{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:16:09Z","timestamp":1770722169435,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"850","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Oesophageal cancer is the fourth most common tumour in developing countries, comprising mainly squamous cell tumours, although the incidence of adenocarcinoma has increased enormously over the last decades. Surgical resection has long been acknowledged as the mainstay of treatment, and developments in surgical technique are reviewed. The roles of radiotherapy and chemotherapy in the management of oesophageal cancer remain unclear, especially as the majority of studies to date have been uncontrolled trials. We present an analysis of 601 patients who underwent resection for carcinoma of the oesophagus between 1970 and 1994 in the Department of Clinical Surgery, St James\u2019s Hospital, Dublin. The analysis shows clearly that, while peri-operative mortality continues to improve, conventional surgery offers little prospect of cure in the majority of cases. We have therefore embarked upon a prospective controlled trial of neoadjuvant chemoradiotherapy followed by surgery versus surgery alone in patients with adenocarcinoma or squamous cell tumours of the oesophagus. Preliminary results indicate that multi-modality treatment may have a valuable role to play in the treatment of carcinoma of the oesophagus.<\/jats:p>","DOI":"10.1136\/pgmj.72.850.458","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"458-463","source":"Crossref","is-referenced-by-count":5,"title":["Cancer of the oesophagus"],"prefix":"10.1093","volume":"72","author":[{"given":"T P","family":"Hennessy","sequence":"first","affiliation":[{"name":"Department of Clinical Surgery, Trinity Centre, St James\u2019s Hospital , Dublin 8 , Republic of Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,8,1]]},"reference":[{"key":"ref_1","first-page":"24","article-title":"Cancer of the oesophagus","volume":"7","author":"Crepsi, M.; Bogomoletz, V.W.; Munoz, N.; Peracchia, A.; Savary, M.","year":"1994","unstructured":"Crepsi M, Bogomoletz VW, Munoz N, Peracchia A, Savary M. Cancer of the oesophagus. Gastroenterol Int 1994; 7: 24-35.","journal-title":"Gastroenterol Int"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1001\/jama.1991.03460100089030","article-title":"Rising incidence of adenocarcinoma of the oesophagus and gastric cardia","volume":"265","author":"Blot, W.J.; Devesa, S.S.; Kneller, R.W.; Fraumeni, J.F.","year":"1991","unstructured":"Blot WJ, Devesa SS, Kneller RW, Fraumeni JF. Rising incidence of adenocarcinoma of the oesophagus and gastric cardia. JAMA 1991; 265: 1287-9.","journal-title":"JAMA"},{"key":"ref_3","first-page":"381","article-title":"Oesophageal squamous cell carcinoma: a critical review of surgery","volume":"67","author":"Earlam, R.; Cunha-Melo, JR","year":"1980","unstructured":"Earlam R, Cunha-Melo JR. Oesophageal squamous cell carcinoma: a critical review of surgery. BrJSurg 1980; 67: 381-91.","journal-title":"BrJSurg"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/bjs.1800770804","article-title":"Surgical therapy of oesophageal carcinoma","volume":"77","author":"Muller, J.M.; Erasmi, H.; Stelzner, M.; Zieren, U.; Pichlmaier, H.","year":"1990","unstructured":"Muller JM, Erasmi H, Stelzner M, Zieren U, Pichlmaier H. Surgical therapy of oesophageal carcinoma. BrJ Surg 1990; 77: 845-57.","journal-title":"BrJ Surg"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00000658-198007000-00008","article-title":"Treatment of carcinoma of the esophagus. Retrospective study of 2400 patients","volume":"192","author":"Giuli, R.; Gignoux, M.","year":"1980","unstructured":"Giuli R, Gignoux M. Treatment of carcinoma of the esophagus. Retrospective study of 2400 patients. Ann Surg 1980; 192: 44-52.","journal-title":"Ann Surg"},{"key":"ref_6","first-page":"1","article-title":"Surgical treatment of carcinoma of the oesophagus. A review of the results in 478 cases","volume":"30","author":"McKeown, K.C.","year":"1985","unstructured":"McKeown KC. Surgical treatment of carcinoma of the oesophagus. A review of the results in 478 cases. I R Coll Surg Edin 1985; 30: 1-14.","journal-title":"I R Coll Surg Edin"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0002-9610(87)90196-6","article-title":"Esophageal resection for cancer: the rationale of current practice","volume":"153","author":"Wong, J.","year":"1987","unstructured":"Wong J. Esophageal resection for cancer: the rationale of current practice. Am I Surg 1987; 153: 18-24.","journal-title":"Am I Surg"},{"key":"ref_8","first-page":"131","article-title":"Three-stage esophagectomy","volume-title":"ofsurgical oncology","author":"Hennessy, T.P.J.","year":"1995","unstructured":"Hennessy TPJ. Three-stage esophagectomy. In: Donohue JH, van Heerden JA, Monson JRT, eds. Atlas ofsurgical oncology. Oxford: Blackwell, 1995; pp 131-5."