{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:06:23Z","timestamp":1761743183842},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"838","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eighty-nine consecutive patients attending for day-case colonoscopy were randomly allocated either polyethylene glycol\/balanced electrolyte (PEG) mixture (n = 45) or a mannitol\/Picolax mixture (n = 44). Both preparations were administered in two fractions. Patients recorded their experience of the preparation on a questionnaire and one of two experienced endoscopists (unaware of the type of preparation given) assessed the result of bowel cleansing. Carbon dioxide insufflation was used for all examinations. Good\/excellent bowel cleansing occurred in significantly more patients given PEG, 43 (96%), than those allocated mannitol\/Picolax, 34 (77%), p = 0.01. More patients receiving mannitol\/Picolax were able to complete the preparation in full than patients receiving PEG (38 vs 27, p = 0.01). More patients found the taste of mannitol\/Picolax pleasant compared to PEG (46% vs 20%). Both preparations had a similar side-effect profile. Of those patients tested, 13% receiving mannitol\/Picolax had a postural drop in blood pressure and blood parameters suggestive of mild dehydration. A fractionated administration of PEG as a bowel preparation for day-case colonoscopy is well tolerated and superior as a cleansing agent to a mannitol\/Picolax combination. Provided carbon dioxide is used as the insufflating agent, mannitol\/Picolax is an acceptable alternative in fit, young patients intolerant of PEG.<\/jats:p>","DOI":"10.1136\/pgmj.71.838.476","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"476-479","source":"Crossref","is-referenced-by-count":23,"title":["The quest for a more acceptable bowel preparation: comparison of a polyethylene glycol\/electrolyte solution and a mannitol\/Picolax mixture for colonoscopy"],"prefix":"10.1093","volume":"71","author":[{"given":"B P","family":"Saunders","sequence":"first","affiliation":[{"name":"Department of Endoscopy, St Mark's Hospital , City Road, London EC1V 2PS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, St Mark's Hospital , City Road, London EC1V 2PS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, St Mark's Hospital , City Road, London EC1V 2PS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Halligan","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, St Mark's Hospital , City Road, London EC1V 2PS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C B","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, St Mark's Hospital , City Road, London EC1V 2PS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/030006057700500515","article-title":"Preparation of the large bowel for endoscopy","volume":"5","author":"Teague, R.H.; Manning, A.P.","year":"1977","unstructured":"Teague RH, Manning AP. 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