{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:47:59Z","timestamp":1758815279280},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"822","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Of splenectomies performed in the Cork Regional Hospital over an 11 year period, ten were undertaken primarily for diagnostic purposes. A definitive histological diagnosis was established in nine patients, seven of whom had lymphoma, two with Hodgkin's disease and five with non-Hodgkin's lymphoma. The weight of the excised spleen in all patients with lymphoma exceeded 1 kg; in all those with a diagnosis other than lymphoma, the spleen weighed less than 1 kg. A majority of patients also had symptomatic improvement from reversal of hypersplenism and from relief of the mechanical pressure effects of an enlarged spleen. Operative mortality was zero.<\/jats:p>\n               <jats:p>Diagnostic splenectomy is a worthwhile procedure. Most patients will have lymphoma.<\/jats:p>","DOI":"10.1136\/pgmj.70.822.288","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"288-291","source":"Crossref","is-referenced-by-count":14,"title":["Splenectomy in patients with undiagnosed splenomegaly"],"prefix":"10.1093","volume":"70","author":[{"given":"C C","family":"Cronin","sequence":"first","affiliation":[{"name":"Departments of Medicine and Haematology, Regional Hospital , Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Surgery, Regional Hospital , Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Murphy","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Haematology, Regional Hospital , Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kenny","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Haematology, Regional Hospital , Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Whelton","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Haematology, Regional Hospital , Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hardiman","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Haematology, Regional Hospital , Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,4,1]]},"reference":[{"issue":"207","key":"ref_1","first-page":"581","article-title":"Splenectomy in haematologic disorders: the ever changing indications","volume":"1988","author":"Wilhelm, M.C.; Jones, R.E.; McGehee, R.; Mitchener, J.S.; Sanduscy, W.R.; Hess, C.E.","unstructured":"Wilhelm, M.C., Jones, R.E., McGehee, R., Mitchener, J.S., Sanduscy, W.R. & Hess, C.E. Splenectomy in haematologic disorders: the ever changing indications. Ann Surg 1988, 207: 581-589.","journal-title":"Ann Surg"},{"issue":"168","key":"ref_2","first-page":"896","article-title":"Splenectomy for the diagnosis of splenomegaly","volume":"1968","author":"Hermann, R.E.; DeHaven, K.E.; Hawk, W.A.","unstructured":"Hermann, R.E., DeHaven, K.E. & Hawk, W.A. Splenectomy for the diagnosis of splenomegaly. Ann Surg 1968, 168: 896-900.","journal-title":"Ann Surg"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/bjs.1800660120","article-title":"Splenectomy for undiagnosed splenomegaly","volume":"66","author":"Goonewardene, A.; Bourke, J.B.; Ferguson, R.; Toghill, P.J.","year":"1979","unstructured":"Goonewardene, A., Bourke, J.B., Ferguson, R. & Toghill, P.J. Splenectomy for undiagnosed splenomegaly. Br J Surg 1979, 66: 62-65.","journal-title":"Br J Surg"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bjs.1800740505","article-title":"Splenectomy for massive splenomegaly","volume":"74","author":"Bickerstaff, K.I.; Morris, P.J.","year":"1987","unstructured":"Bickerstaff, K.I. & Morris, P.J. Splenectomy for massive splenomegaly. Br J Surg 1987, 74: 346-349.","journal-title":"Br J Surg"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/archinte.1971.00310140087011","article-title":"Lymphosarcoma of the spleen","volume":"127","author":"Skarin, A.T.; Davey, F.R.; Moloney, W.C.","year":"1971","unstructured":"Skarin, A.T., Davey, F.R. & Moloney, W.C. Lymphosarcoma of the spleen. Arch Intern Med 1971, 127: 259-265.","journal-title":"Arch Intern Med"},{"issue":"17","key":"ref_6","first-page":"317","article-title":"'Non-tropical idiopathic splenomegaly' ('primary hypersplenism'): a review of ten cases and their relationship to malignant lymphoma","volume":"1969","author":"Dacie, J.V.; Brain, M.C.; Harrison, C.V.; Lewis, S.M.; Worlledge, S.M.","unstructured":"Dacie, J.V., Brain, M.C., Harrison, C.V., Lewis, S.M. & Worlledge, S.M. 'Non-tropical idiopathic splenomegaly' ('primary hypersplenism'): a review of ten cases and their relationship to malignant lymphoma. Br J Haematol 1969, 17: 317-333.","journal-title":"Br J Haematol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2141.1978.tb01035.x","article-title":"Non-tropical 'idiopathic splenomegaly': a followup study of ten patients described in 1969","volume":"38","author":"Dacie, J.V.; Galton, D.A.G.; Gordon-Smith, E.C.; Harrison, C.V.","year":"1978","unstructured":"Dacie, J.V., Galton, D.A.G., Gordon-Smith, E.C. & Harrison, C.V. Non-tropical 'idiopathic splenomegaly': a followup study of ten patients described in 1969. Br J Haematol 1978, 38: 185-193.","journal-title":"Br J Haematol"},{"key":"ref_8","first-page":"461","article-title":"Malignant lymphoma of the spleen: a review of 49 cases in which the diagnosis was made at splenectomy","volume-title":"Cancer","volume":"19","author":"Ahmann, D.L.; Kiely, J.M.; Harrison, E.G.","year":"1966","unstructured":"Ahmann, D.L., Kiely, J.M. & Harrison, E.G. Malignant lymphoma of the spleen: a review of 49 cases in which the diagnosis was made at splenectomy. Cancer 1966, 19: 461-469."