{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T06:40:27Z","timestamp":1683873627305},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"870","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 24 year old woman living in the Mediterranean region of Turkey present with a three-month history of weight loss and irregular fever that was peaking at 40 degrees C with shivering. No definite aetiology could be identified in a local hospital. A bacterial infection had been suspected, but antibiotic therapy, at first with sulbactam-ampicillin and later with azithromycin, had no influence on the fever. Physical examination revealed an emaciated patient with fever (39 degrees C), pallor, and hepatosplenomegaly (spleen 9 cm and liver 5 cm palpable below the costal margin). No peripheral lymphadenopathy was present. The laboratory examinations are summarised in the table. Notably, a prominent increase of macrophages containing intracellular micro-organisms (figures 1 and 2) was seen in the bone marrow smears. The same micro-organisms were also identified within the Kupffer cells in liver biopsy.<\/jats:p>","DOI":"10.1136\/pgmj.74.870.237","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"237-239","source":"Crossref","is-referenced-by-count":2,"title":["Fever, hepatosplenomegaly and pancytopenia in a patient living in the Mediterranean region"],"prefix":"10.1093","volume":"74","author":[{"given":"Y","family":"B\u00fcy\u00fcka\u015fik","sequence":"first","affiliation":[{"name":"Department of Adult Haematology, Hacettepe University Medical School , Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N S","family":"Ileri","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Numune Hospital , Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130 C","family":"Haznedaro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Adult Haematology, Hacettepe University Medical School , Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Demiro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Adult Haematology, Hacettepe University Medical School , Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"D\u00fcndar","sequence":"additional","affiliation":[{"name":"Department of Adult Haematology, Hacettepe University Medical School , Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/clind\/24.4.684","article-title":"Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years","volume":"24","author":"Berman, J.D.","year":"1997","unstructured":"Berman JD. Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin Infect Dis 1997;24:684-703.","journal-title":"Clin Infect Dis"},{"key":"ref_2","article-title":"The leishmaniases. Report of a WHO expert committee","volume":"701","author":"World Health Organization","year":"1984","unstructured":"World Health Organization. The leishmaniases. Report of a WHO expert committee. WHO Tech Rep Ser 1984; no 701."},{"key":"ref_3","first-page":"25","article-title":"Leishmaniasis: report of 33 cases and a review of the literature","volume":"16","author":"Bouree, P.; Belec, L.","year":"1993","unstructured":"Bouree P, Belec L. Leishmaniasis: report of 33 cases and a review of the literature. Comp Immun Microbiol Infect Dis 1993;16:25 1-65.","journal-title":"Comp Immun Microbiol Infect Dis"},{"key":"ref_4","first-page":"1245","article-title":"The six diseases of WHO. Leishmaniasis","volume":"283","author":"Chance, M.L.","year":"1981","unstructured":"Chance ML. The six diseases of WHO. Leishmaniasis. BMJ7 1981;283: 1245-7."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/bmj.303.6798.336","article-title":"Imported and autochthonous kala-azar in France","volume":"303","author":"Jeannel, D.; Tuppin, P.; Brucker, G.; Danis, M.; Gentilini, M.","year":"1991","unstructured":"Jeannel D, Tuppin P, Brucker G, Danis M, Gentilini M. Imported and autochthonous kala-azar in France. BMJ 1991;303:336-8.","journal-title":"BMJ"},{"key":"ref_6","first-page":"16","article-title":"Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma","volume":"322","author":"Badaro, R.; Falcoff, E.; Badaro, F.S.","year":"1990","unstructured":"Badaro R, Falcoff E, Badaro FS, et al. Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. NEnglJ3Med 1990;322:16-21."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/74\/870\/237\/50221925\/postgradmedj-74-237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/74\/870\/237\/50221925\/postgradmedj-74-237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T06:04:06Z","timestamp":1683871446000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/74\/870\/237\/7060981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4,1]]},"references-count":6,"journal-issue":{"issue":"870","published-online":{"date-parts":[[1998,4,1]]},"published-print":{"date-parts":[[1998,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.74.870.237","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,4]]},"published":{"date-parts":[[1998,4,1]]}}}