{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:41Z","timestamp":1760189021763},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"848","license":[{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The prevalence of hypercalcaemia in the adult population is probably between 0.6 and 1.1%, sufferers being predominantly women over 50 years of age. Most apparently asymptomatic hypercalcaemic patients are found to have primary hyperparathyroidism, and may in fact show some symptoms of the condition (lowered bone mineral density, cardiovascular disease and\/or neuropsychiatric symptoms). The criteria for surgical intervention in these cases are discussed in the light of the high success rate of parathyroidectomy in experienced hands and the lack of effective alternative treatments.<\/jats:p>","DOI":"10.1136\/pgmj.72.848.323","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"323-326","source":"Crossref","is-referenced-by-count":8,"title":["Asymptomatic primary hyperparathyroidism"],"prefix":"10.1093","volume":"72","author":[{"given":"J C","family":"Birkenh\u00e4ger","sequence":"first","affiliation":[{"name":"Academisch Ziekenhuis, Inwendige Geneeskunde III, Erasmus University , Rotterdam , Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bouillon","sequence":"additional","affiliation":[{"name":"LEGENDO, Katholieke Universiteit Leuven , Gasthuisberg, Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198001243020402","article-title":"Primary hyperparathyroidism","volume":"302","author":"Heath, H.; Hodgson, S.F.; Kennedy, M.A.","year":"1980","unstructured":"Heath H, Hodgson SF, Kennedy MA. Primary hyperparathyroidism. N Engl J Med 1980; 302: 189-93.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2265.1992.tb01454.x","article-title":"Primary hyperparathyroidism: agressive or conservative treatment","volume":"36","author":"Davies, M.","year":"1992","unstructured":"Davies M. Primary hyperparathyroidism: agressive or conservative treatment. Clin Endocrinol 1992; 36: 325-32.","journal-title":"Clin Endocrinol"},{"issue":"2","key":"ref_3","first-page":"43","article-title":"Immunoassays for parathyroid hormone 1-84 in the diagnosis of hyperparathyroidism","volume":"6","author":"Nussbaum, SR, Potts; J.T.","year":"1991","unstructured":"Nussbaum SR, Potts JT. Immunoassays for parathyroid hormone 1-84 in the diagnosis of hyperparathyroidism. Jf Bone Miner Res 1991; 6(suppl 2): S43-S50.","journal-title":"Jf Bone Miner Res"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/clinchem\/36.2.271","article-title":"Immunoradiometric assay of parathyrin with polyclonal and monoclonal region-specific antibodies","volume":"36","author":"Bouillon, R.; Coopmans, W.; Degroote, D.E.H.; Radoux, D.; Eliard, P.H.","year":"1990","unstructured":"Bouillon R, Coopmans W, Degroote DEH, Radoux D, Eliard PH. Immunoradiometric assay of parathyrin with polyclonal and monoclonal region-specific antibodies. Clin Chem 1990; 36: 271-6.","journal-title":"Clin Chem"},{"key":"ref_5","first-page":"131","article-title":"Prevalence of hypercalcaemia in a health screening in Stockholm","author":"Christensson, T.; Helsstrom, K.; Wengle, B.; Alveryd, A.; Wikland, B.","year":"1976","unstructured":"Christensson T, Helsstrom K, Wengle B, Alveryd A, Wikland B. Prevalence of hypercalcaemia in a health screening in Stockholm. 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J Bone Miner Res 1991; 6(suppl 2): SIlI-SI 16.","journal-title":"J Bone Miner Res"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1136\/pgmj.69.814.640","article-title":"Parathyroid hormone-related protein as a tumour marker in humoral hypercalcemia associated with occult malignancy","volume":"69","author":"Hutchesson, A.C.; Dunne, F.; Bundred, N.J.; Gee, H.; Ratcliffe, W.A.","year":"1993","unstructured":"Hutchesson AC, Dunne F, Bundred NJ, Gee H, Ratcliffe WA. Parathyroid hormone-related protein as a tumour marker in humoral hypercalcemia associated with occult malignancy. Postgrad Med J 1993; 69: 640-2.","journal-title":"Postgrad Med J"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/0002-9343(71)90122-7","article-title":"Primary hyperparathyroidism: a prospective clinical study","volume":"50","author":"Purnell, D.C.; Smith, L.H.; Scholz, D.A.; Elveback, L.R.; Arnaud, C.","year":"1971","unstructured":"Purnell DC, Smith LH, Scholz DA, Elveback LR, Arnaud C. Primary hyperparathyroidism: a prospective clinical study. Am J Med 1971; 50: 670-8.","journal-title":"Am J Med"},{"key":"ref_10","first-page":"473","article-title":"Asymptomatic primary hyperparathyroidism","volume-title":"Mayo Clin Proc 1981; 56","author":"Scholz, D.A.; Purnell, D.C.","unstructured":"Scholz DA, Purnell DC. Asymptomatic primary hyperparathyroidism. Mayo Clin Proc 1981; 56: 473-8."