{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:05:57Z","timestamp":1792112757163,"version":"4.4.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"855","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,1,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Alcohol abuse is one of the most serious problems in public health and the Wernicke-Korsakoff syndrome is one of the gravest consequences of alcoholism. The pathology is often undiagnosed in its less evident presentations, therefore an accurate diagnostic approach is a critical step in treatment planning. Treatment is based on restoration of thiamine, although this is insufficient to prevent the psychological decline of a great number of patients. The cognitive impact of the pathology is derived from the interaction of alcoholic neurotoxicity, thiamine deficiency and personal susceptibility. In this article, the literature concerning Wernicke-Korsakoff syndrome is reviewed.<\/jats:p>","DOI":"10.1136\/pgmj.73.855.27","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"27-31","source":"Crossref","is-referenced-by-count":82,"title":["Wernicke-Korsakoff syndrome"],"prefix":"10.1093","volume":"73","author":[{"given":"C","family":"Zubaran","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Sul , Av Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Hospital S\u00e3o Lucas, Pontific\u00eda Universidade Cat\u00f3lica do Rio Grande do Sul , Av Ipiranga 6690\/412, 90610-000 Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Rodnight","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Sul , Av Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1997,1,1]]},"reference":[{"key":"ref_1","first-page":"821","article-title":"In: Principles of neurology","author":"Adams, R.D.; Victor, M.","year":"1989","unstructured":"Adams RD, Victor M. 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