{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:47:05Z","timestamp":1757702825898},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"827","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Fludarabine is one of the most recent and promising therapeutic agents for chronic lymphocytic leukaemia. We describe a patient who developed tumour lysis syndrome after the first course of treatment with fludarabine and call attention to this uncommon but potentially lethal complication that has not been previously taken into account in this neoplasia. It should always be anticipated when patients are treated with new and effective drugs.<\/jats:p>","DOI":"10.1136\/pgmj.70.827.651","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"651-652","source":"Crossref","is-referenced-by-count":9,"title":["Tumour lysis syndrome after treatment of chronic lymphocytic leukaemia with fludarabine"],"prefix":"10.1093","volume":"70","author":[{"given":"Carlos","family":"Montalban","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Lia\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abelardo","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 de Henares , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1001\/archinte.1987.00370020193063","article-title":"Acute tumor lysis syndrome in prolympyhocytic leukemia","volume":"147","author":"Gomez, G.A.; Han, T.","year":"1987","unstructured":"Gomez, G.A. & Han, T. Acute tumor lysis syndrome in prolympyhocytic leukemia. Arch Intern Med 1987, 147: 375-376.","journal-title":"Arch Intern Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/1097-0142(19900715)66:2<246::AID-CNCR2820660209>3.0.CO;2-B","article-title":"Acute tumor lysis syndrome and treatment response in patients treated for refractory chronic lymphoid leukemia with short course, high-dose cytosine arabinoside, cisplatin and etoposide","volume":"66","author":"McCroskey, R.D.; Mosher, D.F.; Spencer, C.D.; Prendergast, E.; Longo, W.L.","year":"1990","unstructured":"McCroskey, R.D., Mosher, D.F., Spencer, C.D., Prendergast, E. & Longo, W.L. Acute tumor lysis syndrome and treatment response in patients treated for refractory chronic lymphoid leukemia with short course, high-dose cytosine arabinoside, cisplatin and etoposide. Cancer 1990, 66: 246-250.","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1182\/blood.V74.1.19.bloodjournal74119","article-title":"Fludarabine: a new agent with major activity against chronic lymphocytic leukemia","volume":"74","author":"Keating, M.J.; Kantarjian, H.; Talpaz, M.","year":"1989","unstructured":"Keating, M.J., Kantarjian, H., Talpaz, M. et al. Fludarabine: a new agent with major activity against chronic lymphocytic leukemia. Blood 1989, 74: 19-25.","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1200\/JCO.1991.9.1.44","article-title":"Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia","volume":"9","author":"Keating, M.J.; Kantarjian, H.; O'Brien, S.","year":"1991","unstructured":"Keating, M.J., Kantarjian, H., O'Brien, S. et al. Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia. J Clin Oncol 1991, 9: 44-49.","journal-title":"J Clin Oncol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1200\/JCO.1992.10.5.790","article-title":"Phase II trial offludarabine phosphate in lymphoma: an effective new agent in low-grade lymphoma","volume":"10","author":"Redman, J.R.; Cabanillas, F.; Velasquez, W.S.","year":"1992","unstructured":"Redman, J.R., Cabanillas, F., Velasquez, W.S. et al. Phase II trial offludarabine phosphate in lymphoma: an effective new agent in low-grade lymphoma. J Clin Oncol 1992, 10: 790-794.","journal-title":"J Clin Oncol"},{"key":"ref_6","first-page":"737","article-title":"A review of its pharmacological properties and therapeutic potential in malignancy","volume":"45","author":"Ross, S.R.; McTavish, D.; Faulds, D.Fludarabine","year":"1993","unstructured":"Ross, S.R., McTavish, D. & Faulds, D. Fludarabine. A review of its pharmacological properties and therapeutic potential in malignancy. Drugs 1993, 45: 737-759.","journal-title":"Drugs"},{"key":"ref_7","first-page":"338","article-title":"Tumor lysis syndrome complicating treatment of chronic lymphocytic leukemia with fludarabine phosphate","volume":"89","author":"List, A.F.; Kummet, T.D.; Adams, J.D.; Chun, H.G.","year":"1990","unstructured":"List, A.F., Kummet, T.D., Adams, J.D. & Chun, H.G. Tumor lysis syndrome complicating treatment of chronic lymphocytic leukemia with fludarabine phosphate. Am J Med 1990, 89: 338-390.","journal-title":"Am J Med"},{"key":"ref_8","first-page":"371","article-title":"Immunosuppressive effects and clinical response of fludarabine in refractory chronic lymphocytic leukemia","volume":"4","author":"Bergmann, L.; Fenchel, K.; Jahn, B.; Mitrou, P.S.; Hoelzer, D.","year":"1993","unstructured":"Bergmann, L., Fenchel, K., Jahn, B., Mitrou, P.S. & Hoelzer, D. Immunosuppressive effects and clinical response of fludarabine in refractory chronic lymphocytic leukemia. Ann Oncol 1993, 4: 371-375."},{"key":"ref_9","first-page":"361","article-title":"A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: a Southwest oncology group study","volume-title":"Leukemia","volume":"7","author":"Elias, L.; Stock-Novack, D.; Head, D.R.","year":"1993","unstructured":"Elias, L., Stock-Novack, D., Head, D.R. et al. A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: a Southwest oncology group study. Leukemia 1993, 7: 361-365."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJM199211053271921","article-title":"Fludarabine and acute tumor lysis in chronic lymphocytic leukemia","volume":"327","author":"Frame, J.N.; Dahut, W.L.; Crowley, S.","year":"1992","unstructured":"Frame, J.N., Dahut, W.L. & Crowley, S. Fludarabine and acute tumor lysis in chronic lymphocytic leukemia. N Engi J Med 1992, 327: 1396-1397.","journal-title":"N Engi J Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/827\/651\/50217819\/postgradmedj-70-651.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/827\/651\/50217819\/postgradmedj-70-651.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:14:37Z","timestamp":1684149277000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/70\/827\/651\/7042307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9,1]]},"references-count":10,"journal-issue":{"issue":"827","published-online":{"date-parts":[[1994,9,1]]},"published-print":{"date-parts":[[1994,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.70.827.651","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,9]]},"published":{"date-parts":[[1994,9,1]]}}}