{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T06:10:22Z","timestamp":1683871822458},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"866","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We report here, we believe for the first time, the primary antiphospholipid syndrome, presenting with fever, meningismus and skin rash. Serology was positive for antiphospholipid antibodies but negative for antinuclear factor. Such presentations, once meningitis has been excluded, should be screened for antiphospholipid antibodies. If serology proves to be positive, anticoagulation for life should be considered to avoid thrombotic episodes and death due to pulmonary embolism.<\/jats:p>","DOI":"10.1136\/pgmj.73.866.815","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"815-816","source":"Crossref","is-referenced-by-count":0,"title":["Meningismus, fever and macular rash as presenting features of the primary antiphospholipid syndrome?"],"prefix":"10.1093","volume":"73","author":[{"given":"T","family":"Houghton","sequence":"first","affiliation":[{"name":"Department of General Medicine, Bronglais General Hospital , Aberystwyth, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Bronglais General Hospital , Aberystwyth, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/bmj.287.6399.1088","article-title":"Thrombosis, abortion, cerebral disease and lupus anticoagulant","volume":"287","author":"Hughes, G.R.V.","year":"1983","unstructured":"Hughes GRV. Thrombosis, abortion, cerebral disease and lupus anticoagulant. BMJ 1983; 287: 1088-9.","journal-title":"BMJ"},{"key":"ref_2","first-page":"47","article-title":"Cerebral infarction in SLE: association with anticardiolipin antibody. Clin Exp Rheumatol","volume":"2","author":"Harris, E.N.; Gharavi, A.E.; Asherson, R.A.; Boey, M.L.; Hughes, G.R.V.","year":"1984","unstructured":"Harris EN, Gharavi AE, Asherson RA, Boey ML, Hughes GRV. Cerebral infarction in SLE: association with anticardiolipin antibody. Clin Exp Rheumatol 1984; 2: 47-51."},{"key":"ref_3","first-page":"535","article-title":"Connective tissue disease and the shin. Clin Exp Dernatol","volume":"9","author":"Hughes, G.R.V.","year":"1984","unstructured":"Hughes GRV. Connective tissue disease and the shin. Clin Exp Dernatol 1984; 9: 535 - 44."},{"key":"ref_4","first-page":"416","article-title":"Pulmonary hypertension in SLE: a report of 3 cases","volume":"12","author":"Asherson, R.A.; Mackworth-Young, C.G.; Boey, M.L.; Harris, E.N.; Hughes, G.R.V.","year":"1986","unstructured":"Asherson RA, Mackworth-Young CG, Boey ML, Harris EN, Hughes GRV. Pulmonary hypertension in SLE: a report of 3 cases. J Rheumatol 1986; 12: 416-8.","journal-title":"J Rheumatol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/01443618509067758","article-title":"Foetal loss in systemic lupus: association with anticardiolipin antibodies","volume":"5","author":"Deme, G.J.; Englert, J.H.; Harris, E.N.","year":"1985","unstructured":"Deme GJ, Englert JH, Harris EN, et al. Foetal loss in systemic lupus: association with anticardiolipin antibodies. J Obstet Gynecol 1985; 5: 207-9.","journal-title":"J Obstet Gynecol"},{"key":"ref_6","first-page":"486","article-title":"The anticardiolipin syndrome","volume":"13","author":"Hughes, G.R.V.; Harris, E.N.; Gharavi, A.E.","year":"1986","unstructured":"Hughes GRV, Harris EN, Gharavi AE. The anticardiolipin syndrome. J Rheumatol 1986; 13: 486-9.","journal-title":"J Rheumatol"},{"key":"ref_7","first-page":"423","article-title":"Stroke and meningitis in a case of SLE with antiphospholipid antibodies","volume":"35","author":"Watanabe, T.; Satoh, M.A.T.; Hayashi, M.; Otla, Y.","year":"1993","unstructured":"Watanabe T, Satoh MAT, Hayashi M, Otla Y. Stroke and meningitis in a case of SLE with antiphospholipid antibodies. Acta PaediatrJpn 1993; 35: 423-5.","journal-title":"Acta PaediatrJpn"},{"key":"ref_8","first-page":"644","article-title":"Thrombotic cerebral arteriopathy in patients with the antiphospholipid syndrome","volume":"6","author":"Hughson, M.D.; McCarty, G.A.; Sholer, C.M.; Brunback, R.A.","year":"1993","unstructured":"Hughson MD, McCarty GA, Sholer CM, Brunback RA. Thrombotic cerebral arteriopathy in patients with the antiphospholipid syndrome. Mod Pathol 1993; 6: 644-53.","journal-title":"Mod Pathol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/73\/866\/815\/50221206\/postgradmedj-73-815.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/73\/866\/815\/50221206\/postgradmedj-73-815.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T05:39:42Z","timestamp":1683869982000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/73\/866\/815\/7061206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12,1]]},"references-count":8,"journal-issue":{"issue":"866","published-online":{"date-parts":[[1997,12,1]]},"published-print":{"date-parts":[[1997,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.73.866.815","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,12]]},"published":{"date-parts":[[1997,12,1]]}}}