{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:43:57Z","timestamp":1792147437830,"version":"4.4.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"856","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Pyoderma gangrenosum and Sweet's syndrome are classified as neutrophilic dermatoses as they exhibit intense dermal inflammatory infiltrates composed of neutrophils with little evidence of a primary vasculitis. They share several characteristics and respond to immunosuppressives. Aetiology is felt to represent a manifestation of altered immunologic reactivity. Patients with both conditions concurrently have been described. Diagnosis is based on clinical and histopathological findings. However, clinically the typical forms of the two conditions are quite distinct: pyoderma showing cutaneous ulceration with a purple undermined border and Sweet's syndrome having tender, erythematous, nonulcerated plaques and nodules. Approximately 50% of cases of pyoderma are associated with a specific systemic disorder. These include inflammatory bowel disease, rheumatoid arthritis, non-Hodgkin's lymphoma and myeloproliferative disorders. Many associations with Sweet's syndrome have been described, including acute myeloid leukaemia, myeloma and adenocarcinomas, and haematological malignancy. There is overlap between the two conditions with lesions categorised as Sweet's syndrome being clinically more characteristic of atypical pyoderma and vice versa. We believe that pyoderma and Sweet's syndrome represent a continuum of spectrum of disease. The reason for the clinical differences between the conditions is unclear and merits further investigation but may be explained by varying levels of intensity and extent of the inflammatory process. This review will describe the pathogenesis, clinical features, diagnosis, associations and treatment of the two conditions.<\/jats:p>","DOI":"10.1136\/pgmj.73.856.65","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"65-68","source":"Crossref","is-referenced-by-count":53,"title":["Neutrophilic dermatoses: pyoderma gangrenosum and Sweet's syndrome"],"prefix":"10.1093","volume":"73","author":[{"given":"J T","family":"Lear","sequence":"first","affiliation":[{"name":"Department of Dermatology, North Staffs NHS Trust , Stoke on Trent, ST4 7PA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Atherton","sequence":"additional","affiliation":[{"name":"Department of Medicine, North Staffs NHS Trust , Stoke on Trent, ST4 7PA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P H","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Dermatology, North Staffs NHS Trust , Stoke on Trent, ST4 7PA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1997,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0190-9622(83)70191-X","article-title":"Neutrophilic dermatosis of myeloproliferative disorders","volume":"9","author":"Caughman, W.; Ster, R.; Haynes, H.","year":"1983","unstructured":"Caughman W, Ster R, Haynes H. Neutrophilic dermatosis of myeloproliferative disorders. JAm Acad Dermatol 1983; 9: 751 - 8.","journal-title":"JAm Acad Dermatol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/1097-0142(19830415)51:8<1518::AID-CNCR2820510827>3.0.CO;2-U","article-title":"Acute febrile neutrophilic dermatosis (Sweet's syndrome) and myeloproliferative disorders","volume":"51","author":"Cooper, P.H.; Innes, D.J.; Greer, K.E.","year":"1983","unstructured":"Cooper PH, Innes DJ, Greer KE. Acute febrile neutrophilic dermatosis (Sweet's syndrome) and myeloproliferative disorders. Cancer 1983; 51: 1518-26.","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1001\/archderm.1972.01620040018003","article-title":"Pyoderma gangrenosum altered delayed hypersensitivity and polyarteritis","volume":"105","author":"Lazarus, G.L.; Goldsmith, L.A.; Rocklin, R.E.","year":"1972","unstructured":"Lazarus GL, Goldsmith LA, Rocklin RE, et al. Pyoderma gangrenosum altered delayed hypersensitivity and polyarteritis. Arch Dermatol 1972; 105: 46-51.","journal-title":"Arch Dermatol"},{"key":"ref_4","first-page":"1893","article-title":"Cutaneous vasculitis","volume-title":"Textbook of dermatology","volume":"3","author":"Ryan, T.J.","year":"1992","unstructured":"Ryan TJ. Cutaneous vasculitis. In: Rook AJ, Wilkinson DS, Ebling FJ, eds, Textbook of dermatology, 5th edn, vol 3. Oxford: Blackwell Scientific Publications, 1992; pp 1893-961.","edition":"5th edn"},{"key":"ref_5","first-page":"164","article-title":"Pyoderma gangrenosum and relapsing polychondritis in a patient with HIV infection","volume":"2","author":"Casas, M.A.S.; Doval, J.V.; Mejuto, F.C.","year":"1992","unstructured":"Casas MAS, Doval JV, Mejuto FC, et al. Pyoderma gangrenosum and relapsing polychondritis in a patient with HIV infection. 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(abstract) Arch Dermatol 1980; 116: 13.","journal-title":"(abstract) Arch Dermatol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1001\/archderm.1989.01670200077013","article-title":"Acute febrile neutrophilic dermatosis","volume":"125","author":"Delaporte, E.; Gavoau, D.J.; Piette, F.A.","year":"1989","unstructured":"Delaporte E, Gavoau DJ, Piette FA, et al. Acute febrile neutrophilic dermatosis. Arch Dermatol 1989; 125: 1101-4.","journal-title":"Arch Dermatol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2133.1989.tb01408.x","article-title":"Sweet's syndrome and malignancy: a case associated with multiple myeloma and review of the literature","volume":"121","author":"Berth-Jones, J.; Hutchinson, P.E.","year":"1989","unstructured":"Berth-Jones J, Hutchinson PE. Sweet's syndrome and malignancy: a case associated with multiple myeloma and review of the literature. 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Potassium iodide in erythema nodosum and other erythematous dermatoses. J Am Acad Dermatol 1988; 9: 77-81.","journal-title":"J Am Acad Dermatol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1365-2133.1992.tb14823.x","article-title":"Sweet's syndrome responding to cyclosporin","volume":"127","author":"Bourke, J.F.; Berth-Jones, J.; Graham-Brown, R.A.C.","year":"1992","unstructured":"Bourke JF, Berth-Jones J, Graham-Brown RAC. Sweet's syndrome responding to cyclosporin. Br J Dermatol 1992; 127: 36-8.","journal-title":"Br J Dermatol"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/1097-0142(197602)37:2<922::AID-CNCR2820370245>3.0.CO;2-P","article-title":"Febrile neutrophilic dermatosis in acute myelogenous leukaemia","volume":"37","author":"Klock, J.C.; Oken, R.L.","year":"1976","unstructured":"Klock JC, Oken RL. Febrile neutrophilic dermatosis in acute myelogenous leukaemia. Cancer 1976; 37: 922-7.","journal-title":"Cancer"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/73\/856\/65\/50220858\/postgradmedj-73-65.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/73\/856\/65\/50220858\/postgradmedj-73-65.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T05:52:06Z","timestamp":1683784326000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/73\/856\/65\/7042101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2,1]]},"references-count":27,"journal-issue":{"issue":"856","published-online":{"date-parts":[[1997,2,1]]},"published-print":{"date-parts":[[1997,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.73.856.65","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,2]]},"published":{"date-parts":[[1997,2,1]]}}}