{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:29:15Z","timestamp":1770982155103,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"832","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a prospective study designed to assess the effect of Helicobacter pylori eradication on peptic ulcer healing, 85 consecutive patients with H. pylori-positive peptic ulcer disease were treated with a triple therapy regimen consisting of colloidal bismuth subcitrate 120 mg four times daily for 28 days, with metronidazole 400 mg three times daily and tetracycline 500 mg three times daily for the first seven days of treatment. H. pylori status was assessed by CLO test and histology at least four weeks after completing therapy. Of 75 patients (88%) H. pylori-negative after therapy, 69 (92%) had healed ulcers compared with only five of 10 patients (50%) who remained H. pylori-positive (p = 0.003). Cigarette smoking had no significant effect on ulcer healing. Our results suggest that H. pylori eradication may accelerate ulcer healing and provide further evidence that an effective helicobactericidal regimen is the treatment of choice in H. pylori-positive peptic ulcer.<\/jats:p>","DOI":"10.1136\/pgmj.71.832.90","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"90-93","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Helicobacter pylori eradication on peptic ulcer healing"],"prefix":"10.1093","volume":"71","author":[{"given":"H J","family":"O\u2019Connor","sequence":"first","affiliation":[{"name":"General Hospital, Tullamore, Co Offaly, Eire Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Kanduru","sequence":"additional","affiliation":[{"name":"General Hospital, Tullamore, Co Offaly, Eire Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Bhutta","sequence":"additional","affiliation":[{"name":"General Hospital, Tullamore, Co Offaly, Eire Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Meehan","sequence":"additional","affiliation":[{"name":"General Hospital, Tullamore, Co Offaly, Eire Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"Feeley","sequence":"additional","affiliation":[{"name":"General Hospital, Tullamore, Co Offaly, Eire Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Cunnane","sequence":"additional","affiliation":[{"name":"Department of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,2,1]]},"reference":[{"key":"ref_1","first-page":"1109","article-title":"Campylobacter pylori and recurrence of duodenal ulcers - a 12-month follow-up study","volume":"2","author":"Coghlan, J.G.; Gilligan, D.; Humphries, H.","year":"1987","unstructured":"Coghlan JG, Gilligan D, Humphries H, et al. Campylobacter pylori and recurrence of duodenal ulcers - a 12-month follow-up study. Lancet 1987; 2: 1109-11.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(90)91301-P","article-title":"Cure of duodenal ulcer associated with eradication of Helicobacter pylori","volume":"335","author":"Rauws, E.A.J.; Tytgat, G.N.J.","year":"1990","unstructured":"Rauws EAJ, Tytgat GNJ. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 1990; 335: 1233-5.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5694\/j.1326-5377.1990.tb136833.x","article-title":"Cure of duodenal ulcer after eradication of Helicobacter pylori","volume":"153","author":"George, L.L.; Borody, T.J.; Andrews, P.","year":"1990","unstructured":"George LL, Borody TJ, Andrews P, et al. Cure of duodenal ulcer after eradication of Helicobacter pylori. 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Gastroenterol Clin N Am 1993; 22: 105-15.","journal-title":"Gastroenterol Clin N Am"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0140-6736(88)90929-4","article-title":"Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori","volume":"2","author":"Marshall Bj, Goodwin CS, Warren JR","year":"1988","unstructured":"Marshall Bj, Goodwin CS, Warren JR, et al. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet 1988; 2: 1437-42.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.7326\/0003-4819-115-4-266","article-title":"Effect of triple therapy (antibiotics plus bismuth) on duodenal ulcer healing with ranitidine","volume":"115","author":"Graham, D.Y.; Lew, G.M.; Evans, D.G.; DJ, Jr, Evans; Klein, P.D.","year":"1991","unstructured":"Graham DY, Lew GM, Evans DG, Evans DJ Jr, Klein PD. 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Eradication of Helicobacter pylori: therapies and clinical implications. 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