{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:55:33Z","timestamp":1760608533523},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"830","license":[{"start":{"date-parts":[[1994,12,1]],"date-time":"1994-12-01T00:00:00Z","timestamp":786240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Patients with acquired von Willebrand disease may present with severe bleeding, which is usually difficult to manage. Adequate haemostasis in acquired von Willebrand disease may be achieved with the infusion of factor VIII\/von Willebrand factor concentrates or with the administration of desmopressin. We report a case of acquired von Willebrand disease with severe postoperative bleeding, responding poorly to classical von Willebrand factor replacement therapy but successfully treated with high-dose intravenous gammaglobulins. This new treatment mode of acquired von Willebrand disease is discussed in the light of a critical analysis of the literature.<\/jats:p>","DOI":"10.1136\/pgmj.70.830.916","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"916-920","source":"Crossref","is-referenced-by-count":20,"title":["High-dose intravenous gammaglobulin therapy for acquired von Willebrand disease"],"prefix":"10.1093","volume":"70","author":[{"given":"Perry J J","family":"Van Genderen","sequence":"first","affiliation":[{"name":"Departments of Haematology, University Hospital Dijkzigt, Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri N M","family":"Papatsonis","sequence":"additional","affiliation":[{"name":"Departments of Gynaecology and Obstetrics, University Hospital Dijkzigt , Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan J","family":"Michiels","sequence":"additional","affiliation":[{"name":"Departments of Haematology, University Hospital Dijkzigt, Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenne J","family":"Wielenga","sequence":"additional","affiliation":[{"name":"Departments of Haematology, University Hospital Dijkzigt, Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Stibbe","sequence":"additional","affiliation":[{"name":"Departments of Haematology, University Hospital Dijkzigt, Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans J M","family":"Huikeshoven","sequence":"additional","affiliation":[{"name":"Departments of Gynaecology and Obstetrics, University Hospital Dijkzigt , Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1055\/s-0038-1648506","article-title":"The structure and function of von Willebrand factor","volume":"67","author":"Ruggeri, Z.; Ware, J.","year":"1992","unstructured":"Ruggeri, Z. & Ware, J. The structure and function of von Willebrand factor. Thromb Haemostas 1992, 67: 594-599.","journal-title":"Thromb Haemostas"},{"issue":"64","key":"ref_2","first-page":"614","article-title":"Studies of the pathophysiology of acquired von Willebrand's disease in seven patients with lymphoproliferative disorders or benign monoclonal gammopathies","volume":"1984","author":"Mannucci, P.M.; Lombardi, R.; Bader, R.","unstructured":"Mannucci, P.M., Lombardi, R., Bader, R. et al. Studies of the pathophysiology of acquired von Willebrand's disease in seven patients with lymphoproliferative disorders or benign monoclonal gammopathies. Blood 1984, 64: 614-621.","journal-title":"Blood"},{"key":"ref_3","first-page":"221","article-title":"Clinical manifestations and pathophysiology of acquired von Willebrand's disease in association with benign monoclonal gammapathy, multiple myeloma and lymphoproliferative disorders","volume-title":"Monoclonal Gammapathies III - Clinical Significance and Basis Mechanism","author":"Van Genderen, P.J.J.; Michiels, J.J.","year":"1991","unstructured":"Van Genderen, P.J.J. & Michiels, J.J. Clinical manifestations and pathophysiology of acquired von Willebrand's disease in association with benign monoclonal gammapathy, multiple myeloma and lymphoproliferative disorders. In: Radl, J. & van Camp, B. (eds) Monoclonal Gammapathies III - Clinical Significance and Basis Mechanism. EURAGE, Leiden, 1991, pp. 221-225."