{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:22:21Z","timestamp":1770502941421,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"834","license":[{"start":{"date-parts":[[1995,4,1]],"date-time":"1995-04-01T00:00:00Z","timestamp":796694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The clinical features and risk of hepatotoxicity of \u2018Sleep-Qik\u2019 (valerian dry extract 75 mg, hyoscine hydrobromide 0.25 mg, cyproheptadine hydrochloride 2 mg) were determined in 23 patients treated in our hospital between 1988 and 1991. The main clinical problems were central nervous system depression and anticholinergic poisoning. There was no clinical evidence of acute hepatitis in the 23 patients after taking an average of 2.5 g of valerian (range 0.5 to 12 g). There was no evidence of subclinical liver damage in 12 patients who had routine liver function tests performed approximately 6-12 hours after ingestion. Delayed onset of severe liver damage was excluded in 10 patients in whom a telephone follow-up was possible. However, subclinical liver dysfunction in the acute stage (onset after 12-24 hours) and in the intervening period after discharge from hospital could not be excluded. To establish the risk of hepatotoxicity in long-term users and in those taking an overdosage of valerian, a much larger study of longer duration with serial liver function tests is clearly needed.<\/jats:p>","DOI":"10.1136\/pgmj.71.834.227","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"227-228","source":"Crossref","is-referenced-by-count":28,"title":["Poisoning due to an over-the-counter hypnotic, Sleep-Qik (hyoscine, cyproheptadine, valerian)"],"prefix":"10.1093","volume":"71","author":[{"given":"T Y K","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, The Chinese University of Hong Kong, Prince of Wales Hospital , Shatin NT , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, The Chinese University of Hong Kong, Prince of Wales Hospital , Shatin NT , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A J H","family":"Critchley","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, The Chinese University of Hong Kong, Prince of Wales Hospital , Shatin NT , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2165\/00002018-199207030-00008","article-title":"Adverse reactions to drugs as a cause of admissions to a general teaching hospital in Hong Kong","volume":"7","author":"Chan, T.Y.K.; Chan, J.C.N.; Tomlinson, B.; Critchley, J.A.J.H.","year":"1992","unstructured":"Chan TYK, Chan JCN, Tomlinson B, Critchley JAJH. Adverse reactions to drugs as a cause of admissions to a general teaching hospital in Hong Kong. Drug Safety 1992; 7: 235-40.","journal-title":"Drug Safety"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1177\/096032719401300711","article-title":"Drug overdosage and other poisoning in Hong Kong - the Prince of Wales Hospital (Shatin) experience","volume":"13","author":"Chan, T.Y.K.; Critchley, J.A.J.H.; Chan, M.T.V.; Yu, C.M.","year":"1994","unstructured":"Chan TYK, Critchley JAJH, Chan MTV, Yu CM. Drug overdosage and other poisoning in Hong Kong - the Prince of Wales Hospital (Shatin) experience. 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The biological activity of valerian and related plants. J Ethnopharmacol 1988; 22: 121-42.","journal-title":"J Ethnopharmacol"},{"key":"ref_6","first-page":"80","article-title":"Herbal remedies used in sedative and antirheumatic preparations: part 1","volume":"233","author":"Phillipson, J.D.; Anderson, L.A.","year":"1984","unstructured":"Phillipson JD, Anderson LA. Herbal remedies used in sedative and antirheumatic preparations: part 1. Pharm J 1984; 233: 80-2.","journal-title":"Pharm J"},{"key":"ref_7","first-page":"241","article-title":"Activitee comparee de preparations galeniques de Valeriane, Valeriana officinalis, sur les comportement de la souris","volume":"39","author":"Bounthanh, D.; Missain, R.; Anton, R.","year":"1980","unstructured":"Bounthanh D, Missain R, Anton R. Activitee comparee de preparations galeniques de Valeriane, Valeriana officinalis, sur les comportement de la souris. Plant Med 1980; 39: 241-2.","journal-title":"Plant Med"},{"key":"ref_8","first-page":"1109","article-title":"Valepotriate mit Epoxidstruktur - beatliche Alkylantien","volume":"122","author":"Braun, R.; Dittmar, W.; Machut, M.; Weickmann, S.","year":"1982","unstructured":"Braun R, Dittmar W, Machut M, Weickmann S. Valepotriate mit Epoxidstruktur - beatliche Alkylantien. Dtsche Apothek Z 1982; 122: 1109-13.","journal-title":"Dtsche Apothek Z"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/bmj.282.6259.186","article-title":"Mistletoe hepatitis","volume":"282","author":"Harvey, J.; Collin-Jones, D.G.","year":"1981","unstructured":"Harvey J, Collin-Jones DG. Mistletoe hepatitis. BMJt 1981; 282: 186-7.","journal-title":"BMJt"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/pgmj.68.805.935","article-title":"Hepatic and pulmonary complications of herbal medicines","volume":"68","author":"Miskelly, F.G.; Goodyer, L.I.","year":"1992","unstructured":"Miskelly FG, Goodyer LI. Hepatic and pulmonary complications of herbal medicines. Postgrad Med J 1992; 68: 935.","journal-title":"Postgrad Med J"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/834\/227\/50218763\/postgradmedj-71-227.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/834\/227\/50218763\/postgradmedj-71-227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T23:04:31Z","timestamp":1683759871000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/71\/834\/227\/7044176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4,1]]},"references-count":10,"journal-issue":{"issue":"834","published-online":{"date-parts":[[1995,4,1]]},"published-print":{"date-parts":[[1995,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.71.834.227","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,4]]},"published":{"date-parts":[[1995,4,1]]}}}