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Later deaths are related more closely to the consequences of multiple organ dysfunction. Monoclonal antibodies and other immunotherapies have been developed against bacterial products, cytokines and other mediators involved in this systemic inflammatory response. Immunotherapies may improve outcome in the critically ill with sepsis if used early and as part of the therapeutic regimen of antimicrobial agents and intensive care support.<\/jats:p>","DOI":"10.1136\/pgmj.71.832.71","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"71-78","source":"Crossref","is-referenced-by-count":6,"title":["Immunotherapy in the management of sepsis"],"prefix":"10.1093","volume":"71","author":[{"given":"E A","family":"Fagan","sequence":"first","affiliation":[{"name":"Division of Hepatology, Joint Department of Medicine, University College of London Medical School and Royal Free Hospital School of Medicine , London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Singer","sequence":"additional","affiliation":[{"name":"Bloomsbury Institute of Intensive Care Medicine, University College of London Medical School , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jama.1993.03510100083038","article-title":"The clinical evaluation of new drugs for sepsis. 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Treatment of gram-negative septic shock with an immunoglobulin preparation. Intensive Care Med 1994; 20 (suppl 1): S591 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_37","first-page":"592","article-title":"Immunotherapy of sepsis with Sandoglobulin","volume":"1","author":"Dominioni, L.; Gennari, R.; Dionigi, R.","year":"1994","unstructured":"Dominioni L, Gennari R, Dionigi R. Immunotherapy of sepsis with Sandoglobulin. Intensive Care Med 1994; 20 (suppl 1): S592 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_38","first-page":"593","article-title":"Polyglobin NR","volume":"1","author":"K, Werdan; the SBITS Study Group","year":"1994","unstructured":"Werdan K and the SBITS Study Group. Polyglobin NR. 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J Infect Dis 1985; 151: 1012-8.","journal-title":"J Infect Dis"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0732-8893(93)90109-K","article-title":"Effect of antibiotics on endotoxin release from Gram-negative bacteria","volume":"16","author":"Eng, R.H.K.; Smith, S.M.; Fan-Havard, P.; Ogbara, T.","year":"1993","unstructured":"Eng RHK, Smith SM, Fan-Havard P, Ogbara T. Effect of antibiotics on endotoxin release from Gram-negative bacteria. Diagn Microbiol Infect Dis 1993; 16: 185-9.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/330662a0","article-title":"Anticachectin\/TNF monoclonal antibodies prevent septic shock during lethal bacteremia","volume":"330","author":"Tracey, K.J.; Fong, Y.; Hesse, D.G.","year":"1987","unstructured":"Tracey KJ, Fong Y, Hesse DG, et al. Anticachectin\/TNF monoclonal antibodies prevent septic shock during lethal bacteremia. 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Recombinant human interleukin-l receptor antagonist (rhIL-Ira) increases survival time in patients with sepsis-induced organ dysfunction. Intensive Care Med 1994; 20 (suppl 1): S598 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_55","first-page":"600","article-title":"the rhIL-Ira Phase III Sepsis Study Group. The relationship between patient risk and efficacy of immunotherapy of sepsis","volume":"1","author":"and, Knaus WA","year":"1994","unstructured":"Knaus WA and the rhIL-Ira Phase III Sepsis Study Group. The relationship between patient risk and efficacy of immunotherapy of sepsis. Intensive Care Med 1994; 20 (suppl 1): S600 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_56","first-page":"209","article-title":"Anti-inflammatory properties of IL-10","volume":"1","author":"de Vries JE","year":"1994","unstructured":"de Vries JE. Anti-inflammatory properties of IL-10. Intensive Care Med 1994; 20 (suppl 1): S209 