. Lymphoid hypophysitis with selective adrenocorticotrophic hormone deficiency. Arch Intern Med 1980, 140: 1243-1245.","journal-title":"Arch Intern Med"},{"issue":"41","key":"ref_29","first-page":"619","article-title":"Lymphoid hypophysitis associated with sudden maternal death: report ofa case and review ofthe literature","volume":"1986","author":"Gal, R.; Schwartz, A.; Gukowsky-Oren, S.; Peleg, D.; Goldman, J.; Kessler, E.","unstructured":"Gal, R., Schwartz, A., Gukowsky-Oren, S., Peleg, D., Goldman, J. & Kessler, E. Lymphoid hypophysitis associated with sudden maternal death: report ofa case and review ofthe literature. Obstet Gynecol Surv 1986, 41: 619-621.","journal-title":"Obstet Gynecol Surv"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1227\/00006123-198705000-00021","article-title":"Lymphocytic adenohypophysitis of pregnancy with complete recovery","volume":"20","author":"McGrail, K.M.; Beyerl, B.D.; Black, P.M.; Klibansky, A.; Zerbas, N.T.","year":"1987","unstructured":"McGrail, K.M., Beyerl, B.D., Black, P.M., Klibansky, A. & Zerbas, N.T. Lymphocytic adenohypophysitis of pregnancy with complete recovery. Neurosurgery 1987, 20: 791-793.","journal-title":"Neurosurgery"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0090-3019(91)90131-R","article-title":"The course of lymphocytic hypophysitis","volume":"36","author":"Bitton, R.N.; Slavin, M.; Decker, R.E.; Zito, J.; Schneider, B.S.","year":"1991","unstructured":"Bitton, R.N., Slavin, M., Decker, R.E., Zito, J. & Schneider, B.S. The course of lymphocytic hypophysitis. Surg Neurol 1991, 36: 40-43.","journal-title":"Surg Neurol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/821\/220\/50217601\/postgradmedj-70-220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/821\/220\/50217601\/postgradmedj-70-220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:03:10Z","timestamp":1684148590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/70\/821\/220\/7042345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3,1]]},"references-count":31,"journal-issue":{"issue":"821","published-online":{"date-parts":[[1994,3,1]]},"published-print":{"date-parts":[[1994,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.70.821.220","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,3]]},"published":{"date-parts":[[1994,3,1]]}}}