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2141.1992.tb04562.x","article-title":"Acquired type II von Willebrand's disease with adrenal cortical carcinoma","volume":"80","author":"Facon, T.; Caron, C.; Courtin, P.","year":"1992","unstructured":"Facon, T., Caron, C., Courtin, P. et al. Acquired type II von Willebrand's disease with adrenal cortical carcinoma. Br J Haematol 1992, 80: 488-494.","journal-title":"Br J Haematol"},{"issue":"52","key":"ref_5","first-page":"90","article-title":"Acquired von Willebrand's syndrome associated with hydatid disease of the spleen: disappearance after splenectomy","volume":"1984","author":"Richard, C.; Sedano, M.C.; Cuadrado, M.A.; Recio, M.; Hermosa, V.; Zubizarreta, A.","unstructured":"Richard, C., Sedano, M.C., Cuadrado, M.A., Recio, M., Hermosa, V. & Zubizarreta, A. Acquired von Willebrand's syndrome associated with hydatid disease of the spleen: disappearance after splenectomy. Thromb Haemostas 1984, 52: 90-93.","journal-title":"Thromb Haemostas"},{"key":"ref_6","first-page":"1007","article-title":"Hypothyroidism as a cause of acquired von Willebrand's disease","volume":"i:","author":"Dalton, R.G.; Savidge, G.F.; Matthews, K.B.","year":"1987","unstructured":"Dalton, R.G., Savidge, G.F., Matthews, K.B. et al. Hypothyroidism as a cause of acquired von Willebrand's disease. Lancet 1987, i: 1007-1009.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-2007-994004","article-title":"Therapy of von Willebrand disease","volume":"19","author":"Scott, J.P.; Montgomery, R.R.","year":"1993","unstructured":"Scott, J.P. & Montgomery, R.R. Therapy of von Willebrand disease. Semin Thromb Hemastas 1993, 19: 37-47.","journal-title":"Semin Thromb Hemastas"},{"issue":"70","key":"ref_8","first-page":"387","article-title":"High-dose intravenous gammaglobulin for acquired von Willebrand's disease","volume":"1988","author":"Delannoy, A.; Saillez, A.C.","unstructured":"Delannoy, A. & Saillez, A.C. High-dose intravenous gammaglobulin for acquired von Willebrand's disease. Br J Haematol 1988, 70: 387-389.","journal-title":"Br J Haematol"},{"issue":"112","key":"ref_9","first-page":"143","article-title":"The use of high-dose intravenous gammaglobulin in acquired von Willebrand's syndrome","volume":"1988","author":"Macik, B.G.; Gabriel, D.A.; White, G.C.; High, K.; Roberts, H.","unstructured":"Macik, B.G., Gabriel, D.A., White, G.C., High, K. & Roberts, H. The use of high-dose intravenous gammaglobulin in acquired von Willebrand's syndrome. Arch Pathol Lab Med 1988, 112: 143-146.","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"ref_10","first-page":"391","article-title":"Severe acquired von Willebrand's disease responds to immunoglobulin infusion (abstract)","volume":"74","author":"Hillyer, C.D.; Sajer, S.A.; Furie, B.; Berkman, E.M.","year":"1989","unstructured":"Hillyer, C.D., Sajer, S.A., Furie, B. & Berkman, E.M. Severe acquired von Willebrand's disease responds to immunoglobulin infusion (abstract). Blood 1989, 74 (Suppl 1): 391.","journal-title":"Blood"},{"issue":"74","key":"ref_11","first-page":"387","article-title":"Acquired von Willebrand's disease and angiodysplasia: response to intravenous immune globulin (abstract)","volume":"1989","author":"Ballard, J.O.; Sanders, J.C.; Eyster, M.E.","unstructured":"Ballard, J.O., Sanders, J.C. & Eyster, M.E. Acquired von Willebrand's disease and angiodysplasia: response to intravenous immune globulin (abstract). Blood 1989,74 (Suppl 1): 387.","journal-title":"Blood"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1365-2141.1992.tb04610.x","article-title":"Efficacy ofhigh-dose intravenous gammaglobulin in the management of acquired von Willebrand's disease during orthopaedic surgery","volume":"82","author":"Gross, S.; Traulle, C.; Capiod, J.C.","year":"1992","unstructured":"Gross, S., Traulle, C., Capiod, J.C. et al. Efficacy ofhigh-dose intravenous gammaglobulin in the management of acquired von Willebrand's disease during orthopaedic surgery. Br J Haematol 1992, 82: 170-171.","journal-title":"Br J Haematol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ajh.2830410212","article-title":"Effectiveness of high dose intravenous immunoglobulin