{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:16:20Z","timestamp":1761488180131},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"830","license":[{"start":{"date-parts":[[1994,12,1]],"date-time":"1994-12-01T00:00:00Z","timestamp":786240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 43 year old woman in remission from acute myeloid leukaemia developed abdominal pain, severe melaena, diarrhoea and gram-negative septicaemia whilst severely pancytopenic following consolidation chemotherapy. Subsequently, serial abdominal X-rays showed a progressive toxic megacolon. Conservative management was attempted but, because of radiological evidence of increasing colonic dilatation and incipient perforation, an emergency defunctioning colostomy was performed. The patient recovered and 2 months later the caecostomy was reversed and a right hemicolectomy performed.<\/jats:p>\n               <jats:p>This first described case of toxic megacolon following leukaemia treatment is compared with three previously described cases following cytotoxic chemotherapy for other conditions.<\/jats:p>","DOI":"10.1136\/pgmj.70.830.921","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"921-923","source":"Crossref","is-referenced-by-count":5,"title":["Toxic megacolon complicating chemotherapy for acute myeloid leukaemia"],"prefix":"10.1093","volume":"70","author":[{"given":"M A","family":"Wodzi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Haematology, Northern General Hospital , Sheffield S5 7AU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Snowden","sequence":"additional","affiliation":[{"name":"Department of Haematology, Northern General Hospital , Sheffield S5 7AU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J T","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Haematology, Northern General Hospital , Sheffield S5 7AU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1136\/bmj.304.6838.1367","article-title":"Non-specific inflammatory bowel disease","volume":"304","author":"Pettit, S.; Irving, M.H.","year":"1992","unstructured":"Pettit, S. & Irving, M.H. 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