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/362248a0","article-title":"Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses","volume":"362","author":"Minty, A.; Chalon, P.; Derocq, J.M.","year":"1993","unstructured":"Minty A, Chalon P, Derocq, JM, et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 1993; 362: 248-50.","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.4049\/jimmunol.150.12.5436","article-title":"Structural comparison and chromosomal localization of the human and mouse IL-13 genes","volume":"150","author":"McKenzie, A.N.; Largaespada, D.A.; Sato, A.","year":"1993","unstructured":"McKenzie AN, Largaespada DA, Sato A, et al. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol 1993; 150: 5436-44.","journal-title":"J Immunol"},{"key":"ref_59","first-page":"587","article-title":"The metabolic effects of platelet-activating factor antagonism in lethal primate bacteremia and human endotoxemia","volume":"1","author":"Thompson, W.; Moldawer, L.L.; Lowry, S.F.","year":"1994","unstructured":"Thompson W, Moldawer LL, Lowry SF. The metabolic effects of platelet-activating factor antagonism in lethal primate bacteremia and human endotoxemia. Intensive Care Med 1994; 20 (suppl 1): S587 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_60","first-page":"600","article-title":"Guinot Ph and the Sepsis Study Group. PAF antagonist (BN 52021) in severe Gram-negative sepsis","volume":"1","author":"Dhainaut, J.F.; Tenaillon, A.","year":"1994","unstructured":"Dhainaut JF, Tenaillon A, Guinot Ph and the Sepsis Study Group. PAF antagonist (BN 52021) in severe Gram-negative sepsis. Intensive Care Med 1994; 20 (suppl 1): S600 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_61","first-page":"1","article-title":"The role of the contact system in systemic inflammatory response syndrome","volume":"1","author":"Colman, R.W.","year":"1994","unstructured":"Colman RW. The role of the contact system in systemic inflammatory response syndrome. Intensive Care Med 1994; 20 (suppl 1): S1 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_62","first-page":"6","article-title":"Inhibition of factor XII in septic baboons attenuates activation of complement and fibrinolytic systems and reduces the release of neutrophil elastase","volume":"1","author":"Jansen, P.M.; Pixley, R.A.; Chang, A.C.K.","year":"1994","unstructured":"Jansen PM, Pixley RA, Chang ACK, et al. Inhibition of factor XII in septic baboons attenuates activation of complement and fibrinolytic systems and reduces the release of neutrophil elastase. Intensive Care Med 1994; 20 (suppl 1): S6 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_63","first-page":"7","article-title":"Cl-inhibitor substitution therapy in the vascular leak syndrome induced by high doses of interleukin-2","volume":"1","author":"Hack, C.E.; Ogilvie, A.C.; Wagstaff, J.; Thijs, L.G.","year":"1994","unstructured":"Hack CE, Ogilvie AC, Wagstaff J, Thijs LG. Cl-inhibitor substitution therapy in the vascular leak syndrome induced by high doses of interleukin-2. Intensive Care Med 1994; 20 (suppl 1): S7 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/00003246-199206000-00028","article-title":"Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis","volume":"20","author":"Bone, R.C.","year":"1992","unstructured":"Bone RC. Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis. Crit Care Med 1992; 20: 884-90.","journal-title":"Crit Care Med"},{"key":"ref_65","first-page":"104","article-title":"Anti-adhesion molecule strategies as a therapeutic modality: an overview","volume":"1","author":"Doerschuk, C.M.","year":"1994","unstructured":"Doerschuk CM. Anti-adhesion molecule strategies as a therapeutic modality: an overview. Intensive Care Med 1994; 20 (suppl 1): S104 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_66","first-page":"106","article-title":"Modulation of neutrophilendothelial cell adhesion with anti-CD11\/ CD128 monoclonal antibodies as a therapeutic modality","volume":"1","author":"Wortel, C.H.","year":"1994","unstructured":"Wortel CH. Modulation of neutrophilendothelial cell adhesion