{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:29:04Z","timestamp":1793298544868,"version":"4.5.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"864","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A survey of UK patients receiving the drug diazoxide, revealed 40 patients with insulinoma on this treatment. Mean age (\u00b1 SD) was 67 \u00b1 18 years, and 74% were female. Duration of treatment was 7 \u00b1 6 years (range 1\u201322). Most (55%) patients were treated with diazoxide because of tumour non-localisation (including failed previous surgery). Metastatic disease (20%) and poor surgical risk (10%) were other indications. Side-effects (notably fluid retention and hirsutism) were common (47%) but not troublesome. Treatment was highly effective\u201459% were symptom free and 38% had only occasional symptoms. Only one patient had frequent hypoglycaemia despite treatment. We conclude that diazoxide is effective in the management of insulinoma. Side-effects are common but not problematic. Treatment should be considered for all patients not cured by surgery, or unsuitable for surgical treatment.<\/jats:p>","DOI":"10.1136\/pgmj.73.864.640","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"640-641","source":"Crossref","is-referenced-by-count":144,"title":["Diazoxide treatment for insulinoma: a national UK survey"],"prefix":"10.1093","volume":"73","author":[{"given":"G V","family":"Gill","sequence":"first","affiliation":[{"name":"Department of Medicine, Walton Hospital , Rice Lane, Liverpool L9 1AE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Medicine, Walton Hospital , Rice Lane, Liverpool L9 1AE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I A","family":"MacFarlane","sequence":"additional","affiliation":[{"name":"Department of Medicine, Walton Hospital , Rice Lane, Liverpool L9 1AE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1997,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.me.30.020179.001525","article-title":"Diagnosis and medical management of insulinomas","volume":"30","author":"Fajans, S.S.; Floyd, J.C.","year":"1979","unstructured":"Fajans SS, Floyd JC. Diagnosis and medical management of insulinomas. Annu Rev Med 1979; 30: 313 - 29.","journal-title":"Annu Rev Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF02581941","article-title":"Problems of the management of insulinomas. Review of 132 cases treated with medical measures","volume":"11","author":"Stefanini, P.; Carboni, M.; Patrassi, N.; Bemardinis, G.D.; Negro, P.","year":"1974","unstructured":"Stefanini P, Carboni M, Patrassi N, Bemardinis GD, Negro P. Problems of the management of insulinomas. Review of 132 cases treated with medical measures. Acta Diabet Lat 1974; 11: 71-7.","journal-title":"Acta Diabet Lat"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1749-6632.1968.tb19055.x","article-title":"Clinical use of diazoxide and studies of the mechanism of its hyperglycaemic effects in man","volume":"150","author":"Graber, A.L.; Porte, D.; Williams, R.H.","year":"1968","unstructured":"Graber AL, Porte D, Williams RH. Clinical use of diazoxide and studies of the mechanism of its hyperglycaemic effects in man. Ann NYAcad Sci 1968; 150: 303-8.","journal-title":"Ann NYAcad Sci"},{"key":"ref_4","first-page":"157","article-title":"New perspectives on the action of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic beta-cell","volume":"20","year":"1994","unstructured":"Flatt PR, Shibier 0, Szecowka J, Berggren PO. New perspectives on the action of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic beta-cell. Diabete Metab 1994; 20: 157-62.","journal-title":"Diabete Metab"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/BF01655532","article-title":"Diazoxide in the management of patients with insulinoma","volume":"10","author":"Goode, P.N.; Farndon, JR, Anderson; J, Johnston; IDA, Morte; J.A.","year":"1986","unstructured":"Goode PN, Farndon JR, Anderson J, Johnston IDA, Morte JA. Diazoxide in the management of patients with insulinoma. World J Surg 1986; 10: 586 - 92.","journal-title":"World J Surg"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/73\/864\/640\/50223135\/postgradmedj-73-640.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/73\/864\/640\/50223135\/postgradmedj-73-640.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T05:05:18Z","timestamp":1683867918000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/73\/864\/640\/7061252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10,1]]},"references-count":5,"journal-issue":{"issue":"864","published-online":{"date-parts":[[1997,10,1]]},"published-print":{"date-parts":[[1997,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.73.864.640","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,10]]},"published":{"date-parts":[[1997,10,1]]}}}