{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:38:23Z","timestamp":1697665103426},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"877","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Barrett's oesophagus represents the replacement of stratified squamous epithelium by metaplastic columnar epithelium for 3 cm of the distal oesophagus. Gastro-oesophageal reflux, which affects 40% of the adult population, is the principal aetiological factor. This results in predominantly acid but also bile reflux (due to duodenogastrooesophageal reflux) through the lower oesophageal sphincter, transient relaxation of which accounts for the main mechanism of reflux. Conventional Barrett's oesophagus is reported in 11\u201313% of patients with symptomatic reflux and short segment Barrett's oesophagus (&amp;lt; 3.0 cm) in 18%. Approximately 50% of these patients have recognised complications on presentation, eg, carcinoma (15%). The disparity between clinical symptoms and endoscopic severity is due to reduced oesophageal mucosal sensitivity as a consequence of prolonged mucosal acid exposure. These rather alarming figures combined with the knowledge that Barrett's oesophagus is a pre-malignant condition (the diagnosis is associated with a 25\u2013130-fold increase of malignancy) may account for the substantial increase in junctional gastrooesophageal malignancies. Symptomatic Barrett's oesophagus should be managed with full-dose proton pump inhibitors, eg, lansoprazole. Anti-reflux surgery should be reserved for the medically fit patient with recurrent symptomatic relapse in the histological absence of premalignant change. There is no evidence suggesting that surgery can be used as a prophylactic measure against malignancy. Encouraging short-term results have been obtained with photodynamic therapy in the management of high-grade dysplasia. However, columnar epithelium has been found underlying the regenerated squamous epithelium, suggesting that life-long surveillance is warranted.<\/jats:p>","DOI":"10.1136\/pgmj.74.877.653","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:49:00Z","timestamp":1230587340000},"page":"653-657","source":"Crossref","is-referenced-by-count":4,"title":["Barrett's oesophagus"],"prefix":"10.1093","volume":"74","author":[{"given":"R M","family":"Navaratnam","sequence":"first","affiliation":[{"name":"University Department of Surgery, Royal Free Hospital , London NW3 2QG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Winslet","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Royal Free Hospital , London NW3 2QG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/dote\/8.2.93","article-title":"Malignant degeneration of Barrett's esophagus: malignant potential of 'shortsegment' Barrett's esophagus","volume":"8","author":"Hogan, W.J.","year":"1995","unstructured":"Hogan WJ. Malignant degeneration of Barrett's esophagus: malignant potential of 'shortsegment' Barrett's esophagus. Dis Esophagus 1995;8:93-8.","journal-title":"Dis Esophagus"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/bjs.18003815005","article-title":"Chronic peptic ulcer of the oesophagus and oesophagitis","volume":"38","author":"Barrett, N.R.","year":"1950","unstructured":"Barrett NR. Chronic peptic ulcer of the oesophagus and oesophagitis. Br J Surg 1950;38:175-82.","journal-title":"Br J Surg"},{"issue":"87-101","key":"ref_3","first-page":"47680","article-title":"The esophagus lined with gastric mucous membrane","volume":"8","author":"Allison, P.R.; Johnston, A.S.","year":"1953","unstructured":"Allison PR, Johnston AS. The esophagus lined with gastric mucous membrane. Thorax 1953;8: 87-101 4 Paull A, Trier