{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:23:30Z","timestamp":1773059010588,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"837","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A policy of Helicobacter pylori eradication in patients with duodenal ulceration on long-term acid-suppressing therapy was evaluated in a prospective study amongst a general practice population, with particular reference to economic and quality-of-life benefits. One hundred and sixty-eight patients on long-term acid-suppressing therapy had chronic duodenal ulcer disease of whom 88 were eligible for the study; 45 patients attended for review, with 42 testing positive for H pylori (as assessed by 13C-urea breath test). The median duration of acid-suppressing therapy was six years (maximum 15 years); 47.6% of the patients were using additional antacids and 80.9% still experienced epigastric discomfort. Two-thirds (28\/42) of the patients eradicated H pylori. Successful eradication was associated with a highly significant reduction in all symptoms. At 12 months follow-up, heartburn had decreased from 28.7% to 7.1%, epigastric discomfort from 75% to 3.6%, nausea from 32.1% to 0% and wind from 50% to 0%. Of the patients that eradicated H pylori 96.4% reported an improvement in their general health compared to none of those that remained H pylori positive. Successful H pylori eradication therapy scored higher on satisfaction ratings than long-term acid-suppressing therapy. Eradication of H pylori resulted in 27\/28 patients being able to discontinue acid-suppressing therapy, representing a 5.8% reduction in the use of such drugs per year in the local general practice population. A policy of H pylori eradication in chronic duodenal ulcer disease reduces the use of long-term acid-suppression therapy in general practice. This has important financial implications as well as offering considerable symptomatic benefits to the patients and improving their quality of life.<\/jats:p>","DOI":"10.1136\/pgmj.71.837.413","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"413-418","source":"Crossref","is-referenced-by-count":20,"title":["The economic and quality-of-life benefits of Helicobacter pylori eradication in chronic duodenal ulcer disease--a community-based study"],"prefix":"10.1093","volume":"71","author":[{"given":"P S","family":"Phull","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Northwick Park Hospital , Harrow, Middlesex HA1 3UJ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D","family":"Ryder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northwick Park Hospital , Harrow, Middlesex HA1 3UJ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Halliday","sequence":"additional","affiliation":[{"name":"Department of Nutrition Research, Northwick Park Hospital , Harrow, Middlesex HA1 3UJ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A B","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Northwick Park Hospital , Harrow, Middlesex HA1 3UJ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northwick Park Hospital , Harrow, Middlesex HA1 3UJ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Jacyna","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northwick Park Hospital , Harrow, Middlesex HA1 3UJ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"issue":"2","key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2036.1993.tb00594.x","article-title":"The need for longterm treatment of peptic ulcer","volume":"7","author":"Dobrilla, G.; Zancanella, L.; Amplatz, S.","year":"1993","unstructured":"Dobrilla G, Zancanella L, Amplatz S. The need for longterm treatment of peptic ulcer. Aliment Pharmacol Ther 1993; 7 (suppl 2): 3-15.","journal-title":"Aliment Pharmacol Ther"},{"issue":"23","key":"ref_2","first-page":"23","article-title":"Ulcer treatment: regimens and duration of inhibition of acid secretion - how long to dose","volume":"1988","author":"Bauerfind, P.; Hoelz, H.R.; Blum, A.L.","unstructured":"Bauerfind P, Hoelz HR, Blum AL. Ulcer treatment: regimens and duration of inhibition of acid secretion - how long to dose. Scand J Gastroenterol 1988: 23 (suppl 153): 23-34.","journal-title":"Scand J Gastroenterol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/0016-5085(92)90767-S","article-title":"Ulcer recurrence following duodenal ulcer healing with omeprazole, ranitidine or placebo: a double-blind, multicentre, 6-month study","volume":"102","author":"Graham, D.Y.; Colon-Pagan, J.; Morse, R.S.","year":"1992","unstructured":"Graham DY, Colon-Pagan J, Morse RS, et al. Ulcer recurrence following duodenal ulcer healing with omeprazole, ranitidine or placebo: a double-blind, multicentre, 6-month study. Gastroenterology 1992; 102: 1289-94.","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.7326\/0003-4819-116-9-705","article-title":"Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer","volume":"116","author":"Graham, D.Y.; Lew, G.M.; Klein, P.D.","year":"1992","unstructured":"Graham DY, Lew GM, Klein PD, et al. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. Ann Intern Med 1992; 116: 705-8.","journal-title":"Ann Intern Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(88)91961-7","article-title":"Recurrence of duodenal ulcer after medical treatment","volume":"1","author":"Lane, M.R.; Lee, S.P.","year":"1988","unstructured":"Lane MR, Lee SP. Recurrence of duodenal ulcer after medical treatment. Lancet 1988; 1: 1147-9.