{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:28:40Z","timestamp":1697531320735},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"828","license":[{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 58 year old woman developed systemic symptoms, interstitial lung disease, splenomegaly, leukopenia and anti-histone and anti-nuclear antibodies (ANA), while treated with hydralazine for hypertension. Five months after presentation she was admitted with high fever, skin rash and atypical lymphocytosis due to acute cytomegalovirus (CMV) infection. Worsening leukopenia and increased ANA were found, and high titres of anti-DNA antibodies, anti-cardiolipin antibodies and rheumatoid factors appeared. Hydralazine was stopped and the patient gradually became asymptomatic. All autoantibodies spontaneously disappeared (over 16 weeks), and the white cell count and spleen size became normal. The patient was found to be a slow acetylator and to have both HLA-DR4 and selective IgA deficiency.<\/jats:p>\n               <jats:p>Thus, a multifactorial genetic susceptibility to develop drug-induced lupus was brought out in stages first by hydralazine and then by CMV, yet all manifestations and autoantibodies resolved spontaneously, demonstrating the complex interplay of varied environmental factors with a genetic predisposition in the pathogenesis of autoimmunity.<\/jats:p>","DOI":"10.1136\/pgmj.70.828.738","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"738-740","source":"Crossref","is-referenced-by-count":5,"title":["Effect of acute cytomegalovirus infection on drug-induced SLE"],"prefix":"10.1093","volume":"70","author":[{"given":"Ami","family":"Schattner","sequence":"first","affiliation":[{"name":"Departments of Medicine, Kaplan Hospital , Rehovot 76100, affiliated to the Hebrew University and Hadassah Medical School, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeev","family":"Sthoeger","sequence":"additional","affiliation":[{"name":"A and C, and R. Ben-Ari Institute of Clinical Immunology, Kaplan Hospital , Rehovot 76100, affiliated to the Hebrew University and Hadassah Medical School, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Geltner","sequence":"additional","affiliation":[{"name":"A and C, and R. Ben-Ari Institute of Clinical Immunology, Kaplan Hospital , Rehovot 76100, affiliated to the Hebrew University and Hadassah Medical School, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJM198410183111605","article-title":"Immunologic and genetic factors in autoimmune diseases","volume":"311","author":"Shoenfeld, Y.; Schwartz, R.S.","year":"1984","unstructured":"Shoenfeld, Y. & Schwartz, R.S. Immunologic and genetic factors in autoimmune diseases. N Engl J Med 1984, 311: 1019-1029.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/clinids\/12.2.204","article-title":"Virus-induced autoimmunity","volume":"12","author":"Schattner, A.; Rager-Zisman, B.","year":"1990","unstructured":"Schattner, A. & Rager-Zisman, B. Virus-induced autoimmunity. Rev Infect Dis 1990, 12: 204-222.","journal-title":"Rev Infect Dis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0002-9343(81)90250-3","article-title":"Drug-induced lupus: an adjuvant disease?","volume":"71","author":"Schoen, R.T.; Trentham, D.E.","year":"1981","unstructured":"Schoen, R.T. & Trentham, D.E. Drug-induced lupus: an adjuvant disease? Am J Med 1981, 71: 5-8.","journal-title":"Am J Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/bmj.284.6320.936","article-title":"Hydralazine antinuclear antibodies, and the lupus syndrome","volume":"284","author":"Mansilla-Tinoco, R.; Harland, S.J.; Ryan, P.J.","year":"1982","unstructured":"Mansilla-Tinoco, R., Harland, S.J., Ryan, P.J. et al. Hydralazine antinuclear antibodies, and the lupus syndrome. Br Med J 1982, 284: 936-939.","journal-title":"Br Med J"},{"issue":"289","key":"ref_5","first-page":"410","article-title":"The lupus syndrome induced by hydralazine: a common complication with low dose treatment","volume":"1984","author":"Cameron, H.A.; Ramsay, L.E.","unstructured":"Cameron, H.A. & Ramsay, L.E. The lupus syndrome induced by hydralazine: a common complication with low dose treatment. 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N Engl J Med 1988, 318: 1460-1462.","journal-title":"N Engl J Med"},{"key":"ref_10","first-page":"816","article-title":"Lymphocyte alteration by procainamide: relation to drug induced lupus erythematosus syndrome","volume":"2","author":"Bluestein, H.G.; Zvaifler, N.J.; Weisman, M.H.; Shapiro, R.F.","year":"1979","unstructured":"Bluestein, H.G., Zvaifler, N.J., Weisman, M.H. & Shapiro, R.F. Lymphocyte alteration by procainamide: relation to drug induced lupus erythematosus syndrome. Lancet 1979, 2: 816-819.","journal-title":"Lancet"},{"key":"ref_11","first-page":"881","article-title":"Laboratory diagnosis of drug-induced lupus","volume-title":"Systemic Lupus Erythematosus","author":"Weinstein, A.","year":"1987","unstructured":"Weinstein, A. Laboratory diagnosis of drug-induced lupus. In: Lahita, R.G. (ed.) Systemic Lupus Erythematosus. 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Immunology: aetiology of autoimmunity. Nature 1983, 304: 20.","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-2478(87)90094-0","article-title":"The origin of autoantibodies","volume":"14","author":"Schattner, A.","year":"1987","unstructured":"Schattner, A. The origin of autoantibodies. Immunol Lett 1987, 14: 143-153.","journal-title":"Immunol Lett"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/828\/738\/50218207\/postgradmedj-70-738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/828\/738\/50218207\/postgradmedj-70-738.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:25:12Z","timestamp":1684149912000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/70\/828\/738\/7059370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10,1]]},"references-count":17,"journal-issue":{"issue":"828","published-online":{"date-parts":[[1994,10,1]]},"published-print":{"date-parts":[[1994,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.70.828.738","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,10]]},"published":{"date-parts":[[1994,10,1]]}}}