{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:04:06Z","timestamp":1792148646466,"version":"4.4.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"856","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Forty-one consecutive cases of liver abscesses seen at the National University Hospital, Singapore from 1988 to 1994 were reviewed. Twenty-seven cases (65%) were pyogenic, six (15%) amoebic, two (5%) tuberculous and six (15%) indeterminate. The predominance of pyogenic abscesses is in marked contrast to previous studies from the region a decade ago in which amoebic abscesses were the commonest type. The commonest pathogen causing pyogenic abscess was Klebsiella pneumoniae. Two cases were due to Mycobacterium tuberculosis, and this organism needs to be actively looked for in smears and cultures of aspirated material. As the majority of organisms isolated were resistant to ampicillin, empirical antibiotic treatment for suspected pyogenic abscess should include gentamicin or a cephalosporin. Percutaneous needle aspiration of the abscess was performed for 85% of pyogenic abscesses and surgery was necessary in only two cases because of complications. We found that percutaneous aspiration of liver abscess is helpful to confirm the diagnosis, provides a better bacteriological culture yield, gives a good outcome, and may uncover clinically unsuspected conditions like malignancy and tuberculoma which may mimic the presentation of liver abscesses. We recommend routine cytological examination of aspirated abscess material as well as stains and cultures for acid-fast bacilli.<\/jats:p>","DOI":"10.1136\/pgmj.73.856.89","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"89-92","source":"Crossref","is-referenced-by-count":39,"title":["Tropical liver abscess"],"prefix":"10.1093","volume":"73","author":[{"given":"K G","family":"Yeoh","sequence":"first","affiliation":[{"name":"Department of Medicine, National University Hospital , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Hospital , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S T","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Hospital , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Pathology, National University Hospital , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Hospital , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Y","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Hospital , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1997,2,1]]},"reference":[{"key":"ref_1","first-page":"176","article-title":"Liver abscess - a clinical study","volume":"15","author":"Teh, L.B.; Ng, H.S.; Kwok, K.C.","year":"1986","unstructured":"Teh LB, Ng HS, Kwok KC, et al. Liver abscess - a clinical study. Ann Acad Med 1986; 15: 176-81.","journal-title":"Ann Acad Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/pgmj.63.741.551","article-title":"Liver abscess in the tropics: experience in the University Hospital, Kuala Lumpur","volume":"63","author":"Goh, K.L.; Wong, N.W.; Paramsothy, M.; Somasundaram, K.","year":"1987","unstructured":"Goh KL, Wong NW, Paramsothy M, Somasundaram K. Liver abscess in the tropics: experience in the University Hospital, Kuala Lumpur. Postgrad MedJ 1987; 63: 551-4.","journal-title":"Postgrad MedJ"},{"key":"ref_3","first-page":"282","article-title":"Management of hepatic abscess. Curr Probl Surg","volume":"18","author":"Balasegaram, M.","year":"1981","unstructured":"Balasegaram M. Management of hepatic abscess. Curr Probl Surg 1981; 18: 282-340."