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0022-5223(19)38900-7","article-title":"En bloc resection for neoplasms of the esophagus and cardia","volume":"85","author":"Skinner, D.B.","year":"1983","unstructured":"Skinner DB. En bloc resection for neoplasms of the esophagus and cardia. J Thorac Cardiovasc Surg 1983; 85: 59-71.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_10","first-page":"617","article-title":"Curative surgery for oesophageal carcinoma","volume-title":"Surgery of the oesophagus","author":"Skinner, D.B.","year":"1988","unstructured":"Skinner DB. Curative surgery for oesophageal carcinoma. In: Jamieson GG, ed. Surgery of the oesophagus. Edinburgh: Churchill Livingstone, 1988; pp 617-22."},{"key":"ref_11","first-page":"8","article-title":"Technical aids in performing transhiatal blunt esophagectomy without thoracotomy. Abstracts of the International Society for Diseases of the Oesophagus","author":"Orringer, M.B.","year":"1983","unstructured":"Orringer MB. Technical aids in performing transhiatal blunt esophagectomy without thoracotomy. Abstracts of the International Society for Diseases of the Oesophagus, Rome, October 1983, E8 - 1."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/bjs.1800780521","article-title":"Chylothorax after oesophagectomy","volume":"78","author":"Bolger, K.; Walsh, T.N.; Tanner, W.A.; Keeling, P.; Hennessy, T.P.J.","year":"1991","unstructured":"Bolger K, Walsh TN, Tanner WA, Keeling P, Hennessy TPJ. Chylothorax after oesophagectomy. BrJ Surg 1991; 78: 587-8.","journal-title":"BrJ Surg"},{"key":"ref_13","first-page":"187","article-title":"Cervical-thoracic-abdominal lymph node dissection for intrathoracic esophageal carcinoma","volume-title":"Diseases of the esophagus: malignant diseases","author":"Tsurumaru, M.; Aliyama, H.; Udagawa, H.; Ono, Y.; Suzuki, M.; Watanabe, G.","year":"1990","unstructured":"Tsurumaru M, Aliyama H, Udagawa H, Ono Y, Suzuki M, Watanabe G. Cervical-thoracic-abdominal lymph node dissection for intrathoracic esophageal carcinoma. In: MK Ferguson, AG Little, DB Skinner, eds. Diseases of the esophagus: malignant diseases. New York: Futura Publishing Co. 1990; pp 187-96."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/978-3-642-86432-2_94","article-title":"Cardinals in the regional lymph node dissection in surgery of thoracic esophageal carcinoma","volume-title":"Diseases of the esophagus","author":"Akiyama, H.","year":"1988","unstructured":"Akiyama H. Cardinals in the regional lymph node dissection in surgery of thoracic esophageal carcinoma. In: Siewert JR, Holscher AH, eds. Diseases of the esophagus. Berlin: Springer-Verlag, 1988; pp 416-20."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0003-4975(91)91008-J","article-title":"Evaluation of neck lymph node dissection for thoracic esophageal carcinoma","volume":"51","author":"Kato, H.; Watanabe, Y.; Achimori, Y.; Izuka, T.","year":"1991","unstructured":"Kato H, Watanabe Y, Achimori Y, Izuka T. Evaluation of neck lymph node dissection for thoracic esophageal carcinoma. Ann Thorac Surg 1991; 51: 931-5.","journal-title":"Ann Thorac Surg"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000226971","article-title":"Result of a nationwide study on the three-field lymph node dissection of esophageal cancer","volume":"48","author":"Isono, K.; Sato, H.; Nakayama, K.","year":"1991","unstructured":"Isono K, Sato H, Nakayama K. Result of a nationwide study on the three-field lymph node dissection of esophageal cancer. Oncology 1991; 48: 411-20.","journal-title":"Oncology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/dote\/5.2.99","article-title":"Radical lymphadenectomy in esophageal cancer: does it improve survival?","volume":"5","author":"Desai, P.B.; Deshpande, R.K.; Patil, P.K.; Mistry, R.C.","year":"1992","unstructured":"Desai PB, Deshpande RK, Patil PK, Mistry RC. Radical lymphadenectomy in esophageal cancer: does it improve survival? Dis Esophagus 