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/1097-0142(19930101)71:1<207::AID-CNCR2820710132>3.0.CO;2-0","article-title":"Role of early splenectomy in malignant lymphomas with prominent splenic involvement (primary lymphomas of the spleen)","volume":"71","author":"Morel, P.; Dupriez, B.; Gosselin, B.","year":"1993","unstructured":"Morel, P., Dupriez, B., Gosselin, B. et al. Role of early splenectomy in malignant lymphomas with prominent splenic involvement (primary lymphomas of the spleen). Cancer 1993, 71: 207-215.","journal-title":"Cancer"},{"issue":"62","key":"ref_10","first-page":"1433","article-title":"Primary lymphoma of the spleen","volume":"1988","author":"Kehoe, J.; Straus, D.J.","unstructured":"Kehoe, J. & Straus, D.J. Primary lymphoma of the spleen. Cancer 1988, 62: 1433-1438.","journal-title":"Cancer"},{"key":"ref_11","first-page":"890","article-title":"Molecular biologic studies in the clinical evaluation of non-Hodgkin's lymphoma","volume":"5","author":"Hardy, R.; Horning, S.J.","year":"1991","unstructured":"Hardy, R. & Horning, S.J. Molecular biologic studies in the clinical evaluation of non-Hodgkin's lymphoma. Hematol Oncol Clin North Am 1991, 5: 890-891.","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0889-8588(18)30393-9","article-title":"New biologic markers in non-Hodgkin's lymphomas","volume":"5","author":"Grogan, T.M.; Miller, T.P.","year":"1991","unstructured":"Grogan, T.M. & Miller, T.P. New biologic markers in non-Hodgkin's lymphomas. Hematol Oncol Clin North Am 1991, 5: 925-933.","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref_13","first-page":"415","article-title":"Is splenectomy an outmoded procedure?","volume":"35","author":"Harrington, W.J.; Harrington, T.J.","year":"1990","unstructured":"Harrington, W.J. & Harrington, T.J. Is splenectomy an outmoded procedure? Adv Intern Med 1990, 35: 415-440.","journal-title":"Adv Intern Med"},{"issue":"145","key":"ref_14","first-page":"225","article-title":"Splenectomy: in and out of fashion","volume":"1985","author":"Crosby, W.H.","unstructured":"Crosby, W.H. Splenectomy: in and out of fashion. Arch Intern Med 1985, 145: 225-227.","journal-title":"Arch Intern Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/0140-6736(92)92555-T","article-title":"Is splenectomy another indication for Haemophilus influenzae type b vaccination?","volume":"340","author":"Teare, L.; O'Riordan, S.","year":"1992","unstructured":"Teare, L. & O'Riordan, S. Is splenectomy another indication for Haemophilus influenzae type b vaccination? Lancet 1992, 340: 1362 (letter).","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.2214\/ajr.139.6.1202","article-title":"Accelerated skeletal destruction after splenectomy in Gaucher type 1 disease","volume":"139","author":"Rose, J.S.; Grabowski, G.A.; Barnett, S.H.; Desnick, R.J.","year":"1982","unstructured":"Rose, J.S., Grabowski, G.A., Barnett, S.H. & Desnick, R.J. Accelerated skeletal destruction after splenectomy in Gaucher type 1 disease. Am J Roentgenol 1982, 139: 1202-1204.","journal-title":"Am J Roentgenol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00000658-196709000-00011","article-title":"Selective transsplenic decompression of gastroesophageal varices by distal splenorenal shunt","volume":"166","author":"Warren, W.D.; Zeppa, R.; Foman, J.J.","year":"1967","unstructured":"Warren, W.D., Zeppa, R. & Foman, J.J. Selective transsplenic decompression of gastroesophageal varices by distal splenorenal shunt. Ann Surg 1967, 166: 437-455.","journal-title":"Ann Surg"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0140-6736(87)90782-3","article-title":"Splenectomy in Hodgkin's disease and second leukaemias","volume":"ii:","author":"Van Leeuwen, F.E.; Sowers, R.; Hart, A.A.M.","year":"1987","unstructured":"Van Leeuwen, F.E., Sowers, R. & Hart, A.A.M. Splenectomy in Hodgkin's disease and second leukaemias. Lancet 1987, ii: 210-211.","journal-title":"Lancet"},{"key":"ref_19","first-page":"467","article-title":"Splenomegaly","volume-title":"Haematological Aspects of Systemic Disease. Bailiere Tindall","author":"Lin Yin, J.A.","year":"1990","unstructured":"Lin Yin, J.A. Splenomegaly. In: Delamore, I.W. & Lin Yin, J.A. (eds) Haematological Aspects of Systemic Disease. Bailiere Tindall, London, 1990, pp. 467-489."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/822\/288\/50217789\/postgradmedj-70-288.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/822\/288\/50217789\/postgradmedj-70-288.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:03:55Z","timestamp":1684148635000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/70\/822\/288\/7059327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,1]]},"references-count":19,"journal-issue":{"issue":"822","published-online":{"date-parts":[[1994,4,1]]},"published-print":{"date-parts":[[1994,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.70.822.288","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,4]]},"published":{"date-parts":[[1994,4,1]]}}}