{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:27:23Z","timestamp":1753921643367},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"863","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,9,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We have reviewed the incidence, type and site of microbiologically proven bacterial infection occurring in 52 patients with the acquired immunodeficiency syndrome (AIDS) who presented to Southmead Hospital, Bristol between 1990 and 1994. A total of 30 (58%) patients had significant bacterial isolates. The majority of infections were community acquired. Overall, more infections were caused by Gram-negative organisms but Gram-positive organisms predominated in bacteraemia. Mycobacterium avium intracellulare (MAI) caused infection in the largest number of patients, followed by Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas sp, and Campylobacter sp. When individual episodes of infection were considered, after MAI, Haemophilus influenzae, Streptococcus pneumoniae and Pseudomonas sp were the organisms most frequently isolated; often these same organisms caused recurrent chest infection. Bacterial infections in AIDS patients are common and although they generally respond well to antimicrobial chemotherapy there is a high recurrence rate, particularly in the respiratory tract, which is the commonest site of infection.<\/jats:p>","DOI":"10.1136\/pgmj.73.863.565","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"565-570","source":"Crossref","is-referenced-by-count":4,"title":["Microbiologically proven bacterial infections in AIDS"],"prefix":"10.1093","volume":"73","author":[{"given":"B L","family":"Kirkpatrick","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Southmead Health Services NHS Trust, Southmead Hospital , Westbury-on-Trym, Bristol BS10 5NB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S C","family":"Glover","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Southmead Health Services NHS Trust, Southmead Hospital , Westbury-on-Trym, Bristol BS10 5NB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D S","family":"Reeves","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Southmead Health Services NHS Trust, Southmead Hospital , Westbury-on-Trym, Bristol BS10 5NB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"MacGowan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Southmead Health Services NHS Trust, Southmead Hospital , Westbury-on-Trym, Bristol BS10 5NB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"ref_1","first-page":"221","article-title":"Bacterial infections and AIDS","volume":"87","author":"Fraser, V.","year":"1990","unstructured":"Fraser V. Bacterial infections and AIDS. Missouri Med 1990; 87: 221-4.","journal-title":"Missouri Med"},{"key":"ref_2","first-page":"377","article-title":"Bacterial and fungal infections in patients with the acquired immunodefiency syndrome","volume":"14","author":"Rolston, K.V.I.; Radentz, S.; Rodriguez, S.","year":"1990","unstructured":"Rolston KVI, Radentz S, Rodriguez S. Bacterial and fungal infections in patients with the acquired immunodefiency syndrome. Cancer Detect Prevent 1990; 14: 377-81.","journal-title":"Cancer Detect Prevent"},{"issue":"5","key":"ref_3","first-page":"53","article-title":"The changing clinical features of HIV-1 infection in the United Kingdom","volume":"4","author":"MaCarthy, G.A.; Mercey, D.","year":"1994","unstructured":"MaCarthy GA, Mercey D. The changing clinical features of HIV-1 infection in the United Kingdom. Commun Dis Rep 1994; 4 (5): 53-8.","journal-title":"Commun Dis Rep"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1056\/NEJM199105093241906","article-title":"Mycobacterium avium complex infection in the acquired immunodeficiency syndrome","volume":"324","author":"Horsburgh, C.R.","year":"1991","unstructured":"Horsburgh CR. Mycobacterium avium complex infection in the acquired immunodeficiency syndrome. N Engl J Med 1991; 324: 1332-8.","journal-title":"N Engl J Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0163-4453(93)91981-T","article-title":"Septicaemia in patients with and without AIDS at Westminster Hospital, London","volume":"27","author":"Hickey, M.M.; Shanson, D.C.","year":"1993","unstructured":"Hickey MM, Shanson DC. Septicaemia in patients with and without AIDS at Westminster Hospital, London. 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Indwelling central venous catheter infections in patients with acquired immune deficiency syndrome. 7 Acquir Immune Defic Syndr 1990; 3: 335 - 42.","journal-title":"7 Acquir Immune Defic Syndr"},{"key":"ref_8","first-page":"133","article-title":"Bacterial pneumonia in patients with human immunodeficiency virus infection","volume":"4","author":"Chaisson, R.E.","year":"1989","unstructured":"Chaisson RE. Bacterial pneumonia in patients with human immunodeficiency virus infection. Semin Respir Infect 1989; 4: 133-8.","journal-title":"Semin Respir Infect"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/0002-9343(89)90472-5","article-title":"Community acquired bacteraemia in patients with acquired immunodeficiency syndrome: clinical presentation, bacteriology and outcome","volume":"86","author":"Krumholz, H.M.; Sande, M.A.; Lo, B.","year":"1989","unstructured":"Krumholz HM, Sande MA, Lo B. Community acquired bacteraemia in patients with acquired immunodeficiency syndrome: clinical presentation, bacteriology and outcome. 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