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2036.1992.tb00737.x","article-title":"Maintenance therapy in duodenal and gastric ulcer disease: a survey of practice amongst British gastroenterologists","volume":"6","author":"Boyd, E.J.S.; Penston, J.G.; Wormsley, K.G.","year":"1992","unstructured":"Boyd EJS, Penston JG, Wormsley KG. Maintenance therapy in duodenal and gastric ulcer disease: a survey of practice amongst British gastroenterologists. Aliment Pharmacol Ther 1992; 6: 727-37.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3109\/00365528909089269","article-title":"Efficacy and safety of long-term maintenance therapy of duodenal ulcers","volume":"24","author":"Penston, J.; Wormsley, K.G.","year":"1989","unstructured":"Penston J, Wormsley KG. Efficacy and safety of long-term maintenance therapy of duodenal ulcers. Scand J Gastroenterol 1989; 24: 1145-52.","journal-title":"Scand J Gastroenterol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/BF02088044","article-title":"RUDER - a prospective, two-year, multicentre study of risk factors for duodenal ulcer relapse during maintenance therapy with ranitidine","volume":"39","author":"Armstrong, D.; Arnold, R.; Classen, M.","year":"1994","unstructured":"Armstrong D, Arnold R, Classen M, et al. RUDER - a prospective, two-year, multicentre study of risk factors for duodenal ulcer relapse during maintenance therapy with ranitidine. Dig Dis Sci 1994; 39: 1425-33.","journal-title":"Dig Dis Sci"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1136\/gut.34.12.1662","article-title":"Two-year maintenance treatment of duodenal ulcer disease with ranitidine 150 mg: a prospective multicentre randomised study","volume":"34","author":"Ruszniewski, P.; Slama, A.; Pappo, M.; Mignon, M.","year":"1993","unstructured":"Ruszniewski P, Slama A, Pappo M, Mignon M. Two-year maintenance treatment of duodenal ulcer disease with ranitidine 150 mg: a prospective multicentre randomised study. Gut 1993; 34: 1662-5.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2036.1993.tb00096.x","article-title":"A placebo-controlled investigation of duodenal ulcer recurrence after withdrawal of long-term treatmnent with ranitidine","volume":"7","author":"Penston, J.G.; Dixon, J.S.; Boyd, E.J.S.; Wormsley, K.G.","year":"1993","unstructured":"Penston JG, Dixon JS, Boyd EJS, Wormsley KG. A placebo-controlled investigation of duodenal ulcer recurrence after withdrawal of long-term treatmnent with ranitidine. Aliment Pharmacol Ther 1993; 7: 259-65.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/bmj.308.6932.827","article-title":"Long-term acid suppressing therapy in general practice","volume":"308","author":"Ryder, S.D.; O'Reilly, S.; Miller, R.J.; Ross, J.; Jacyna, M.R.; Levi, A.J.","year":"1994","unstructured":"Ryder SD, O'Reilly S, Miller RJ, Ross J, Jacyna MR, Levi AJ. Long-term acid suppressing therapy in general practice. BMJ 1994; 308: 827-30.","journal-title":"BMJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1136\/bmj.302.6782.919","article-title":"Duodenal ulcer: the villain unmasked?","volume":"302","author":"Axon, A.T.R.","year":"1991","unstructured":"Axon ATR. Duodenal ulcer: the villain unmasked? BMJ 1991; 302: 919-20.","journal-title":"BMJ"},{"key":"ref_13","first-page":"140","article-title":"Helicobacter pylori, duodenitis and duodenal ulceration","volume-title":"pylori and gastroduodenal disease","author":"Wyatt, J.I.","year":"1992","unstructured":"Wyatt JI. Helicobacter pylori, duodenitis and duodenal ulceration. In: Rathbone BJ, Heatley RV, eds. Helicobacter pylori and gastroduodenal disease. 2nd edn. Oxford: Blackwell, 1992; pp. 140-9.","edition":"2nd edn"},{"issue":"196","key":"ref_14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/00365529309098334","article-title":"Eradication of Helicobacter pylori and its effect in peptic ulcer","volume":"28","author":"Bell, G.D.; Powell, K.U.","year":"1993","unstructured":"Bell GD, Powell KU. Eradication of Helicobacter pylori and its effect in peptic ulcer. Scand J Gastroenterol 1993; 28 (suppl 196): 7-11.","journal-title":"Scand J Gastroenterol"},{"key":"ref_15","first-page":"915","article-title":"The European 13C-urea breath test for the detection of Helicobacter pylori","volume":"3","author":"Logan, R.P.H.; Dill, S.; Bauer, F.E.","year":"1991","unstructured":"Logan RPH, Dill S, Bauer FE, et al. The European 13C-urea breath test for the detection of Helicobacter pylori. Eur J Gastroenterol Hepatol 1991; 3: 915-21.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/bmj.305.6852.502","article-title":"Randomised controlled trial of short term treatment to eradicate Helicobacter pylori in patients with duodenal ulcer","volume":"305","author":"Hosking, S.W.; Ling, T.K.W.; Yung, M.Y.","year":"1992","unstructured":"Hosking SW, Ling TKW, Yung MY, et al. Randomised controlled trial of short term treatment to eradicate Helicobacter pylori in patients with duodenal ulcer. BMJ 1992; 305: 502-4.","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01535722","article-title":"GSRS-a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease","volume":"33","author":"Svedlund, J.; Sjodin, I.; Dotevall, G.","year":"1988","unstructured":"Svedlund J, Sjodin I, Dotevall G. GSRS-a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 1988; 33: 129-34.","journal-title":"Dig Dis Sci"},{"key":"ref_18","author":"British National Formulary","year":"1994","unstructured":"British National Formulary. London: British Medical Association & Royal Pharmaceutical Society of Great Britain, 1994."