{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:12:59Z","timestamp":1761559979200},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"874","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The effect of ursodeoxycholic acid treatment on survival in primary biliary cirrhosis was studied in 40 patients with symptomatic disease. Two patients developed early exacerbation of symptoms and stopped therapy in days; they are both alive 4 and 4\u00bd years later. The other 38 patients have continued on treatment for up to 10 years. Results were compared with 12 other similar cases previously seen but not given specific therapy. Kaplan-Meier analysis showed that ursodeoxycholic acid treatment was associated with better survival (p &amp;lt;0.05) after the first two years of therapy. Predictors of favourable outcome included histological stage I disease. In 26 patients with primary biliary cirrhosis stage II, III or IV, therapy showed a trend to improved survival, but this was still significantly worse than the general population. Prognosis was not different between these different advanced stages. Symptoms improved in 28 out of 40 patients on ursodeoxycholic acid, but 50% had a recurrence by two years.<\/jats:p>","DOI":"10.1136\/pgmj.74.874.482","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"482-485","source":"Crossref","is-referenced-by-count":12,"title":["Ursodeoxycholic acid therapy for primary biliary cirrhosis. A 10-year British single-centre population-based audit of efficacy and survival"],"prefix":"10.1093","volume":"74","author":[{"given":"M C","family":"Bateson","sequence":"first","affiliation":[{"name":"Bishop Auckland General Hospital , Bishop Auckland, County Durham DL14 6AD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Gedling","sequence":"additional","affiliation":[{"name":"Bishop Auckland General Hospital , Bishop Auckland, County Durham DL14 6AD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1056\/NEJM199611213352107","article-title":"Medical progress: primary biliary cirrhosis","volume":"335","author":"Kaplan, M.M.","year":"1996","unstructured":"Kaplan MM. Medical progress: primary biliary cirrhosis. N EnglJMed 1996;335:1570-80.","journal-title":"N EnglJMed"},{"key":"ref_2","first-page":"834","article-title":"Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?","volume":"1","author":"Poupon, R.; Poupon, R.E.; Calmus, Y.; Chretien, Y.; Ballet, F.; Darnis, D.","year":"1987","unstructured":"Poupon R, Poupon RE, Calmus Y, Chretien Y, Ballet F, Darnis D. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? Lancet 1987;1:834-6.","journal-title":"Lancet"},{"key":"ref_3","article-title":"Liver biopsy intepretation","author":"Scheuer, P.J.; Lefkowitch, J.H.","year":"1994","unstructured":"Scheuer PJ, Lefkowitch JH. Liver biopsy intepretation. London: WB Saunders, 1994"},{"key":"ref_4","first-page":"305","article-title":"Ursodeoxycholic acid therapy and biliary lipids - a dose response study","volume-title":"Gut","volume":"21","author":"Bateson, M.C.; Ross, P.E.; Murison, J.; Saunders, J.H.B.; Bouchier, I.A.D.","year":"1980","unstructured":"Bateson MC, Ross PE, Murison J, Saunders JHB, Bouchier IAD. Ursodeoxycholic acid therapy and biliary lipids - a dose response study. Gut 1980;21:305-10."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1053\/gast.1996.v110.pm8613058","article-title":"Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis","volume":"110","author":"Lindor, K.D.; Therneau, T.M.; Jorgensen, R.A.; Malinchoc, M.; Dickson, R.E.","year":"1996","unstructured":"Lindor KD, Therneau TM, Jorgensen RA, Malinchoc M, Dickson RE. Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis. 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Ursodiol for the long-term treatment of primary biliary cirrhosis. NEnglJMed 1994;330: 1342-7.","journal-title":"NEnglJMed"},{"key":"ref_8","first-page":"884","article-title":"Combined analysis of randomised controlled trials of","volume-title":"UDCA in PBC. Gastroenterology 1997; 113","author":"Poupon, R.E.; lindor KD; Cauch-Dudek, K.; Dickson, E.R.; Poupon, R.; Heathcote, E.J.","unstructured":"Poupon RE, lindor KD, Cauch-Dudek K, Dickson ER, Poupon R, Heathcote EJ. Combined analysis of randomised controlled trials of UDCA in PBC. Gastroenterology 1997;113:884-90."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0168-8278(05)80139-4","article-title":"Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years","volume":"20","author":"Mahl, T.C.; Shockcor, Boyer; J.L.","year":"1994","unstructured":"Mahl TC, Shockcor, Boyer JL. Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years. J Hepatol 1994;20:707-13.","journal-title":"J Hepatol"},{"key":"ref_10","first-page":"1399402","article-title":"Natural history of early primary biliary cirrhosis","volume":"348","author":"Metcalf, J.V.; Mitchison, H.C.; Palmer, J.M.","year":"1996","unstructured":"Metcalf JV, Mitchison HC, Palmer JM, et al. Natural history of early primary biliary cirrhosis. Lancet 1996;348:1399402.","journal-title":"Lancet"},{"key":"ref_11","first-page":"1567","article-title":"Diminished survival asymptomatic PBC. A prospective study","volume":"98","author":"Balasubramanian, K.; Grambsch, P.M.; Wiesner, R.H.; Lindor, K.D.; Dickson, E.R.","year":"1990","unstructured":"Balasubramanian K, Grambsch PM, Wiesner RH, Lindor KD, Dickson ER. Diminished survival asymptomatic PBC. A prospective study. 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