{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:19:26Z","timestamp":1759565966519},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"840","license":[{"start":{"date-parts":[[1995,10,1]],"date-time":"1995-10-01T00:00:00Z","timestamp":812505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pregnancy following idiopathic aplastic anaemia is rare and is difficult to manage because of life-threatening episodes of bleeding and infections. Only a handful of cases has been reported in the literature. The pregnancies were unsuccessful in the majority. The present report describes a patient with moderately severe idiopathic aplastic anaemia who was managed with intensive haematological support leading to delivery of a healthy infant by caesarean section. Despite platelet transfusion refractoriness as a result of transfusions prior to pregnancy, adequate platelet transfusions prevented excessive bleeding. The literature is reviewed and management with platelet transfusions is discussed.<\/jats:p>","DOI":"10.1136\/pgmj.71.840.625","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"625-627","source":"Crossref","is-referenced-by-count":7,"title":["Successful pregnancy following aplastic anaemia"],"prefix":"10.1093","volume":"71","author":[{"given":"K W","family":"Leong","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Malaya , 59100 Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Malaya , 59100 Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Malaya , 59100 Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya , 59100 Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJM198203183061105","article-title":"Aplastic anaemia: pathogenesis, diagnosis, treatment and prognosis","volume":"306","author":"Camitta, B.M.; Storb, R.; Thomas, E.D.","year":"1982","unstructured":"Camitta BM, Storb R, Thomas ED. Aplastic anaemia: pathogenesis, diagnosis, treatment and prognosis. N Engl J Med 1982; 306: 645-52, 712-8.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2141.1988.tb02460.x","article-title":"Bone marrow transplantation versus immunosuppression for the treatment of severe aplastic anaemia: a report of the EBMT SAA working party","volume":"70","author":"Bacigalupo, A.; Hows, J.; Gluckman, E.","year":"1988","unstructured":"Bacigalupo A, Hows J, Gluckman E, et al. Bone marrow transplantation versus immunosuppression for the treatment of severe aplastic anaemia: a report of the EBMT SAA working party. Br J Haematol 1988; 70: 177-82.","journal-title":"Br J Haematol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0028-2243(92)90189-6","article-title":"Pregnancy in idiopathic aplastic anaemia (report of 10 patients)","volume":"45","author":"Pajor, A.; Kelemen, E.; Szakacs, Z.; Lehoczky, D.","year":"1992","unstructured":"Pajor A, Kelemen E, Szakacs Z, Lehoczky D. Pregnancy in idiopathic aplastic anaemia (report of 10 patients). Eur J Obstet Gynecol Reprod Biol 1992; 45: 19-25.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01880679","article-title":"Prognostic aspects of aplastic anaemia. Experience on six cases and review of the literature","volume":"36","author":"Suda, T.; Omine, M.; Tuchiya, J.; Maekawa, T.","year":"1978","unstructured":"Suda T, Omine M, Tuchiya J, Maekawa T. Prognostic aspects of aplastic anaemia. Experience on six cases and review of the literature. Blut 1978; 36: 285-98.","journal-title":"Blut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2141.1989.tb00294.x","article-title":"Pregnancy associated with aplastic anaemia: a report of five cases and review of current management","volume":"73","author":"Aitchison, R.G.; Marsh, J.C.; Hows, J.M.; Russel, N.H.; Gordon, S.","year":"1989","unstructured":"Aitchison RG, Marsh JC, Hows JM, Russel NH, Gordon S. Pregnancy associated with aplastic anaemia: a report of five cases and review of current management. Br J Haematol 1989; 73: 541-5.","journal-title":"Br J Haematol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1365-2141.1989.tb07757.x","article-title":"Factors influencing the transfusion response to HLA-selected apheresis donor platelets in patients refractory to random platelet concentrates","volume":"73","author":"McFarland, J.G.; Anderson, A.J.; Slichter, S.J.","year":"1989","unstructured":"McFarland JG, Anderson AJ, Slichter SJ. Factors influencing the transfusion response to HLA-selected apheresis donor platelets in patients refractory to random platelet concentrates. Br J Haematol 1989; 73: 380-6.","journal-title":"Br J Haematol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/840\/625\/50218936\/postgradmedj-71-625.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/840\/625\/50218936\/postgradmedj-71-625.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T01:12:22Z","timestamp":1683767542000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/71\/840\/625\/7044029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10,1]]},"references-count":6,"journal-issue":{"issue":"840","published-online":{"date-parts":[[1995,10,1]]},"published-print":{"date-parts":[[1995,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.71.840.625","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,10]]},"published":{"date-parts":[[1995,10,1]]}}}