},{"key":"ref_19","first-page":"1716","article-title":"Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori","volume":"87","author":"Chiba, N.; Rademaker, J.W.; Rao, B.V.; Hunt, R.H.","year":"1992","unstructured":"Chiba N, Rademaker JW, Rao BV, Hunt RH. Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori. Am J Gastroenterol 1992; 87: 1716-27.","journal-title":"Am J Gastroenterol"},{"key":"ref_20","first-page":"1","article-title":"One-week low-dose triple therapy: new standards for Helicobacter pylori treatment","volume":"7","author":"Goddard, A.; Logan, R.","year":"1995","unstructured":"Goddard A, Logan R. One-week low-dose triple therapy: new standards for Helicobacter pylori treatment. Eur J Gastroenterol Hepatol 1995; 7: 1-3.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1056\/NEJM199302043280503","article-title":"Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer","volume":"328","author":"Hentschel, E.; Brandstatter, G.; Dragosics, B.","year":"1993","unstructured":"Hentschel E, Brandstatter G, Dragosics B, et al. Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. N Engl J Med 1993; 328: 308-12.","journal-title":"N Engl J Med"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(90)91301-P","article-title":"Cure of duodenal ulcer associated with eradication of Helicobacter pylori","volume":"335","author":"Rauws, E.A.J.; Tytgat, G.N.J.","year":"1990","unstructured":"Rauws EAJ, Tytgat GNJ. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 1990; 335: 1233-5.","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2036.1992.tb00556.x","article-title":"Experience with triple anti-Helicobacter pylori eradication therapy - sideeffects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance","volume":"6","author":"Bell, G.D.; Powell, K.; Burridge, S.M.","year":"1992","unstructured":"Bell GD, Powell K, Burridge SM, et al. Experience with triple anti-Helicobacter pylori eradication therapy - sideeffects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance. Aliment Pharmacol Ther 1992; 6: 427-35.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_24","first-page":"183","article-title":"Effect of omeprazole on Helicobacter pylori","volume":"32","author":"Sharp, J.; Logan, R.P.H.; Walker, M.M.; Gummett, P.A.; Misiewicz, J.J.; Baron, J.H.","year":"1991","unstructured":"Sharp J, Logan RPH, Walker MM, Gummett PA, Misiewicz JJ, Baron JH. Effect of omeprazole on Helicobacter pylori. Gut 1991; 32: A183 [abstract].","journal-title":"Gut"},{"key":"ref_25","first-page":"199","article-title":"One year follow-up of duodenal ulcers after 1 week triple therapy for Helicobacter pylori","volume":"89","author":"Sung, J.J.Y.; Chung, S.C.S.; Ling, T.K.W.","year":"1994","unstructured":"Sung JJY, Chung SCS, Ling TKW, et al. One year follow-up of duodenal ulcers after 1 week triple therapy for Helicobacter pylori. Am J Gastroenterol 1994; 89: 199-202.","journal-title":"Am J Gastroenterol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000201117","article-title":"Role of Helicobacter pylori eradication in the prevention of peptic ulcer bleeding relapse","volume":"55","author":"Labenz, J.; Borsch, G.","year":"1994","unstructured":"Labenz J, Borsch G. Role of Helicobacter pylori eradication in the prevention of peptic ulcer bleeding relapse. Digestion 1994; 55: 19-23.","journal-title":"Digestion"},{"issue":"10","key":"ref_27","first-page":"30","article-title":"Antibacterial treatment of gastric ulcers - German gastric ulcer study","volume":"161","author":"Bayerdorffer, E.; Mannes, G.A.; Hochter, W.","year":"1992","unstructured":"Bayerdorffer E, Mannes GA, Hochter W, et al. Antibacterial treatment of gastric ulcers - German gastric ulcer study. Irish J Med Sci 1992; 161 (suppl 10): 30 [abstract].","journal-title":"Irish J Med Sci"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/gut.35.1.19","article-title":"Evidence for the essential role of Helicobacter pylori in gastric ulcer disease","volume":"35","author":"Labenz, J.; Borsch, G.","year":"1994","unstructured":"Labenz J, Borsch G. Evidence for the essential role of Helicobacter pylori in gastric ulcer disease. Gut 1994; 35: 19-22.","journal-title":"Gut"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/837\/413\/50219258\/postgradmedj-71-413.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/837\/413\/50219258\/postgradmedj-71-413.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:22:26Z","timestamp":1709868146000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/71\/837\/413\/7044111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7,1]]},"references-count":28,"journal-issue":{"issue":"837","published-online":{"date-parts":[[1995,7,1]]},"published-print":{"date-parts":[[1995,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.71.837.413","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,7]]},"published":{"date-parts":[[1995,7,1]]}}}