},{"key":"ref_4","first-page":"132","article-title":"Treatment of pyogenic liver abscess by percutaneous needle aspiration","volume":"1","year":"1982","unstructured":"Berger LA, Osborne DR. Treatment of pyogenic liver abscess by percutaneous needle aspiration. Lancet 1982; 1: 132-4.","journal-title":"Lancet"},{"key":"ref_5","first-page":"350","article-title":"Liver abscess: a two-year study","volume":"26","author":"Fock, K.M.; Ong, N.T.; Chua, K.L.","year":"1985","unstructured":"Fock KM, Ong NT, Chua KL. Liver abscess: a two-year study. Sing Med J 1985; 26: 350-3.","journal-title":"Sing Med J"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/BF01658732","article-title":"Pyogenic liver abscess-multivariate analysis of risk factors","volume":"15","author":"Lee, K.T.; Sheen, P.C.; Chen, J.S.; Ker, C.G.","year":"1991","unstructured":"Lee KT, Sheen PC, Chen JS, Ker CG. Pyogenic liver abscess-multivariate analysis of risk factors. World J Surg 1991; 15: 372-7.","journal-title":"World J Surg"},{"key":"ref_7","first-page":"1911","article-title":"Pyogenic liver abscess in Taiwan: emphasis on gas-forming liver abscess in diabetics","volume":"88","author":"Yang, C.C.; Chen, C.Y.; Lin, X.Z.; Chang, T.T.; Shin, J.S.; Lin, C.Y.","year":"1993","unstructured":"Yang CC, Chen CY, Lin XZ, Chang TT, Shin JS, Lin CY. Pyogenic liver abscess in Taiwan: emphasis on gas-forming liver abscess in diabetics. Am J Gastroenterol 1993 88: 1911-5.","journal-title":"Am J Gastroenterol"},{"key":"ref_8","first-page":"727","article-title":"Prognostic factors for pyogenic abscess of the liver","volume":"179","author":"Chou, F.F.; Sheen-Chen, S.M.; Chen, Y.S.; Chen, M.C.; Chen, F.C.; Tai, D.I.","year":"1994","unstructured":"Chou FF, Sheen-Chen SM, Chen YS, Chen MC, Chen FC, Tai DI. Prognostic factors for pyogenic abscess of the liver. JAm Coll Surg 1994; 179: 727-32.","journal-title":"JAm Coll Surg"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1445-2197.1990.tb07495.x","article-title":"Review of pyogenic liver abscess at the Royal Adelaide Hospital 1980-1987","volume":"60","author":"Karatassas, A.; Williams, J.A.R.","year":"1990","unstructured":"Karatassas A, Williams JAR. Review of pyogenic liver abscess at the Royal Adelaide Hospital 1980-1987. Aust NZJ Surg 1990; 60: 893-7.","journal-title":"Aust NZJ Surg"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archsurg.1991.01410320077010","article-title":"Pyogenic liver abscess: moder treatment","volume":"126","author":"Stain, S.C.; Yellin, A.E.; Donovan, A.J.; Brien, H.W.","year":"1991","unstructured":"Stain SC, Yellin AE, Donovan AJ, Brien HW. Pyogenic liver abscess: moder treatment. Arch Surg 1991; 126: 991 - 6.","journal-title":"Arch Surg"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/BF01659049","article-title":"Hepatic abscess","volume":"15","author":"Donovan, A.J.; Yellin, A.E.; Ralls, P.W.","year":"1991","unstructured":"Donovan AJ, Yellin AE, Ralls PW. Hepatic abscess. WorldJ Surg 1991; 15: 162-9.","journal-title":"WorldJ Surg"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00005792-198409000-00003","article-title":"Single and multiple pyogenic liver abscesses - natural history, diagnosis and treatment, with emphasis on percutaneous drainage","volume":"63","author":"McDonald, M.I.; Corey, G.R.; Gallis, H.A.; Durack, D.T.","year":"1984","unstructured":"McDonald MI, Corey GR, Gallis HA, Durack DT. Single and multiple pyogenic liver abscesses - natural history, diagnosis and treatment, with emphasis on percutaneous drainage. Medicine 1984; 63: 291-302.","journal-title":"Medicine"},{"key":"ref_13","first-page":"219","article-title":"Pyogenic hepatic abscess: a case for open drainage","volume":"59","author":"Hansen, N.; Vargish, T.","year":"1993","unstructured":"Hansen N, Vargish T. Pyogenic hepatic abscess: a case for open drainage. Am Surg 1993; 59: 219-22.","journal-title":"Am Surg"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/pgmj.70.824.436","article-title":"The changing clinical spectrum of liver abscess: the Jerusalem experience","volume":"70","author":"Yinnon, A.M.; Hadas-Halper, I.; Shapiro, M.; Hershko, C.","year":"1994","unstructured":"Yinnon AM, Hadas-Halper I, Shapiro M, Hershko C. The changing clinical spectrum of liver abscess: the Jerusalem experience. 