{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:11:53Z","timestamp":1761765113389},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"837","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Central pontine myelinolysis (CPM) is a rare condition characterised by spastic tetraparesis, pseudobulbar palsy and the \u2018locked-in syndrome\u2019. It is frequently fatal. We report a patient who developed CPM secondary to profound hyponatraemia and who recovered with no disability. Serial magnetic resonance imaging (MRI) demonstrated characteristic abnormalities within the pons at the onset of the disease, whereas computerised tomography was normal. Clinical improvement was followed six months later by progressive resolution of the MRI changes, with almost complete resolution after 18 months. Clinical and MRI findings correlate early in the course of CPM but clinical recovery predates MRI improvement by several months.<\/jats:p>","DOI":"10.1136\/pgmj.71.837.430","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"430-432","source":"Crossref","is-referenced-by-count":27,"title":["Central pontine myelinolysis: clinical and MRI correlates"],"prefix":"10.1093","volume":"71","author":[{"given":"P J","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Neurology, The Walton Centre for Neurology and Neurosurgery , Rice Lane, Liverpool L9 1AE , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Walton Centre for Neurology and Neurosurgery , Rice Lane, Liverpool L9 1AE , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archneurpsyc.1959.02340140020004","article-title":"Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholics and malnourished patients","volume":"81","author":"Adams, R.A.; Victor, M.; Mancall, E.L.","year":"1959","unstructured":"Adams RA, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholics and malnourished patients. Arch Neurol Psychiatry 1959; 81: 154-72.","journal-title":"Arch Neurol Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1212\/WNL.39.4.493","article-title":"Central pontine myelinolysis after liver transplantation","volume":"39","author":"Estol, C.J.; Faris, A.A.; Martinez, J.; Barmada, M.A.","year":"1989","unstructured":"Estol CJ, Faris AA, Martinez J, Barmada MA. Central pontine myelinolysis after liver transplantation. Neurology 1989; 39: 493-8.","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00314635","article-title":"Central pontine myelinolysis associated with low potassium level in alcoholism","volume":"237","author":"Bahr, M.; Sommer, N.; Petersen, D.; Wietholer, H.; Dichgans, J.","year":"1990","unstructured":"Bahr M, Sommer N, Petersen D, Wietholer H, Dichgans J. Central pontine myelinolysis associated with low potassium level in alcoholism. J Neurol 1990; 237: 275-6.","journal-title":"J Neurol"},{"key":"ref_4","first-page":"163","article-title":"Resolving MR features in osmotic myelinolysis (central pontine and extrapontine myelinolysis)","volume":"14","author":"Ho VB, Fitz CR, Yoder CC, Geyer CA","year":"1993","unstructured":"Ho VB, Fitz CR, Yoder CC, Geyer CA. Resolving MR features in osmotic myelinolysis (central pontine and extrapontine myelinolysis). Am J Neuroradiol 1993; 14: 163-7.","journal-title":"Am J Neuroradiol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00005792-199311000-00001","article-title":"Pontine and extrapontine myelinolysis: a neurologic disorder following rapid correction of hyponatraemia","volume":"72","author":"Karp, B.I.; Laureno, R.","year":"1993","unstructured":"Karp BI, Laureno R. Pontine and extrapontine myelinolysis: a neurologic disorder following rapid correction of hyponatraemia. Medicine 1993; 72: 359-73.","journal-title":"Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1136\/jnnp.52.5.675","article-title":"Magnetic resonance imaging in central pontine myelinolysis","volume":"52","author":"Thompson, P.D.; Miller, D.; Gledhill, R.F.; Rossor, M.N.","year":"1989","unstructured":"Thompson PD, Miller D, Gledhill RF, Rossor MN. Magnetic resonance imaging in central pontine myelinolysis. 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Am J Neuroradiol 1993; 14: 651-4.","journal-title":"Am J Neuroradiol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/jon19944147","article-title":"Central pontine myelinolysis with complete recovery","volume":"4","author":"Keilson, M.; Drexler, E.; Miller, A.; Bruining, K.","year":"1994","unstructured":"Keilson M, Drexler E, Miller A, Bruining K. Central pontine myelinolysis with complete recovery. J Neuroimaging 1994; 4: 47-8.","journal-title":"J Neuroimaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0140-6736(93)92343-R","article-title":"Central pontine myelinolysis after correction of chronic hyponatraemia","volume":"342","year":"1993","unstructured":"Lundboom N, Laurila 0, Laurila S. Central pontine myelinolysis after correction of chronic hyponatraemia. Lancet 1993; 342: 247-8.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ana.410110204","article-title":"Association between rise in serum sodium and central pontine myelinolysis","volume":"11","author":"Norenberg, M.D.; Leslie, K.O.; Robertson, A.S.","year":"1982","unstructured":"Norenberg MD, Leslie KO, Robertson AS. Association between rise in serum sodium and central pontine myelinolysis. Ann Neurol 1982; 11: 128-35.","journal-title":"Ann Neurol"},{"key":"ref_12","first-page":"262","article-title":"Central pontine and extrapontine myelinolysis: a report of 58 cases","volume":"6","author":"Gocht, A.; Colmant, H.J.","year":"1987","unstructured":"Gocht A, Colmant HJ. Central pontine and extrapontine myelinolysis: a report of 58 cases. Clin Neuropathol 1987; 6: 262-7.","journal-title":"Clin Neuropathol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ana.410270110","article-title":"Central pontine myelinolysis and pontine lesions after rapid correction of hyponatraemia: a prospective magnetic resonance imaging study","volume":"27","author":"Brunner, J.E.; Redmond, J.M.; Haggar, A.M.; Kruger, D.F.; Elias, S.B.","year":"1990","unstructured":"Brunner JE, Redmond JM, Haggar AM, Kruger DF, Elias SB. Central pontine myelinolysis and pontine lesions after rapid correction of hyponatraemia: a prospective magnetic resonance imaging study. 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J Comput Assist Tomogr 1988; 12: 446-9.","journal-title":"J Comput Assist Tomogr"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0002-9343(92)90748-Z","article-title":"Hyponatraemic encephalopathy: is central pontine myelinolysis a component?","volume":"92","author":"Tien, R.; Al, Arieff; Kucharczyk, W.; Wasik, A.; Kucharczyk, J.","year":"1992","unstructured":"Tien R, Arieff Al, Kucharczyk W, Wasik A, Kucharczyk J. Hyponatraemic encephalopathy: is central pontine myelinolysis a component? Am I Med 1992; 92: 513-22.","journal-title":"Am I Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/837\/430\/50219280\/postgradmedj-71-430.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/837\/430\/50219280\/postgradmedj-71-430.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T23:51:22Z","timestamp":1683762682000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/71\/837\/430\/7044101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7,1]]},"references-count":16,"journal-issue":{"issue":"837","published-online":{"date-parts":[[1995,7,1]]},"published-print":{"date-parts":[[1995,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.71.837.430","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,7]]},"published":{"date-parts":[[1995,7,1]]}}}