},{"key":"ref_11","first-page":"1","article-title":"Mortality after surgery for primary hyperparathyroidism: a follow-up of 441 patients operated on from 1956 to 1979","volume":"102","author":"Palmer, A.; Adami, H.O.; Bergstrom, R.; Akerstrom, G.; Ljunghall, S.","year":"1987","unstructured":"Palmer A, Adami HO, Bergstrom R, Akerstrom G, Ljunghall S. Mortality after surgery for primary hyperparathyroidism: a follow-up of 441 patients operated on from 1956 to 1979. Surgery 1987; 102: 1-7.","journal-title":"Surgery"},{"key":"ref_12","first-page":"283","article-title":"Skeletal disease in primary hyperparathyroidism","volume":"4","author":"Silverberg, S.J.; Shane, E.; de la L, Cruz","year":"1989","unstructured":"Silverberg SJ, Shane E, Cruz de la L, et al. Skeletal disease in primary hyperparathyroidism. JBoneMinerRes 1989; 4: 283-91.","journal-title":"JBoneMinerRes"},{"issue":"2","key":"ref_13","first-page":"97","article-title":"Asymptomatic primary hyperparathyroidism discovered by multichannel biochemical screening: clinical course and considerations bearing on the need for surgical intervention","volume":"6","author":"Parfitt, A.M.; Rao, D.S.; Kleerekoper, M.","year":"1991","unstructured":"Parfitt AM, Rao DS, Kleerekoper M. Asymptomatic primary hyperparathyroidism discovered by multichannel biochemical screening: clinical course and considerations bearing on the need for surgical intervention. Jf Bone Miner Res 1991; 6 (suppl 2): S97-S101.","journal-title":"Jf Bone Miner Res"},{"key":"ref_14","first-page":"553","article-title":"Preoperative localization of parathyroid tissue in primary hyperparathyroidism","author":"Doppman, J.L.","year":"1994","unstructured":"Doppman JL. Preoperative localization of parathyroid tissue in primary hyperparathyroidism. In:. Bilezikan JP, Levine MA, Marcus R, eds. The parathyroids. New York: Raven Press, 1994; pp 553-65."},{"issue":"2","key":"ref_15","first-page":"165","article-title":"Proceedings ofthe NIH consensus development conference on diagnosis and management of asymptomatic primary hyperparathyroidism","volume":"6","author":"Potts, J.T.","year":"1991","unstructured":"Potts JT (ed). Proceedings ofthe NIH consensus development conference on diagnosis and management of asymptomatic primary hyperparathyroidism. Jf Bone Miner Res 1991; 6 (suppl 2): SI -S165.","journal-title":"Jf Bone Miner Res"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1001\/archinte.1987.00370110079012","article-title":"What is the clinical significance of bone loss in primary hyperparathyroidism?","volume":"147","author":"Kochersberger, G.; Buckley, N.J.; Leight, G.S.","year":"1987","unstructured":"Kochersberger G, Buckley NJ, Leight GS, et al. What is the clinical significance of bone loss in primary hyperparathyroidism? Arch Intern Med 1987; 147: 1951-3.","journal-title":"Arch Intern Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1001\/archinte.1990.00390190133021","article-title":"Long-term irreversibility of bone loss after surgery for primary hyperparathyroidism","volume":"150","author":"Martin, P.; Bergmann, P.; Gillet, C.; Fuss, M.; Corvilain, J.; van J, Geertruyden","year":"1990","unstructured":"Martin P, Bergmann P, Gillet C, Fuss M, Corvilain J, Geertruyden van J. Long-term irreversibility of bone loss after surgery for primary hyperparathyroidism. 