JS, Dalton MD, Camp RC, Loeb P, Goyal RK. The histological spectrum of Barrett's oesophagus. N EnglJ Med 1976;295:47680.","journal-title":"Thorax; The histological spectrum of Barrett's oesophagus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1055\/s-2007-1010420","article-title":"Epidemiologic studies and the development of Barrett's esophagus","volume":"25","author":"Cameron, A.J.","year":"1993","unstructured":"Cameron AJ. Epidemiologic studies and the development of Barrett's esophagus. Endoscopy 1993;25:635-6.","journal-title":"Endoscopy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/archsurg.1983.01390050027005","article-title":"Barrett's esophagus: functional assessment, proposed pathogenesis, and surgical therapy","volume":"118","author":"Iascone, C.; DeMeester, T.R.; Little, A.G.","year":"1983","unstructured":"Iascone C, DeMeester TR, Little AG, et al. Barrett's esophagus: functional assessment, proposed pathogenesis, and surgical therapy. Arch Surg 1983;118:543-9.","journal-title":"Arch Surg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0016-5085(92)91510-B","article-title":"Barrett's esophagus: age, prevalence, and extent of columnar epithelium","volume":"103","author":"Cameron, A.J.; Lomboy, C.T.","year":"1992","unstructured":"Cameron AJ, Lomboy CT. Barrett's esophagus: age, prevalence, and extent of columnar epithelium. Gastroenterology 1992;103:1241-5.","journal-title":"Gastroenterology"},{"key":"ref_7","first-page":"1331","volume-title":"Barrett's esophagus in childhood. Gastroenterology 1985; 89","author":"Hassal, E.; Weinstein, W.M.; Ament, M.E.","unstructured":"Hassal E, Weinstein WM, Ament ME. Barrett's esophagus in childhood. Gastroenterology 1985; 89:1331-7."},{"key":"ref_8","first-page":"1494","article-title":"Barrett's oesophagus in patients with symptomatic reflux oesophagitis","volume":"84","author":"Mann, N.S.; Tsai, M.F.; Nair, P.K.","year":"1989","unstructured":"Mann NS, Tsai MF, Nair PK. Barrett's oesophagus in patients with symptomatic reflux oesophagitis. Am J Gastroenterol 1989;84:1494-6.","journal-title":"Am J Gastroenterol"},{"key":"ref_9","first-page":"157","article-title":"Endoscopic screening for Barrett's esophagus, esophageal adenocarcinoma, and other mucosal changes in ambulatory subjects with symptomatic gastroesophageal reflux","volume":"88","author":"Schnell, T.; Sontag, S.; Wanner, J.; Chintam, R.; Chejfec, G.; O'Connel, J.","year":"1985","unstructured":"Schnell T, Sontag S, Wanner J, Chintam R, Chejfec G, O'Connel J. Endoscopic screening for Barrett's esophagus, esophageal adenocarcinoma, and other mucosal changes in ambulatory subjects with symptomatic gastroesophageal reflux. Gastroenterology 1985;88:A157.","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1046\/j.1365-2036.1997.00181.x","article-title":"Review article: current practise and future perspectives in the management of gastro oesophageal reflux disease","volume":"11","author":"Lambert, R.","year":"1997","unstructured":"Lambert R. Review article: current practise and future perspectives in the management of gastro oesophageal reflux disease. Aliment Pharmacol Ther 1997;11:651-62.