1992; 5: 99-104.","journal-title":"Dis Esophagus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1056\/NEJM199206113262403","article-title":"Combined chemotherapy and radiotherapy with radiotherapy alone in patients with cancer of the esophagus","volume":"326","author":"Herskovic, A.; Martaz, K.; al-Saraf, M.","year":"1992","unstructured":"Herskovic A, Martaz K, al-Saraf M, et al. Combined chemotherapy and radiotherapy with radiotherapy alone in patients with cancer of the esophagus. N EnglJ7 Med 1992; 326: 1593 - 8.","journal-title":"N EnglJ7 Med"},{"key":"ref_19","first-page":"6902","article-title":"Preoperative radiotherapy for carcinoma of the esophagus","volume":"153","author":"Launois, B.; Delarue, D.; Campion, J.P.","year":"1981","unstructured":"Launois B, Delarue D, Campion JP, et al. Preoperative radiotherapy for carcinoma of the esophagus. Surg Gynecol Obstet 1981; 153: 6902.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_20","first-page":"138","article-title":"Postoperative radiotherapy for carcinoma of the esophagus: a prospective randomised controlled study","volume":"113","author":"Fok, M.; Sham, J.S.T.; Choy, D.; Cheng, S.W.K.; Wong, J.","year":"1993","unstructured":"Fok M, Sham JST, Choy D, Cheng SWK, Wong J. Postoperative radiotherapy for carcinoma of the esophagus: a prospective randomised controlled study. Surgery, 1993; 113: 138-47.","journal-title":"Surgery"},{"key":"ref_21","first-page":"123","article-title":"Postoperative radiation does not increase survival after curative resection for squamous cell carcinoma of the middle and lower esophagus as shown by a multicenter controlled trial","volume":"173","author":"P, Research Tenier; J-M, Hay; A, Fingerhut; P-L, Fagniez","year":"1991","unstructured":"French University Association for Surgical Research. Tenier P, Hay J-M, Fingerhut A, Fagniez P-L. Postoperative radiation does not increase survival after curative resection for squamous cell carcinoma of the middle and lower esophagus as shown by a multicenter controlled trial. Surg Gynecol Obstet 1991; 173: 123 - 30.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1200\/JCO.1990.8.8.1352","article-title":"Preoperative therapy for esophageal cancer: a randomized comparison versus radiation therapy","volume":"8","author":"Kelsen, D.P.; Kinsky, B.; Smith, M.","year":"1990","unstructured":"Kelsen DP, Kinsky B, Smith M, et al. Preoperative therapy for esophageal cancer: a randomized comparison versus radiation therapy. J Clin Oncol 1990; 8: 1352-61.","journal-title":"J Clin Oncol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1200\/JCO.1987.5.4.622","article-title":"Combined therapies for squamous cell carcinoma of the esophagus; a Southwest Oncology Group Study (SWOG-8037)","volume":"5","author":"Poplin, E.; Fleming, T.; Leichman, L.","year":"1987","unstructured":"Poplin E, Fleming T, Leichman L, et al. Combined therapies for squamous cell carcinoma of the esophagus; a Southwest Oncology Group Study (SWOG-8037). Clin Oncol 1987; 5: 622-8.","journal-title":"Clin Oncol"},{"key":"ref_24","first-page":"243","article-title":"Carcinoma of the hypopharynx, esophagus and cardia","volume":"162","author":"Hennessy, T.P.J.; O'Connell, R.","year":"1986","unstructured":"Hennessy TPJ, O'Connell R. Carcinoma of the hypopharynx, esophagus and cardia. Surg Gynecol Obstet 1986; 162: 243-7.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_25","article-title":"Surgery for oesophageal carcinoma: studies on predicting and improving outcome","author":"Walsh, T.N.","year":"1995","unstructured":"Walsh TN. Surgery for oesophageal carcinoma: studies on predicting and improving outcome. MD Thesis, University of Dublin, Trinity College, 1995."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/72\/850\/458\/50220286\/postgradmedj-72-458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/72\/850\/458\/50220286\/postgradmedj-72-458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T05:12:18Z","timestamp":1683781938000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/72\/850\/458\/7043951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8,1]]},"references-count":25,"journal-issue":{"issue":"850","published-online":{"date-parts":[[1996,8,1]]},"published-print":{"date-parts":[[1996,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.72.850.458","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,8]]},"published":{"date-parts":[[1996,8,1]]}}}