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Radiology 1994; 190: 431-6.","journal-title":"Radiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0140-6736(82)90382-8","article-title":"Pyogenic liver abscesses - successful non-surgical therapy","volume":"1","author":"Herbert, D.A.; Rothman, J.; Simmons, F.","year":"1982","unstructured":"Herbert DA, Rothman J, Simmons F, et al. Pyogenic liver abscesses - successful non-surgical therapy. Lancet 1982; 1: 134-6.","journal-title":"Lancet"},{"key":"ref_20","first-page":"704","article-title":"Amebic liver abscess: a 15 year experience","volume":"86","author":"Maltz, G.; Knauer, C.M.","year":"1991","unstructured":"Maltz G, Knauer CM. Amebic liver abscess: a 15 year experience. Am J Gastroenterol 1991; 86: 704-10.","journal-title":"Am J Gastroenterol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1148\/radiology.165.3.3317505","article-title":"Medical treatment of hepatic amoebic abscess: rare need for percutaneous drainage","volume":"165","author":"Rails, P.W.; Barnes, P.F.; Johnson, M.B.","year":"1987","unstructured":"Rails PW, Barnes PF, Johnson MB, et al. Medical treatment of hepatic amoebic abscess: rare need for percutaneous drainage. Radiology 1987; 165: 805-7.","journal-title":"Radiology"},{"key":"ref_22","first-page":"315","article-title":"Contemporary management of amoebic liver abscess","volume":"58","author":"Nordestgaard, A.G.; Stapleford, L.; Worthen, N.; Bongard, F.S.; Klein, SR","year":"1992","unstructured":"Nordestgaard AG, Stapleford L, Worthen N, Bongard FS, Klein SR. Contemporary management of amoebic liver abscess. Am Surg 1992; 58: 315 - 20.","journal-title":"Am Surg"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF01308178","article-title":"Outcome of hepatic amebic abscesses managed with three different therapeutic strategies","volume":"37","author":"Filice, C.; Di Perri, G.; Strosselli, M.","year":"1992","unstructured":"Filice C, Di Perri G, Strosselli M, et al. Outcome of hepatic amebic abscesses managed with three different therapeutic strategies. Dig Dis Sci 1992; 37: 240-7.","journal-title":"Dig Dis Sci"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/pgmj.69.811.381","article-title":"Ultrasound-guided needle aspiration of amoebic liver abscess","volume":"69","author":"Ramani, A.; Ramani, R.; Kumar, M.S.; Lakhkar, B.N.; Kundaje, G.N.","year":"1993","unstructured":"Ramani A, Ramani R, Kumar MS, Lakhkar BN, Kundaje GN. Ultrasound-guided needle aspiration of amoebic liver abscess. Postgrad Med J 1993; 69: 381-3.","journal-title":"Postgrad Med J"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1148\/radiology.183.3.1584941","article-title":"Uncomplicated amebic liver abscess: prospective evaluation ofpercutaneous therapeutic aspiration","volume":"183","author":"RJ, Van Allan; MD, Katz; MB, Johnson; LA, Laine; Y, Liu; PW, Rails","year":"1992","unstructured":"Van Allan RJ, Katz MD, Johnson MB, Laine LA, Liu Y, Rails PW. Uncomplicated amebic liver abscess: prospective evaluation ofpercutaneous therapeutic aspiration. Radiology 1992; 183: 827-30.","journal-title":"Radiology"},{"key":"ref_26","first-page":"122","article-title":"Pyogenic liver abscesses: 13 years of experience in percutaneous needle aspiration with ultrasound guidance","author":"Giorgio, A.; Tarantino, L.; Mariniello, N.","year":"1995","unstructured":"Giorgio A, Tarantino L, Mariniello N, et al. Pyogenic liver abscesses: 13 years of experience in percutaneous needle aspiration with ultrasound guidance. Radiology 1995; 122-4.","journal-title":"Radiology"},{"key":"ref_27","first-page":"234","article-title":"Laparoscopyguided drainage of hepatic abscess","volume":"4","author":"Cappuccino, H.; Campanile, F.; Knecht, J.","year":"1994","unstructured":"Cappuccino H, Campanile F, Knecht J. Laparoscopyguided drainage of hepatic abscess. 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