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/dote\/8.2.99","article-title":"Malignant degeneration of Barrett's esophagus: the role of the p53 tumour-suppressor-gene","volume":"8","author":"Schneider, P.M.; Casson, A.G.; Roth, J.A.","year":"1995","unstructured":"Schneider PM, Casson AG, Roth JA. Malignant degeneration of Barrett's esophagus: the role of the p53 tumour-suppressor-gene. Dis Esophagus 1995;8:99-103.","journal-title":"Dis Esophagus"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/bjs.1800840606","article-title":"High-grade dysplasia in Barrett's oesophagus","volume":"84","author":"Wright, T.A.","year":"1997","unstructured":"Wright TA. High-grade dysplasia in Barrett's oesophagus. BrJ Surg 1997;84:760-6.","journal-title":"BrJ Surg"},{"key":"ref_13","first-page":"223","article-title":"Management of gastro oesophageal reflux disease 1995. Pathophysiological basis of therapy for gastro oesophageal reflux disease","volume":"7","author":"Richter, J.E.","year":"1994","unstructured":"Richter JE. Management of gastro oesophageal reflux disease 1995. Pathophysiological basis of therapy for gastro oesophageal reflux disease. 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BrJ Surg 1988; 75:113-5.","journal-title":"BrJ Surg"},{"key":"ref_18","first-page":"411","article-title":"Bile reflux in columnar-lined Barrett's oesophagus","volume":"75","author":"Iftikhar, S.Y.; Ledingham, S.; Steele, R.J.","year":"1993","unstructured":"Iftikhar SY, Ledingham S, Steele RJ, et al. Bile reflux in columnar-lined Barrett's oesophagus. Ann R Coil Surg 1993;75:411-6.","journal-title":"Ann R Coil Surg"},{"key":"ref_19","first-page":"747","article-title":"Duodenogastroesophageal reflux: relationship to pH and importance","volume-title":"Barrett's esophagus. Gastroenterology","volume":"107","author":"Champion, G.; E, Richter J.; F, Vaezi M.; Singh, S.; Alexander, R.","year":"1994","unstructured":"Champion G, Richter J E, Vaezi M F, Singh S, Alexander R. Duodenogastroesophageal reflux: relationship to pH and importance in Barrett's esophagus. Gastroenterology 1994;107:747-54."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/gut.40.1.9","article-title":"Evaluation of Helicobacter pylori in reflux oesophagitis and Barrett's oesophagus","volume":"40","author":"Newton, M.; Bryan, R.; Burnham, W.R.; Kamm, M.A.","year":"1997","unstructured":"Newton M, Bryan R, Burnham WR, Kamm MA. Evaluation of Helicobacter pylori in reflux oesophagitis and Barrett's oesophagus. Gut 1997;40:9-13.","journal-title":"Gut"},{"key":"ref_21","first-page":"176","article-title":"Helicobacter pylori infection in patients with Barrett's oesophagus: a prospective immunohistochemical study. J7 Clin Pathol","volume":"49","author":"Ricaurte 0, Flejou JF, Vissuzaine C","year":"1996","unstructured":"Ricaurte 0, Flejou JF, Vissuzaine C, et al. Helicobacter pylori infection in patients with Barrett's oesophagus: a prospective immunohistochemical study. 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Dis Esophagus 1995;8:86-92.","journal-title":"Dis Esophagus"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1001\/archinte.1991.00400110070014","article-title":"Barrett's esophagus: prevalence and incidence of adenocarcinoma","volume":"151","author":"Williamson, W.A.; Ellis, F.H.; Gibb, S.P.","year":"1991","unstructured":"Williamson WA, Ellis FH, Gibb SP, et al. Barrett's esophagus: prevalence and incidence of adenocarcinoma. Arch Intern Med 1991;151: 2212-6.","journal-title":"Arch Intern Med"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0016-5085(84)80012-8","article-title":"Barrett's esophagus: clinical, endoscopic, histologic, manometric and electrical potential difference characteristics","volume":"86","author":"Herlihy, K.J.; Orlando, R.C.; Bryson, J.C.; Bozymski, E.M.; Carney, C.N.; Powell, D.W.","year":"1984","unstructured":"Herlihy KJ, Orlando RC, Bryson JC, Bozymski EM, Carney CN, Powell DW. Barrett's esophagus: clinical, endoscopic, histologic, manometric and electrical potential difference characteristics. Gastroenterology 1984;86:436-43.","journal-title":"Gastroenterology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/dote\/8.2.109","article-title":"Malignant