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Am Jf Med 1981; 71: 371-84.","journal-title":"Am Jf Med"},{"key":"ref_20","first-page":"29","article-title":"Cardiovascular risk factors in primary hyperparathyroidism: a 15year follow-up of operated and unoperated cases","volume":"230","author":"Lind, L.; Jacobsson, S.; Palmer, M.; Lithell, H.; Wengle, B.; Ljunghall, S.","year":"1991","unstructured":"Lind L, Jacobsson S, Palmer M, Lithell H, Wengle B, Ljunghall S. Cardiovascular risk factors in primary hyperparathyroidism: a 15year follow-up of operated and unoperated cases. I Intern Med 1991; 230: 29 - 35.","journal-title":"I Intern Med"},{"key":"ref_21","first-page":"476","article-title":"Psychiatric morbidity in primary hyperparathyroidism. World J7 Surg","volume":"12","author":"Joborn, C.; Hetta, J.; Johansson, H.","year":"1988","unstructured":"Joborn C, Hetta J, Johansson H, et al. Psychiatric morbidity in primary hyperparathyroidism. 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Am J Med 1989; 87: 553-7.","journal-title":"Am J Med"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/archsurg.1994.01420270011002","article-title":"Primary hyperparathyroidism: low surgical morbidity support liberal attitude to operation","volume":"129","author":"Kjellman, M.; Sandelin, K.; Farnebo, L.-O.","year":"1994","unstructured":"Kjellman M, Sandelin K, Farnebo L-O. Primary hyperparathyroidism: low surgical morbidity support liberal attitude to operation. Arch Surg 1994; 129: 237-40.","journal-title":"Arch Surg"},{"key":"ref_25","first-page":"101","article-title":"Old age is not a contra-indication for surgery in patients with primary hyperparathyroidism","volume":"45","author":"Ruijs, C.D.M.; Ottow, R.T.; van Vroonhoven, T.J.M.V.","year":"1994","unstructured":"Ruijs CDM, Ottow RT, van Vroonhoven TJMV. Old age is not a contra-indication for surgery in patients with primary hyperparathyroidism. Neth Jf Med 1994; 45: 101-3.","journal-title":"Neth Jf Med"},{"key":"ref_26","first-page":"947","article-title":"Presidential address: 'Asymptomatic' primary hyperparathyroidism: is parathyroidectomy indicated?","volume":"116","author":"Clark, O.H.","year":"1994","unstructured":"Clark OH. Presidential address: 'Asymptomatic' primary hyperparathyroidism: is parathyroidectomy indicated? Surgery 1994; 116: 947-53.","journal-title":"Surgery"},{"key":"ref_27","first-page":"519","article-title":"Medical management of primary hyperparathyroidism","author":"Stock, J.L.; Marcus, R.","year":"1994","unstructured":"Stock JL, Marcus R. Medical management of primary hyperparathyroidism. In: Bilezikian JP, Levine MA, Marcus R, eds. The Parathyroids. New York: Raven Press, 1994; pp 519 - 29."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2265.1993.tb00349.x","article-title":"Ultrasonically guided chemical parathyroidectomy in patients with primary hyperparathyroidism: a follow-up study","volume":"38","author":"Karstrup, S.; Hegedis, L.; Holm, H.H.","year":"1993","unstructured":"Karstrup S, Hegedis L, Holm HH. Ultrasonically guided chemical parathyroidectomy in patients with primary hyperparathyroidism: a follow-up study. Clin Endocrinol 1993; 38: 523-30.","journal-title":"Clin Endocrinol"},{"key":"ref_29","first-page":"457","article-title":"Clinical presentation of primary hyperparathyroidism","author":"Bilezikian, J.P.; Silverberg, S.J.; Gartenberg, F.","year":"1994","unstructured":"Bilezikian JP, Silverberg SJ, Gartenberg F, et al. Clinical presentation of primary hyperparathyroidism. In: Bilezikian JP, Levine MA, Marcus R, eds. The parathyroids. New York: Raven Press, 1994; pp 457-69."},{"key":"ref_30","first-page":"724","article-title":"Asymptomatic primary hyperparathyroidism","volume":"15","author":"Harrison, B.J.; Wheeler, M.H.","year":"1991","unstructured":"Harrison BJ, Wheeler MH. Asymptomatic primary hyperparathyroidism. World 7 Surg 1991; 15: 724-9."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/72\/848\/323\/50220126\/postgradmedj-72-323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/72\/848\/323\/50220126\/postgradmedj-72-323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T05:01:19Z","timestamp":1683781279000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/72\/848\/323\/7046662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6,1]]},"references-count":30,"journal-issue":{"issue":"848","published-online":{"date-parts":[[1996,6,1]]},"published-print":{"date-parts":[[1996,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.72.848.323","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,6]]},"published":{"date-parts":[[1996,6,1]]}}}