{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:38:22Z","timestamp":1770435502388,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"822","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>This report documents how respiratory sleep disorders can adversely effect ischaemic heart disease. Three male patients (aged 60-67 years) with proven ischaemic heart disease are described. They illustrate a spectrum of nocturnal cardiac dysfunction, two with nocturnal angina and one with nocturnal arrhythmias. Full sleep studies were performed in a dedicated sleep laboratory on all patients, and one patient had 48 hours of continuous Holter monitoring. Two patients were found to have obstructive sleep apnoea with apnoea\/hypopnoea indices of 57 and 36 per hour, respectively, the former with nocturnal arrhythmias and the latter with nocturnal angina. In both cases, nasal continuous positive airways pressure successfully treated the sleep apnoea, with an associated improvement in nocturnal arrhythmias and angina. The third patient who presented with nocturnal angina, did not demonstrate obstructive sleep apnoea (apnoea\/hypopnoea index = 7.2) but had significant oxygen desaturation during rapid eye movement (REM) sleep. This patient responded to a combination of nocturnal oxygen and protriptyline, an agent known to suppress REM sleep, and had no further nocturnal angina. All patients were considered to be an optimum cardiac medication and successful symptom resolution only occurred with the addition of specific therapy aimed at their sleep-related respiratory problem. We conclude that all patients with nocturnal angina or arrhythmias should have respiratory sleep abnormalities considered in their assessment.<\/jats:p>","DOI":"10.1136\/pgmj.70.822.275","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"275-280","source":"Crossref","is-referenced-by-count":16,"title":["Role of respiratory sleep disorders in the pathogenesis of nocturnal angina and arrhythmias"],"prefix":"10.1093","volume":"70","author":[{"given":"R","family":"Liston","sequence":"first","affiliation":[{"name":"Departments of Respiratory Medicine and Cardiology, and the Respiratory Sleep Laboratory, University College and St Vincent's Hospital , Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P C","family":"Deegan","sequence":"additional","affiliation":[{"name":"Departments of Respiratory Medicine and Cardiology, and the Respiratory Sleep Laboratory, University College and St Vincent's Hospital , Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"McCreery","sequence":"additional","affiliation":[{"name":"Departments of Respiratory Medicine and Cardiology, and the Respiratory Sleep Laboratory, University College and St Vincent's Hospital , Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W T","family":"McNicholas","sequence":"additional","affiliation":[{"name":"Departments of Respiratory Medicine and Cardiology, and the Respiratory Sleep Laboratory, University College and St Vincent's Hospital , Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJM199302043280502","article-title":"Sympathetic-nerve activity during sleep in normal subjects","volume":"328","author":"Somers, V.K.; Dyken, M.E.; Mark, A.L.; Abboud, F.M.","year":"1993","unstructured":"Somers, V.K., Dyken, M.E., Mark, A.L. & Abboud, F.M. 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National Institutes of Health, Washington, D.C., 1968 (publication no. 204).","journal-title":"National; C"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1152\/jappl.1967.22.3.407","article-title":"Measurement of the separate volume changes of ribcage and abdomen during breathing","volume":"22","author":"Konno, K.; Mead, J.","year":"1967","unstructured":"Konno, K. & Mead, J. Measurement of the separate volume changes of ribcage and abdomen during breathing. J Appl Physiol 1967, 22: 407-422.","journal-title":"J Appl Physiol"},{"key":"ref_8","first-page":"209","article-title":"Postural changes in ribcage and abdominal volume-motion coefficients and their effect on the calibration of a respiratory inductance plethysmograph","volume":"127","author":"Zimmerman, P.V.; Connellan, S.J.; Middleton, H.C.; Tabona, M.V.; Goldman, M.D.; Pride, N.","year":"1983","unstructured":"Zimmerman, P.V., Connellan, S.J., Middleton, H.C., Tabona, M.V., Goldman, M.D. & Pride, N. 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Am J Cardiol 1987, 59: 1305-1309.","journal-title":"Am J Cardiol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1378\/chest.82.5.548","article-title":"Disordered breathing and hypoxia during sleep in coronary artery disease","volume":"82","author":"De Olazabal, J.R.; Miller, M.J.; Cook, W.R.; Mithoefer, J.C.","year":"1982","unstructured":"De Olazabal, J.R., Miller, M.J., Cook, W.R. & Mithoefer, J.C. Disordered breathing and hypoxia during sleep in coronary artery disease. Chest 1982, 82: 548-552.","journal-title":"Chest"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJM197903083001001","article-title":"Sleep apnea, hypopnea and oxygen desaturation in normal subjects: a strong male predominance","volume":"300","author":"Block, A.J.; Boysen, P.G.; Wynne, J.W.; Hunt, L.A.","year":"1979","unstructured":"Block, A.J., Boysen, P.G., Wynne, J.W. & Hunt, L.A. 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Lancet 1979, i: 1-4.","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1056\/NEJM198210213071701","article-title":"Protriptyline in obstructive sleep apnea, a double blind trial","volume":"307","author":"Brownell, L.G.; West, P.; Sweatman, P.; Acres, J.C.; Kryger, M.H.","year":"1982","unstructured":"Brownell, L.G., West, P., Sweatman, P., Acres, J.C. & Kryger, M.H. Protriptyline in obstructive sleep apnea, a double blind trial. N EngI J Med 1982, 307: 1037-1042.","journal-title":"N EngI J Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/822\/275\/50217766\/postgradmedj-70-275.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/822\/275\/50217766\/postgradmedj-70-275.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:03:45Z","timestamp":1684148625000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/70\/822\/275\/7059329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,1]]},"references-count":21,"journal-issue":{"issue":"822","published-online":{"date-parts":[[1994,4,1]]},"published-print":{"date-parts":[[1994,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.70.822.275","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,4]]},"published":{"date-parts":[[1994,4,1]]}}}