with anti-CD11\/ CD128 monoclonal antibodies as a therapeutic modality. Intensive Care Med 1994; 20 (suppl 1): S106 (abstract).","journal-title":"Intensive Care Med"},{"key":"ref_67","first-page":"107","article-title":"Anti-ICAM-l monoclonal antibody in hepatic ischemic injury","volume":"1","author":"Menger, M.D.; Vollmar, B.","year":"1994","unstructured":"Menger MD, Vollmar B. Anti-ICAM-l monoclonal antibody in hepatic ischemic injury. Intensive Care Med 1994; 20 (suppl 1): S107 (abstract).","journal-title":"Intensive Care Med"},{"issue":"3","key":"ref_68","first-page":"413","article-title":"CP-0127, a novel potent bradykinin antagonist, increases survival in rat and rabbit models of endotoxin shock","volume":"38","author":"Whalley, E.T.; Solomon, J.A.; Modafferi, D.M.; Bonham, K.A.; Cheronis, J.C.","year":"1992","unstructured":"Whalley ET, Solomon JA, Modafferi DM, Bonham KA, Cheronis JC. CP-0127, a novel potent bradykinin antagonist, increases survival in rat and rabbit models of endotoxin shock. Agents Actions Suppl 1992; 38 (Pt 3): 413-20.","journal-title":"Agents Actions Suppl"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1093\/infdis\/162.6.1349","article-title":"Tumor necrosis factor-alpha plays a role in host defense against Histoplasma capsulatum","volume":"162","author":"Smith, J.G.; Magee, D.M.; Williams, D.M.; Graybill, JR","year":"1990","unstructured":"Smith JG, Magee DM, Williams DM, Graybill JR. Tumor necrosis factor-alpha plays a role in host defense against Histoplasma capsulatum. J Infect Dis 1990; 162: 1349-53.","journal-title":"J Infect Dis"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1097\/00003246-199309000-00003","article-title":"Nitric oxide as a target for therapy in septic shock","volume":"21","author":"Cobb, J.P.; Cunnion, R.E.; Danner, R.L.","year":"1993","unstructured":"Cobb JP, Cunnion RE, Danner RL. Nitric oxide as a target for therapy in septic shock. Crit Care Med 1993; 21: 1261-3.","journal-title":"Crit Care Med"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/infdis\/162.2.421","article-title":"Prophylactic and therapeutic effects of a monoclonal antibody to tumor necrosis factor-alpha in experimental Gram negative shock","volume":"162","author":"Silva, A.T.; Bayston, K.F.; Cohen, J.","year":"1990","unstructured":"Silva AT, Bayston KF, Cohen J. Prophylactic and therapeutic effects of a monoclonal antibody to tumor necrosis factor-alpha in experimental Gram negative shock. J Infect Dis 1990; 162: 421-7.","journal-title":"J Infect Dis"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/infdis\/162.2.454","article-title":"Monoclonal antibody to endotoxin core protects mice from Escherichia coli sepsis by a mechanism independent oftumor necrosis factor and interleukin-6","volume":"162","author":"Silva, A.T.; Appelmelk, B.J.; Buurman, W.A.; Bayston, K.F.; Cohen, J.","year":"1990","unstructured":"Silva AT, Appelmelk BJ, Buurman WA, Bayston KF, Cohen J. Monoclonal antibody to endotoxin core protects mice from Escherichia coli sepsis by a mechanism independent oftumor necrosis factor and interleukin-6. J Infect Dis 1990; 162: 454-9.","journal-title":"J Infect Dis"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/infdis\/164.4.800","article-title":"Differences in release of tumor necrosis factor from THP-1 cells stimulated by filtrates of antibiotic-killed Escherichia coli","volume":"164","author":"Simon, D.M.; Koenig, G.; Trenholme, G.M.","year":"1991","unstructured":"Simon DM, Koenig G, Trenholme GM. Differences in release of tumor necrosis factor from THP-1 cells stimulated by filtrates of antibiotic-killed Escherichia coli. J Infect Dis 1991; 164: 800-2.","journal-title":"J Infect Dis"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/infdis\/167.1.240","article-title":"Antibioticinduced bacterial killing stimulates tumor necrosis factor-alpha release in whole blood","volume":"167","author":"Arditi, M.; Kabat, W.; Yogev, R.","year":"1993","unstructured":"Arditi M, Kabat W, Yogev R. 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