degeneration of Barrett's esophagus: the role of laser ablation and anti-reflux surgery","volume":"8","author":"Salo, J.A.","year":"1995","unstructured":"Salo JA. Malignant degeneration of Barrett's esophagus: the role of laser ablation and anti-reflux surgery. Dis Esophagus 1995;8:109-10.","journal-title":"Dis Esophagus"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00004836-198702000-00006","article-title":"Esophageal acid sensibility in Barrett's esophagus","volume":"9","author":"Johnson, D.A.; Winters, C.; Spurling, T.J.; Chobanian, S.J.; Cattau, E.L.","year":"1987","unstructured":"Johnson DA, Winters C, Spurling TJ, Chobanian SJ, Cattau EL. Esophageal acid sensibility in Barrett's esophagus. Jf Clin Gastroenterol 1987;9:23-7.","journal-title":"Jf Clin Gastroenterol"},{"key":"ref_28","first-page":"660","article-title":"Barrett's oesophagus - radiological features in 100 cases","volume":"78","author":"Brenmer, R.M.; Bremner, C.G.","year":"1990","unstructured":"Brenmer RM, Bremner CG. Barrett's oesophagus - radiological features in 100 cases. S Afr MedJ 1990;78:660-4.","journal-title":"S Afr MedJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0140-6736(94)90349-2","article-title":"Prevalence of metaplasia at the gastro-oesohageal junction","volume":"344","author":"Spechler, S.J.; Zeroogian, J.M.; Antonioli, D.A.; Wang, H.H.; Goyal, R.K.","year":"1994","unstructured":"Spechler SJ, Zeroogian JM, Antonioli DA, Wang HH, Goyal RK. Prevalence of metaplasia at the gastro-oesohageal junction. Lancet 1994;344: 1533-6.","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/1097-0142(19920101)69:1<8::AID-CNCR2820690105>3.0.CO;2-Q","article-title":"A comparative cytopathologic and histologic study of atypia, dysplasia, and adenocarcinoma in Barrett's esophagus","volume":"69","author":"Geisinger, K.R.; Teot, L.A.; Richter, J.E.","year":"1992","unstructured":"Geisinger KR, Teot LA, Richter JE. A comparative cytopathologic and histologic study of atypia, dysplasia, and adenocarcinoma in Barrett's esophagus. Cancer 1992;69:8-16.","journal-title":"Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/dote\/7.2.131","article-title":"Fibreoptic measurement of alkaline gastro esophageal reflux: technical aspects and clinical indications","volume":"7","author":"Becchi, P.","year":"1994","unstructured":"Becchi P. Fibreoptic measurement of alkaline gastro esophageal reflux: technical aspects and clinical indications. Dis Esophagus 1994;7:131-8.","journal-title":"Dis Esophagus"},{"key":"ref_32","first-page":"702","article-title":"Superficial esophageal carcinoma: evaluation by endoscopic ultrasonography","volume":"89","author":"Yoshikane, H.; Tsukamoto, Y.; Niwa, Y.","year":"1994","unstructured":"Yoshikane H, Tsukamoto Y, Niwa Y, et al. Superficial esophageal carcinoma: evaluation by endoscopic ultrasonography. Am J Gastroenterol 1994;89:702-7.","journal-title":"Am J Gastroenterol"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/dote\/9.4.247","article-title":"Nissen fundoplication for gastroesophageal reflux disease: How does Nissen fundoplication prevent reflux?","volume":"9","author":"Little, A.G.","year":"1996","unstructured":"Little AG. Nissen fundoplication for gastroesophageal reflux disease: How does Nissen fundoplication prevent reflux? Diseases of the Esophagus 1996;9:247-50.","journal-title":"Diseases of the Esophagus"},{"key":"ref_34","first-page":"9","article-title":"Nissen fundoplication for gastro-esophageal reflux disease. Evaluation of primary repair in 100 consecutive patients","volume":"204","author":"DeMeester, T.R.; Bonavina, L.; Albertucci, M.","year":"1986","unstructured":"DeMeester TR, Bonavina L, Albertucci M. Nissen fundoplication for gastro-esophageal reflux disease. Evaluation of primary repair in 100 consecutive patients. Ann Surg 1986;204:9-20."