{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:50Z","timestamp":1760189030923},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"845","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thyroid disease can roughly be divided into functional and anatomical disorders. Subclinical disease is by definition not accompanied by symptoms or signs and usually goes unrecognized for the bearer (and the observer). In this communication an overview will be given of existing literature and some own results concerning subclinical hypothyroidism, subclinical thyrotoxicosis and thyroid incidentalomas. Apart from definitions, data on prevalence, clinical effects, prognostic significance and the need for and response to therapy will be discussed.<\/jats:p>","DOI":"10.1136\/pgmj.72.845.141","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"141-146","source":"Crossref","is-referenced-by-count":5,"title":["Subclinical thyroid disease"],"prefix":"10.1093","volume":"72","author":[{"given":"J W","family":"Elte","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Sint Franciscus Gasthuis , 3045 PM Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A H","family":"Mudde","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Slingeland Ziekenhuis , Doetinchem , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Nieuwenhuijzen Kruseman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, University Hospital , Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/bmj.1.5854.657","article-title":"Grades of hypothyroidism","volume":"1","author":"Evered, D.C.; Ormston, B.J.; Smith, P.A.; Hall, R.; Bird, T.","year":"1973","unstructured":"Evered DC, Ormston BJ, Smith PA, Hall R, Bird T. 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BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1365-2265.1981.tb00699.x","article-title":"Spontaneous hypothyroidism in symptomless autoimmune thyroiditis. A long-term follow-up study","volume":"15","author":"Gordin, A.; Lamberg, B.A.","year":"1981","unstructured":"Gordin A, Lamberg BA. Spontaneous hypothyroidism in symptomless autoimmune thyroiditis. A long-term follow-up study. Clin Endocrinol 1981; 15: 537-43.","journal-title":"Clin Endocrinol"},{"key":"ref_8","first-page":"227","article-title":"Follow-up of 120 patients with subclinical hypothyroidism over more than 10 years: risk factors for overt disease analyzed by life-table analysis","volume-title":"Progress in thyroid research","author":"Engler, H.; Staub, J.-J.; Althaus, B.; Ryff, A.; Viollier, E.; Girard, J.","year":"1991","unstructured":"Engler H, Staub J-J, Althaus B, Ryff A, Viollier E, Girard J. Follow-up of 120 patients with subclinical hypothyroidism over more than 10 years: risk factors for overt disease analyzed by life-table analysis. In: Gordon A, Gross J, Hennemann G, eds. Progress in thyroid research, Rotterdam: Balkema, 1991; pp 227-9."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1001\/archinte.1993.00410080025004","article-title":"Subclinical hypothyroidism. Natural course of the syndrome during a prolonged follow-up study","volume":"153","author":"Kabadi, U.M.","year":"1993","unstructured":"Kabadi UM. Subclinical hypothyroidism. Natural course of the syndrome during a prolonged follow-up study. 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