{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:00:26Z","timestamp":1765666826311},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"865","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Audit of treatment of duodenal ulcer disease has allowed management to improve and keep abreast of rapid advances in care. Eradication of Helicobacter pylori was assessed by 14C urea breath test one to two months after anti-Helicobacter therapy. The old triple therapy regime of bismuth, tetracycline and metronidazole for two weeks was found to be toxic and of low effectiveness (82%). Regimes with lansoprazole for one month and antibiotics for one week gave 90\u201398% success rates. The best success has been with regimes containing both clarithromycin and a nitro-imidazole. There was complete success in 98% of 109 patients given quadruple therapy with lansoprazole 30 mg daily for one month plus tetracycline 500 mg twice daily, clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily for one week.<\/jats:p>","DOI":"10.1136\/pgmj.73.865.717","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"717-719","source":"Crossref","is-referenced-by-count":5,"title":["Improving management of duodenal ulcer disease"],"prefix":"10.1093","volume":"73","author":[{"given":"M C","family":"Bateson","sequence":"first","affiliation":[{"name":"Department of Medicine, General Hospital , Bishop Auckland, County Durham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B L","family":"Diffey","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Dryburn Hospital , County Durham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/gast.1996.v110.pm8613015","article-title":"Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review","volume":"110","author":"Hopkins, R.J.; Girardi, L.S.; Turney, E.A.","year":"1996","unstructured":"Hopkins RJ, Girardi LS, Turney EA. Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroenterology 1996; 110: 1244-52.","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1365-2036.1996.40182000.x","article-title":"Clinical aspects of Helicobacterpylori eradication therapy in peptic ulcer disease (review article)","volume":"10","author":"Penston, J.G.","year":"1996","unstructured":"Penston JG. Clinical aspects of Helicobacterpylori eradication therapy in peptic ulcer disease (review article). Aliment Pharmacol Ther 1996; 10: 469-86.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_3","first-page":"1","volume":"89","author":"pylori, Marshall B.J.Helicobacter","year":"1994","unstructured":"Marshall BJ. Helicobacter pylori. Am Jf Gastroenterol 1994; 89: S1 16-28.","journal-title":"Am Jf Gastroenterol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2036.1994.tb00303.x","article-title":"Treatments that impact favourably upon the eradication of Helicobacter pylori and ulcer recurrence (Review article)","volume":"8","author":"Tytgat GNJ","year":"1994","unstructured":"Tytgat GNJ. Treatments that impact favourably upon the eradication of Helicobacter pylori and ulcer recurrence (Review article). Aliment Pharmacol Ther 1994; 8: 359-68.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_5","first-page":"743","article-title":"Helicobacter pylori eradication: efficacy and side effect profile of a combination of omeprazole, amoxycillin and metronidazole compared with four alternative regimens","volume":"86","author":"Bell, G.D.; Powell, K.U.; Burridge, S.M.","year":"1993","unstructured":"Bell GD, Powell KU, Burridge SM, et al. Helicobacter pylori eradication: efficacy and side effect profile of a combination of omeprazole, amoxycillin and metronidazole compared with four alternative regimens. Q J Med 1993; 86: 743 - 50.","journal-title":"Q J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/00042737-199409000-00004","article-title":"Short-term low-dose triple therapy for the eradication of Helicobacter pylori","volume":"6","author":"Bazzoli, F.; Zagari, R.M.; Fossi, S.","year":"1994","unstructured":"Bazzoli F, Zagari RM, Fossi S, et al. Short-term low-dose triple therapy for the eradication of Helicobacter pylori. Eur J Gastroenterol Hepatol 1994; 6: 773 - 7.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1365-2036.1996.721101000.x","article-title":"High effectiveness and safety of one-week antibiotic regimen in Helicobacter pylori eradication","volume":"10","author":"M, Dalla Libera; P, Pazzi; G, Carli","year":"1996","unstructured":"Dalla Libera M, Pazzi P, Carli G, et al. High effectiveness and safety of one-week antibiotic regimen in Helicobacter pylori eradication. Aliment Pharmacol Ther 1996; 10: 203 - 6.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(95)92962-2","article-title":"Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection","volume":"345","author":"de Boer W; W, Driessen; A, Jansz; G, Tytgat","year":"1995","unstructured":"de Boer W, Driessen W, Jansz A, Tytgat G. Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection. Lancet 1995; 345: 817-20.","journal-title":"Lancet"},{"key":"ref_9","first-page":"461","article-title":"Serological diagnosis of H pylori - evaluation of 4 tests","volume":"34","author":"Taha, A.S.; Reid, J.; Boothmann, P.","year":"1993","unstructured":"Taha AS, Reid J, Boothmann P, et al. Serological diagnosis of H pylori - evaluation of 4 tests. Gut 1993; 34: 461 - 5.","journal-title":"Gut"},{"key":"ref_10","first-page":"467","article-title":"Diagnostic efficiency of an ultra-rapid endoscopy room test for Helicobacter pylori","volume-title":"Gut","volume":"32","author":"Thillainayagam, A.V.; Arvind, A.S.; Coom, R.S.; Harrison, I.G.; Tabaqchali, S.; Farthing, M.J.G.","year":"1991","unstructured":"Thillainayagam AV, Arvind AS, Coom RS, Harrison IG, Tabaqchali S, Farthing MJG. Diagnostic efficiency of an ultra-rapid endoscopy room test for Helicobacter pylori. Gut 1991; 32: 467-9."},{"key":"ref_11","first-page":"915","article-title":"The European 13Curea breath test for the detection of Helicobacter pylori","volume":"3","author":"Logan, R.P.H.; Dill, S.; Bauer, F.E.","year":"1991","unstructured":"Logan RPH, Dill S, Bauer FE, et al. The European 13Curea breath test for the detection of Helicobacter pylori. Eur3r Gastroenterol Hepatol 1991; 3: 915 - 21."},{"key":"ref_12","first-page":"438","article-title":"A 20-minute breath test for Helicobacter pylori","volume":"86","author":"Marshall, B.J.; Plankey, M.W.; Hoffman, SR","year":"1991","unstructured":"Marshall BJ, Plankey MW, Hoffman SR, et al. A 20-minute breath test for Helicobacter pylori. Am J Gastroenterol 1991; 86: 438-44.","journal-title":"Am J Gastroenterol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/gast.1996.v110.pm8613015","article-title":"Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review","volume":"110","author":"Hopkins, R.J.; Girardi, L.S.; Tumey, E.A.","year":"1996","unstructured":"Hopkins RJ, Girardi LS, Tumey EA. Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroentrology 1996; 110: 1244-52.","journal-title":"Gastroentrology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/gut.40.3.302","article-title":"The Helicobacter pylori Breath Test: a surrogate marker for peptic ulcer disease in dyspeptic patients","volume":"40","author":"McColl, K.E.L.; El-Nujumi, A.; Murrray, L.","year":"1997","unstructured":"McColl KEL, El-Nujumi A, Murrray L, et al. The Helicobacter pylori Breath Test: a surrogate marker for peptic ulcer disease in dyspeptic patients. Gut 1997; 40: 302-6.","journal-title":"Gut"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/73\/865\/717\/50221171\/postgradmedj-73-717.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/73\/865\/717\/50221171\/postgradmedj-73-717.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T05:26:35Z","timestamp":1683869195000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/73\/865\/717\/7059819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11,1]]},"references-count":14,"journal-issue":{"issue":"865","published-online":{"date-parts":[[1997,11,1]]},"published-print":{"date-parts":[[1997,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.73.865.717","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,11]]},"published":{"date-parts":[[1997,11,1]]}}}