{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:19:55Z","timestamp":1775881195320,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"850","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We report two patients whose thyrotoxicosis failed to respond to conventional treatment with carbimazole. The patients remained persistently hyperthyroid, both clinically and biochemically, despite several months of carbimazole therapy at the maximum recommended doses. Prednisolone 20 mg per day was then given in addition to the antithyroid drug and a dramatic response observed in both cases. They were then successfully treated with radioiodine. Prednisolone has not been previously used to treat patients with hyperthyroidism who have not responded to thionamide drugs. Our experience suggests that corticosteroids may be potentially useful for controlling thyrotoxicosis in combination with carbimazole before definite treatment can be instituted.<\/jats:p>","DOI":"10.1136\/pgmj.72.850.489","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"489-491","source":"Crossref","is-referenced-by-count":16,"title":["Treatment of thyrotoxicosis resistant to carbimazole with corticosteroids"],"prefix":"10.1093","volume":"72","author":[{"given":"E B","family":"Jude","sequence":"first","affiliation":[{"name":"Department of Medicine, Birmingham Heartlands Hospital , Birmingham B9 5SS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dale","sequence":"additional","affiliation":[{"name":"Department of Medicine, Birmingham Heartlands Hospital , Birmingham B9 5SS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Birmingham Heartlands Hospital , Birmingham B9 5SS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Dodson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Birmingham Heartlands Hospital , Birmingham B9 5SS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,8,1]]},"reference":[{"key":"ref_1","article-title":"Textbook of endocrinology","author":"Wilson, J.D.; Foster, D.W.","year":"1992","unstructured":"Wilson JD, Foster DW. Textbook of endocrinology, 8th edn. WB Saunders Co, 1992.","edition":"8th edn"},{"key":"ref_2","article-title":"The pharmacological basis of therapeutics","author":"Goodman, A.G.; Rall, T.W.; Nies, A.S.; Taylor, P.","year":"1991","unstructured":"Goodman AG, Rall TW, Nies AS, Taylor P. The pharmacological basis of therapeutics, 8th edn. Oxford: Pergamon Press, 1991.","edition":"8th edn"},{"key":"ref_3","first-page":"721","article-title":"Changing iodine intake and the effect on thyroid disease. BMJ'","volume":"294","author":"Hall, R.; Lazarus, J.H.","year":"1987","unstructured":"Hall R, Lazarus JH. Changing iodine intake and the effect on thyroid disease. BMJ' 1987; 294: 721-2."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/jcem-41-2-354","article-title":"Acute effects of corticosteroids on thyroid activity in Graves'","volume":"41","author":"Williams, D.E.; Chopra, I.J.; Orgiazzi, J.; Solomon, D.H.","year":"1975","unstructured":"Williams DE, Chopra IJ, Orgiazzi J, Solomon DH. Acute effects of corticosteroids on thyroid activity in Graves' disease. J Clin Endocrinol Metab 1975; 41: 354-61.","journal-title":"disease. J Clin Endocrinol Metab"},{"issue":"911 -20","key":"ref_5","article-title":"Opposite effects of dexamethazone on serum concentrations of 3,3',5'-triiodothyronine (reverse T3) and 3,3',5'-triiodothyronine (T3)","volume":"41","author":"Chopra, I.J.; Williams, D.E.; Orgiazzi, J.; Solomon, D.H.","year":"1975","unstructured":"Chopra IJ, Williams DE, Orgiazzi J, Solomon DH. Opposite effects of dexamethazone on serum concentrations of 3,3',5'-triiodothyronine (reverse T3) and 3,3',5'-triiodothyronine (T3). J Clin Endocninol Metab 1975; 41: 911 -20.","journal-title":"J Clin Endocninol Metab"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1210\/jcem-45-4-623","article-title":"Combination drug therapy for treatment of hyperthyroid Graves'","volume":"45","author":"Croxon, M.S.; Hall, T.D.; Nicoloff, J.T.","year":"1977","unstructured":"Croxon MS, Hall TD, Nicoloff JT. Combination drug therapy for treatment of hyperthyroid Graves' disease. JT Clin Endocrinol Metab 1977; 45: 623-30.","journal-title":"disease. JT Clin Endocrinol Metab"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1507\/endocrj1954.30.93","article-title":"Rapid improvement of thyroid function by using glucocorticoid indicated for the preoperative preparation of subtotal thyroidectomy in Graves'","volume":"30","author":"Ozawa, Y.; Daida, H.; Shimizu, T.; Shishiba, Y.","year":"1983","unstructured":"Ozawa Y, Daida H, Shimizu T, Shishiba Y. Rapid improvement of thyroid function by using glucocorticoid indicated for the preoperative preparation of subtotal thyroidectomy in Graves' disease. Endocrinol Japon 1983; 30: 93-100.","journal-title":"disease. Endocrinol Japon"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJM198701013160109","article-title":"Immunoregulation in autoimmune thyroid disease","volume":"316","author":"Volpe, R.","year":"1987","unstructured":"Volpe R. Immunoregulation in autoimmune thyroid disease. N Engl I Med 1987; 316: 44-6.","journal-title":"N Engl I Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/72\/850\/489\/50220057\/postgradmedj-72-489.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/72\/850\/489\/50220057\/postgradmedj-72-489.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T05:07:41Z","timestamp":1683781661000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/72\/850\/489\/7043923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8,1]]},"references-count":8,"journal-issue":{"issue":"850","published-online":{"date-parts":[[1996,8,1]]},"published-print":{"date-parts":[[1996,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.72.850.489","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,8]]},"published":{"date-parts":[[1996,8,1]]}}}