{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:52:12Z","timestamp":1758127932636},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"829","license":[{"start":{"date-parts":[[1994,11,1]],"date-time":"1994-11-01T00:00:00Z","timestamp":783648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We validated a commercial enzyme-linked immunosorbent assay (ELISA), Helico-G, in diagnosing H. pylori in 129 patients (mean age 50 years, range 15-86). We analysed the results of endoscopy against serology to see whether there was a possibility of adopting the strategy of not endoscoping dyspeptic subjects under the age of 45. H. pylori infection was considered present if either histology and\/or culture were positive. The ELISA had a sensitivity of 88%, specificity of 72%, positive predictive value of 85%, negative predictive value of 77% and accuracy of 82% in detecting H. pylori. In a subgroup of 52 subjects aged 45 or less (mean age 35 years, range 15-45), 17 out of 25 patients with positive endoscopic findings were H. pylori seropositive while 16 out of 27 patients had normal endoscopic findings. Eighteen out of the 52 patients (35%) were H. pylori seronegative and normal endoscopically except for five patients (10%) who had mild to moderate oesophagitis and two who had non-erosive gastritis (4%). All patients with duodenal ulcer disease (7) were seropositive giving predictive values of positive and negative serology for a diagnosis of duodenal ulcer disease as 28% and 100%, respectively.<\/jats:p>\n               <jats:p>Therefore adopting a strategy of endoscoping subjects under the age of 45 only if they were H. pylori seropositive would have saved 35% of endoscopies in this age group but missed oesophagitis in 10%. Negative serology would tend to exclude duodenal ulcer disease while positive serology discriminates poorly for it. Serology may be a useful adjunct in screening to reduce endoscopy workload provided that patients with gastro-oesophageal reflux symptoms are excluded.<\/jats:p>","DOI":"10.1136\/pgmj.70.829.809","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"809-812","source":"Crossref","is-referenced-by-count":35,"title":["Possible role of Helicobacter pylori serology in reducing endoscopy workload"],"prefix":"10.1093","volume":"70","author":[{"given":"T C K","family":"Tham","sequence":"first","affiliation":[{"name":"Departments of Medicine, Atnagelvin Area Hospital , Londonderry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Atnagelvin Area Hospital , Londonderry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D F","family":"Hughes","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Atnagelvin Area Hospital , Londonderry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Atnagelvin Area Hospital , Londonderry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Crosbie","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Atnagelvin Area Hospital , Londonderry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Madden","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Atnagelvin Area Hospital , Londonderry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Namnyak","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Atnagelvin Area Hospital , Londonderry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F A","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Atnagelvin Area Hospital , Londonderry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"key":"ref_1","first-page":"64","article-title":"The serology of Helicobacter pylori infections","volume-title":"Helicobacter pylori and Gastroduodenal Disease","author":"Newell, D.G.; Stacey, A.R.","year":"1992","unstructured":"Newell, D.G. & Stacey, A.R. The serology of Helicobacter pylori infections. In: Rathbone, B.J. & Heatley, R.V. (eds). Helicobacter pylori and Gastroduodenal Disease, 2nd edn. Blackwell Scientific Publications, Oxford, 1992, pp. 64-73.","edition":"2nd edn"},{"key":"ref_2","first-page":"47","article-title":"Prevalence of symptoms ofdyspepsia in the community","volume":"1","author":"Jones, R.; Lydeard, S.","year":"1989","unstructured":"Jones, R. & Lydeard, S. Prevalence of symptoms ofdyspepsia in the community. Lancet 1989, 1: 47-51.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-642-75315-2_22","article-title":"Possible clinical uses of serology of Helicobacter pylori","volume-title":"Helicobacter pylori, Gastritis and Peptic Ulcer","author":"Sobala, G.M.","year":"1990","unstructured":"Sobala, G.M. Possible clinical uses of serology of Helicobacter pylori. In: Malfertheiner, P. & Ditschuneit, H. (eds) Helicobacter pylori, Gastritis and Peptic Ulcer. SpringerVerlag, Berlin, 1990, pp. 147-153."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1136\/bmj.280.6223.1136","article-title":"Endoscopic studies of dyspepsia in a general practice","volume":"280","author":"Gear, M.W.L.; Barnes, R.J.","year":"1980","unstructured":"Gear, M.W.L. & Barnes, R.J. Endoscopic studies of dyspepsia in a general practice. Br Med J 1980, 280&. 