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/bjs.1800830242","article-title":"Conservative treatment versus antireflux surgery in Barrett's oesophagus: long-term results of a prospective study","volume":"83","author":"Ortiz, A.; Martinez de Haro, L.F.; Parrilla, P.","year":"1996","unstructured":"Ortiz A, Martinez de Haro LF, Parrilla P, et al. Conservative treatment versus antireflux surgery in Barrett's oesophagus: long-term results of a prospective study. BrJ Surg 1996;83:274-8.","journal-title":"BrJ Surg"},{"key":"ref_36","first-page":"554","article-title":"Barrett's oesophagus. Comparison of benign and malignant cases","author":"Skinner, D.B.; Walther, B.C.; Riddell, R.H.; Schmidt, H.; Iascone, C.; De Meester, T.R.","year":"1983","unstructured":"Skinner DB, Walther BC, Riddell RH, Schmidt H, Iascone C, De Meester TR. Barrett's oesophagus. Comparison of benign and malignant cases.Ann Surg 1983;198:554-65.","journal-title":"Ann Surg"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-5223(19)34219-9","article-title":"Endoscopic surveillance of Barrett's esophagus. Does it help ?","volume":"105","author":"JM, Jr, Streitz; CW, Jr, Andrews; FH, Jr, Ellis","year":"1993","unstructured":"Streitz JM Jr, Andrews CW Jr, Ellis FH Jr. Endoscopic surveillance of Barrett's esophagus. Does it help ? J Thorac Cardiovasc Surg 1993;105:383-8.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/1097-0142(19850315)55:6<1353::AID-CNCR2820550632>3.0.CO;2-D","article-title":"Analysis of adenocarcinoma in Barrett's esophagus utilising a staging system","volume":"55","author":"Rosenberg, J.C.; Budev, H.; C, Edwards R.; Singal, S.; Steiger, Z.; Sundareson, A.S.","year":"1985","unstructured":"Rosenberg JC, Budev H, Edwards R C, Singal S, Steiger Z, Sundareson AS. Analysis of adenocarcinoma in Barrett's esophagus utilising a staging system. Cancer 1985;55:1353-60.","journal-title":"Cancer"},{"key":"ref_39","first-page":"331","article-title":"Surgery in Barrett's oesophagus. Eur J3CancerPrev","volume":"1","author":"Spencer, J.","year":"1992","unstructured":"Spencer J. Surgery in Barrett's oesophagus. Eur J3CancerPrev 1992;1:331-5."},{"key":"ref_40","first-page":"302","article-title":"Endoscopic argon beam plasma coagulation in the restoration of squamous lining in Barrett's oesophagus","volume":"29","author":"Byrne, J.P.; R, Armstrong G.; Attwood, S.E.A.","year":"1997","unstructured":"Byrne JP, Armstrong G R, Attwood SEA. Endoscopic argon beam plasma coagulation in the restoration of squamous lining in Barrett's oesophagus. Endoscopy 1997;29:302.","journal-title":"Endoscopy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0140-6736(96)03054-1","article-title":"Eradication of high-grade dysplasia in columnar-lined (Barrett's) oesophagus by photodynamic therapy with endogenously generated protoporphyrin","volume":"348","author":"Barr, H.; Shepherd, N.A.; Dix, A.; Roberts, D.J.; Tan, W.C.; Krasner, N.","year":"1996","unstructured":"Barr H, Shepherd NA, Dix A, Roberts DJ, Tan WC, Krasner N. Eradication of high-grade dysplasia in columnar-lined (Barrett's) oesophagus by photodynamic therapy with endogenously generated protoporphyrin. Lancet 1996;348: 584-5.","journal-title":"Lancet"},{"key":"ref_42","first-page":"1470","article-title":"Early adenocarcinoma in Barrett's oesophagus. BrJ7 Surg","volume":"84","author":"Holscher, A.H.; Bollschweiler, E.; Schneider, P.M.; Siewert, JR","year":"1997","unstructured":"Holscher AH, