{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:24Z","timestamp":1761058884305},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"833","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the UK, approximately 5000 patients present annually with acute lower limb ischaemia. The aetiology is usually thromboembolic disease, other causes include aortic dissection and arterial trauma. Over the past two decades thrombosis has replaced embolism as the principal cause of acute ischaemia, and now accounts for approximately 59% of cases. As a consequence, intra-arterial thrombolysis is being increasingly used as first-line treatment for this condition.<\/jats:p>","DOI":"10.1136\/pgmj.71.833.146","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"146-150","source":"Crossref","is-referenced-by-count":5,"title":["Lower limb intra-arterial thrombolysis"],"prefix":"10.1093","volume":"71","author":[{"given":"J","family":"Golledge","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Royal Berkshire Hospital, Reading , Berkshire , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"Galland","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Royal Berkshire Hospital, Reading , Berkshire , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"ref_1","first-page":"19","article-title":"Management of the acutely ischaemic limb","volume-title":"Clinical problems in vascular surgery","author":"Giddings, A.E.B.; QuraishyY, M.S.","year":"1994","unstructured":"Giddings AEB, QuraishyY MS. Management of the acutely ischaemic limb. In: Galland RB, Clyne CAC, eds. Clinical problems in vascular surgery. London: Edward Arnold, 1994, pp 19-29."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1084\/jem.58.4.485","article-title":"The fibrinolytic activity of haemolytic streptococci","volume":"58","author":"Tillet, W.S.; Garner, R.L.","year":"1993","unstructured":"Tillet WS, Garner RL. The fibrinolytic activity of haemolytic streptococci. J Exp Med 1993; 58: 485-502.","journal-title":"J Exp Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI103941","article-title":"Lysis of intravascular clots in man by intravenous streptokinase","volume":"38","author":"Johnson, A.J.; McCarty, W.R.","year":"1959","unstructured":"Johnson AJ, McCarty WR. Lysis of intravascular clots in man by intravenous streptokinase. 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