in a case of acquired von Willebrand's syndrome with chronic melena not responsive to desmopressin and factor VIII concentrate","volume":"41","author":"Castaman, G.; Tosetto, A.; Rodeghiero, F.","year":"1992","unstructured":"Castaman, G., Tosetto, A. & Rodeghiero, F. Effectiveness of high dose intravenous immunoglobulin in a case of acquired von Willebrand's syndrome with chronic melena not responsive to desmopressin and factor VIII concentrate. Am J Hematol 1992, 41: 132-136.","journal-title":"Am J Hematol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/ajh.2830400214","article-title":"Acquired von Willebrand disease: correction of hemostatic defect by high-dose intravenous immunoglobulins","volume":"40","author":"Delmer, A.; Horellou, M.H.; Brechot, J.M.","year":"1992","unstructured":"Delmer, A., Horellou, M.H., Brechot, J.M. et al. Acquired von Willebrand disease: correction of hemostatic defect by high-dose intravenous immunoglobulins. Am J Hematol 1992, 40: 151-152.","journal-title":"Am J Hematol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2141.1993.tb03074.x","article-title":"Gastro-intestinal bleeding in acquired von Willebrand's disease: efficacy of high-dose immunoglobulin where substitution treatments failed","volume":"84","author":"White, L.A.; Chisholm, M.","year":"1993","unstructured":"White, L.A. & Chisholm, M. Gastro-intestinal bleeding in acquired von Willebrand's disease: efficacy of high-dose immunoglobulin where substitution treatments failed. Br J Haematol 1993, 84: 332-334.","journal-title":"Br J Haematol"},{"key":"ref_16","article-title":"Effectiveness of high-dose intravenous gammaglobulin therapy in acquired von Willebrand's disease","author":"Van Genderen, P.J.J.; Michiels, J.J.; Bakker, J.J.; van't Veer, M.B.","year":"1994","unstructured":"Van Genderen, P.J.J., Michiels, J.J., Bakker, J.J. & van't Veer, M.B. Effectiveness of high-dose intravenous gammaglobulin therapy in acquired von Willebrand's disease. Vox Sanguinis 1994 (in press).","journal-title":"Vox Sanguinis"},{"key":"ref_17","first-page":"2","article-title":"Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin","volume":"1984","author":"Sultan, Y.; Kazatchkine, M.D.; Maisonneuve, P.; Nydegger, U.E.","unstructured":"Sultan, Y., Kazatchkine, M.D., Maisonneuve, P. & Nydegger, U.E. Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin. Lancet 1984, 2: 765-768.","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1046\/j.1537-2995.1987.27387235627.x","article-title":"The efficacy of intensive plasma exchange in acquired von Willebrand's disease","volume":"27","author":"Silberstein, L.E.; Abrahm, J.; Shattil, S.J.","year":"1987","unstructured":"Silberstein, L.E., Abrahm, J. & Shattil, S.J. The efficacy of intensive plasma exchange in acquired von Willebrand's disease. Transfusion 1987, 27: 234-237.","journal-title":"Transfusion"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJM198901263200418","article-title":"Successful treatment of an acquired von Willebrand factor antibody by extracorporeal immunoadsorption","volume":"320","author":"Uehlinger, J.; Rose, E.; Aledort, L.M.; Lemer, R.","year":"1989","unstructured":"Uehlinger, J., Rose, E., Aledort, L.M. & Lemer, R. Successful treatment of an acquired von Willebrand factor antibody by extracorporeal immunoadsorption. N Engl J Med 1989, 320: 254-255.","journal-title":"N Engl J Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/830\/916\/50218307\/postgradmedj-70-916.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/70\/830\/916\/50218307\/postgradmedj-70-916.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:56:04Z","timestamp":1684151764000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/70\/830\/916\/7059421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12,1]]},"references-count":19,"journal-issue":{"issue":"830","published-online":{"date-parts":[[1994,12,1]]},"published-print":{"date-parts":[[1994,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.70.830.916","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,12]]},"published":{"date-parts":[[1994,12,1]]}}}