{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:15:52Z","timestamp":1762017352083},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"841","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Somatostatinoma is one of the rarest tumours of the endocrine pancreas. Cardinal manifestations of a somatostatinoma include gallstones, mild diabetes mellitus, steatorrhoea, diarrhoea and dyspepsia. Like any other pancreatic islet cell carcinoma, a somatostatinoma may also produce several different hormones such as adrenocorticotropic hormone, calcitonin, vasoactive intestinal polypeptide, pancreatic polypeptide, gastrin, insulin, and glucagon. In many cases, the clinical picture is dominated by the effect of these other hormones. We present a patient with somatostatinoma in which an immunocytochemical study of the specimens from pancreas and liver showed a weak positive reaction for gastrin besides a strong positive reaction for somatostatin. Interestingly, this patient also showed the signs of carcinoid syndrome which was successfully treated with octreotide.<\/jats:p>","DOI":"10.1136\/pgmj.71.841.695","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:25:21Z","timestamp":1230585921000},"page":"695-698","source":"Crossref","is-referenced-by-count":4,"title":["Carcinoid syndrome due to a malignant somatostatinoma"],"prefix":"10.1093","volume":"71","author":[{"given":"O","family":"Ozbakir","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Erciyes University School of Medicine , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Kele\u015ftimur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erciyes University School of Medicine , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Ozt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erciyes University School of Medicine , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"S\u00f6z\u00fcer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erciyes University School of Medicine , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erciyes University School of Medicine , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T E","family":"Patiro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erciyes University School of Medicine , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"G\u00fcven","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erciyes University School of Medicine , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,11,1]]},"reference":[{"key":"ref_1","first-page":"249","article-title":"The inhibitory syndrome: somatostatinoma","volume-title":"endocrinology: clinical syndromes","author":"Estes, B.L.; Krejs, G.J.","year":"1990","unstructured":"Estes BL, Krejs GJ. The inhibitory syndrome: somatostatinoma. In: Friesen SR, Thompson NW, eds. Surgical endocrinology: clinical syndromes, 2nd edn. Philadelphia: JB Lippincott Company, 1990; pp 249-66.","edition":"2nd edn"},{"key":"ref_2","first-page":"1295","article-title":"Follow-up of a patient with somatostatinoma","volume":"315","author":"Krejs, G.J.; Collins, S.M.; McCarthy, D.; Unger, R.H.; Gardner, J.D.","year":"1986","unstructured":"Krejs GJ, Collins SM, McCarthy D, Unger RH, Gardner JD. Follow-up of a patient with somatostatinoma. N EnglJ3 Med 1986; 315: 1295."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1210\/jcem-56-6-1236","article-title":"Five cases of somatostatinoma: clinical heterogeneity and diagnostic usefulness of basal and tolbutamide-induced hypersomatostatinemia","volume":"56","author":"Pipeleers, D.; Couturier, E.; Gepts, W.","year":"1983","unstructured":"Pipeleers D, Couturier E, Gepts W, et al. Five cases of somatostatinoma: clinical heterogeneity and diagnostic usefulness of basal and tolbutamide-induced hypersomatostatinemia. J Clin Endocrinol Metab 1983; 56: 1236-42.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_4","first-page":"181","article-title":"The carcinoid syndromes","volume-title":"endocrinology: clinical syndromes","author":"Kaplan, E.L.; Udekwu, A.","year":"1990","unstructured":"Kaplan EL, Udekwu A. The carcinoid syndromes. In: Friesen SR, Thompson NW, eds. Surgical endocrinology: clinical syndromes, 2nd edn. Philadelphia: JB Lippincott Company, 1990; pp 181-209.","edition":"2nd edn"},{"key":"ref_5","first-page":"939","article-title":"Pancreatic somatostatinoma: histologic, clinical and angiographic features","volume":"133","author":"Gerlock, A.J.; Muhletaler, C.A.; Halter, S.; Goncharenko, V.","year":"1979","unstructured":"Gerlock AJ, Muhletaler CA, Halter S, Goncharenko V. Pancreatic somatostatinoma: histologic, clinical and angiographic features. AIR 1979; 133: 939-43.","journal-title":"AIR"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0140-6736(77)92113-4","article-title":"Pancreatic somatostatinoma: clinical features and physiological implications","volume":"1","author":"Larsson, L.I.; Hirsch, M.A.; Holst, J.J.","year":"1977","unstructured":"Larsson LI, Hirsch MA, Holst JJ, et al. Pancreatic somatostatinoma: clinical features and physiological implications. Lancet 1977; 1: 666-8.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1056\/NEJM197704282961703","article-title":"Somatostatinoma: a somatostatin-containing tumor of the endocrine pancreas","volume":"296","author":"Ganda, O.P.; Weir, G.C.; Soeldner, J.S.","year":"1977","unstructured":"Ganda OP, Weir GC, Soeldner JS, et al. Somatostatinoma: a somatostatin-containing tumor of the endocrine pancreas. N Engl J Med 1977; 296: 963-7.","journal-title":"N Engl J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1056\/NEJM197704282961713","volume":"296","author":"Somatostatinoma, Unger R.H.","year":"1977","unstructured":"Unger RH. Somatostatinoma. N Engl 7 Med 1977; 296: 998-1000.","journal-title":"N Engl 7 Med"},{"key":"ref_9","first-page":"30","article-title":"Pancreatic islet-cell carcinoma producing gastrin, ACTH, a-endorphin, somatostatin and calcitonin","volume":"74","author":"Asa, S.L.; Kovacs, K.; Killinger, D.W.","year":"1980","unstructured":"Asa SL, Kovacs K, Killinger DW, et al. Pancreatic islet-cell carcinoma producing gastrin, ACTH, a-endorphin, somatostatin and calcitonin. Am J Gastroenterol 1980; 74: 30-4.","journal-title":"Am J Gastroenterol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/841\/695\/50219282\/postgradmedj-71-695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/71\/841\/695\/50219282\/postgradmedj-71-695.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T01:40:53Z","timestamp":1683769253000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/71\/841\/695\/7044109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11,1]]},"references-count":9,"journal-issue":{"issue":"841","published-online":{"date-parts":[[1995,11,1]]},"published-print":{"date-parts":[[1995,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.71.841.695","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,11]]},"published":{"date-parts":[[1995,11,1]]}}}