1136-1137.","journal-title":"Br Med J"},{"key":"ref_5","first-page":"2","article-title":"Do young patients with dyspepsia need investigation?","volume":"1988","author":"Williams, B.; Luckas, M.; Ellingham, J.H.M.; Dain, A.; Wicks, A.C.B.","unstructured":"Williams, B., Luckas, M., Ellingham, J.H.M., Dain, A. & Wicks, A.C.B. Do young patients with dyspepsia need investigation? Lancet 1988, 2: 1349-1351.","journal-title":"Lancet"},{"issue":"10","key":"ref_6","first-page":"75","article-title":"Comparison of serodiagnostic commercial kit for Helicobacter pylori detection using sera in Japan","volume":"161","author":"Yamamoto, I.; Fukuda, Y.; Tonokatsu, Y.","unstructured":"Yamamoto, I., Fukuda, Y., Tonokatsu, Y. et al. Comparison of serodiagnostic commercial kit for Helicobacter pylori detection using sera in Japan. Ir J Med Sci 1992, 161 (Suppl 10): 75.","journal-title":"Ir J Med Sci 1992"},{"issue":"10","key":"ref_7","first-page":"80","article-title":"Evaluation of ELISA in diagnosis of Helicobacterpylori infection","volume":"161","author":"Marks, J.; Gopal Rao, G.; Cobden, I.; Johri, R.; Johri, S.; Rodgers, A.D.","unstructured":"Marks, J., Gopal Rao, G., Cobden, I., Johri, R., Johri, S. & Rodgers, A.D. Evaluation of ELISA in diagnosis of Helicobacterpylori infection. Ir J Med Sci 1992, 161 (Suppl 10): 80.","journal-title":"Ir J Med Sci 1992"},{"issue":"10","key":"ref_8","first-page":"81","article-title":"Serological diagnosis of Helicobacter pylorievaluation of four tests in the presence or absence of non-steroidal anti-inflammatory drugs","volume":"161","author":"Tahar, A.S.; Reid, J.; Boothmann, P.","unstructured":"Tahar, A.S., Reid, J., Boothmann, P. et al. Serological diagnosis of Helicobacter pylorievaluation of four tests in the presence or absence of non-steroidal anti-inflammatory drugs. Ir J Med Sci 1992, 161 (Suppl 10): 81.","journal-title":"Ir J Med Sci 1992"},{"issue":"24","key":"ref_9","article-title":"pylori serology reduces the workload from direct access endoscopy","volume":"82","author":"Mendall, M.A.; Goggin, P.M.; Molineaux, N.J.","year":"1992","unstructured":"Mendall, M.A., Goggin, P.M., Molineaux, N.J. et al. H. pylori serology reduces the workload from direct access endoscopy. Clin Sci 1992, 82 (Suppl): 24P.","journal-title":"Clin Sci"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1136\/gut.31.11.1237","article-title":"Evaluation of 13C-urea breath test in the detection of Helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia","volume":"31","author":"Dill, S.; Payne-James, J.J.; Misiewicz, J.J.","year":"1990","unstructured":"Dill, S., Payne-James, J.J., Misiewicz, J.J. et al. Evaluation of 13C-urea breath test in the detection of Helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia. Gut 1990, 31: 1237-1241.","journal-title":"Gut"},{"key":"ref_11","first-page":"12","article-title":"Peptic ulcer","volume-title":"Oxford Textbook of Medicine","author":"Misiewicz, J.J.; Pounder, R.E.","year":"1987","unstructured":"Misiewicz, J.J. & Pounder, R.E. Peptic ulcer. In: Weatherall, D.J., Ledingham, J.G.G. & Warrell, D.A. (eds) Oxford Textbook of Medicine, 2nd edn. Oxford University Press, Oxford, 1987, pp. 12.64-12.77.","edition":"2nd edn"},{"key":"ref_12","first-page":"991","article-title":"Screening for Helicobacter pylori antibody could reduce endoscopy workload in young dyspeptic patients","volume":"4","author":"Collins, J.S.A.; Bamford, K.B.; Sloan, J.M.; Collins, B.J.; Moorehead, R.J.; Love, A.H.G.","year":"1992","unstructured":"Collins, J.S.A., Bamford, K.B., Sloan, J.M., Collins, B.J., Moorehead, R.J. & Love, A.H.G. Screening for Helicobacter pylori antibody could reduce endoscopy workload in young dyspeptic patients. Eur J Gastroenterol Hepatol 1992, 4: 991-993.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0140-6736(90)90287-F","article-title":"Symptoms in gastro-oesophageal reflux disease","volume":"335","author":"Klauser, A.G.; Schindlbeck, N.E.; Muller-Lissner, S.A.","year":"1990","unstructured":"Klauser, A.G., Schindlbeck, N.E. & Muller-Lissner, S.A. Symptoms in gastro-oesophageal reflux disease. Lancet 1990, 335: 205-208.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3109\/00365528609011128","article-title":"Oesophagitis, signs of reflux, and gastric secretion in patients with symptoms of gastro-oesophageal reflux disease","volume":"21","author":"Johansson, K.E.; Ask, P.; Boeryd, B.; Fransson, S.-G.; Tibbling, L.","year":"1986","unstructured":"Johansson, K.E., Ask, P., Boeryd, B., Fransson, S.-G. & Tibbling, L. Oesophagitis, signs of reflux, and gastric secretion in patients with symptoms of gastro-oesophageal reflux disease. Scand J Gastroenterol 1986, 21: 837-847.","journal-title":"Scand J Gastroenterol"},{"key":"ref_15","first-page":"72","article-title":"The symptoms of gastro-oesophageal reflux and oesophagitis","volume":"106","year":"1984","unstructured":"Knill-Jones, R.P;, Card, W.I., Crean, G.P., James, W.B. & Spiegelhalter, D.J. The symptoms of gastro-oesophageal reflux and oesophagitis. Scand J Gastroenterol 1984, 19 (Suppl 106): 72-76.","journal-title":"Scand J Gastroenterol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1001\/archinte.1989.00390060097020","article-title":"Prevalence of Campylobacter pylori in oesophagitis, gastritis and duodenal disease","volume":"149","author":"Cheng, E.H.; Bermanski, P.; Silversmith, M.; Valenstein, P.; Kawanishi, H.","year":"1989","unstructured":"Cheng, E.H., Bermanski, P., Silversmith, M., Valenstein, P. & Kawanishi, H. Prevalence of Campylobacter pylori in oesophagitis, gastritis and duodenal disease. 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