{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:56:59Z","timestamp":1759341419974},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"831","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A retrospective study of infants with bacterial meningitis admitted to our hospital during 1949-52, highlighted the lack of \u2018classical\u2019 signs of meningitis in these infants. We carried out a similar review of 44 infants aged less than three months, admitted during 1982-91. We also determined the causative organisms and their antibiotic sensitivities. Symptoms and signs were similar in the two series. Forty infants in the later series were either febrile, irritable or had seizures on the day of admission. Overall mortality fell from 30% to 11%. Between 1982 and 1991 Group B Streptocococcus and Neisseria meningitidis were the commonest causes of meningitis. All organisms, except one, were sensitive to ampicillin and\/or cefotaxime. Bacterial meningitis should be suspected in young infants who are febrile, irritable or having seizures. Initial treatment with ampicillin and cefotaxime is appropriate.<\/jats:p>","DOI":"10.1136\/pgmj.71.831.36","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"36-38","source":"Crossref","is-referenced-by-count":8,"title":["Bacterial meningitis in the first three months of life"],"prefix":"10.1093","volume":"71","author":[{"given":"F A I","family":"Riordan","sequence":"first","affiliation":[{"name":"University of Liverpool , Liverpool , UK"},{"name":"Institute of Child Health"},{"name":"Department of Medical Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P J","family":"Thomson","sequence":"additional","affiliation":[{"name":"University of Liverpool , Liverpool , UK"},{"name":"Institute of Child Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Sills","sequence":"additional","affiliation":[{"name":"University of Liverpool , Liverpool , UK"},{"name":"Institute of Child Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(53)92058-3","article-title":"The diagnosis of acute meningitis in infancy","volume":"i:","author":"Haworth, J.C.","year":"1953","unstructured":"Haworth JC. The diagnosis of acute meningitis in infancy. Lancet 1953; i: 911-4.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/bmj.2.5970.533","article-title":"Emergence of group B streptococci in obstetric and perinatal infections","volume":"2","author":"Reid, T.M.S.","year":"1975","unstructured":"Reid TMS. Emergence of group B streptococci in obstetric and perinatal infections. BMJ 1975; 2: 533-6.","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1136\/adc.66.5.603","article-title":"Infantile meningitis in England and Wales: a two year study","volume":"66","author":"de Louvois J; J, Blackbourn; R, Hurley; D, Harvey","year":"1991","unstructured":"de Louvois J, Blackbourn J, Hurley R, Harvey D. Infantile meningitis in England and Wales: a two year study. 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Arch Dis Child 1990; 65:1-2.","journal-title":"Arch Dis Child"},{"key":"ref_6","first-page":"1052","article-title":"Bacterial meningitis in older neonates","volume":"137","author":"Baumgartner, E.T.; Augustine, A.; Steele, R.W.","year":"1983","unstructured":"Baumgartner ET, Augustine A, Steele RW. Bacterial meningitis in older neonates. Am J Dis Child 1983; 137: 1052-4.","journal-title":"Am J Dis Child"},{"key":"ref_7","first-page":"1005","article-title":"Initial antibiotic treatment of purulent meningitis in infants 1 to 2 months of age","volume":"137","author":"Enzenauer, R.W.; Bass, J.W.","year":"1983","unstructured":"Enzenauer RW, Bass JW. Initial antibiotic treatment of purulent meningitis in infants 1 to 2 months of age. Am J Dis Child 1983; 137: 1005-6.","journal-title":"Am J Dis Child"},{"key":"ref_8","first-page":"47","article-title":"Chloramphenicol levels in children with meningococcal disease","volume":"7","year":"1993","unstructured":"Marzouk 0, Nunn AJ, Thomson APJ, Sills JA, Hart CA. Chloramphenicol levels in children with meningococcal disease. Pediatric Rev Commun 1993; 7, 47-53.","journal-title":"Pediatric Rev Commun"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/00006454-199209000-00005","article-title":"Therapy of bacterial sepsis, meningitis and otitis media in infants and children: 1992 poll of directors of programs in pediatric infectious diseases","volume":"11","author":"Klass, P.E.; Klein, J.O.","year":"1992","unstructured":"Klass PE, Klein JO. Therapy of bacterial sepsis, meningitis and otitis media in infants and children: 1992 poll of directors of programs in pediatric infectious diseases. Pediatr Infect DisJ 1992; 11: 702-5.","journal-title":"Pediatr Infect DisJ"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/00006454-199209000-00039","article-title":"Diagnosis and managements of meningitis","volume":"11","author":"Feigin, R.D.; GH, Jr, McCraken; Klein, J.O.","year":"1992","unstructured":"Feigin RD, McCraken GH Jr, Klein JO. Diagnosis and managements of meningitis. Pediatr Infect Dis J 1992; 11, 785-814.","journal-title":"Pediatr Infect Dis J"},{"key":"ref_11","first-page":"273","article-title":"Infection of the nervous system in the newborn","volume-title":"Arneil's Textbook of Paediatrics","author":"Rennie, J.M.","year":"1992","unstructured":"Rennie JM. Infection of the nervous system in the newborn. In: Campbell AGM, McIntosh N, eds. Forfar and Arneil's Textbook of Paediatrics. Edinburgh: Churchill Livingstone, 1992; p 273."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/831\/36\/50219078\/postgradmedj-71-36.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/831\/36\/50219078\/postgradmedj-71-36.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T22:24:54Z","timestamp":1683757494000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/71\/831\/36\/7044141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1,1]]},"references-count":11,"journal-issue":{"issue":"831","published-online":{"date-parts":[[1995,1,1]]},"published-print":{"date-parts":[[1995,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.71.831.36","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,1]]},"published":{"date-parts":[[1995,1,1]]}}}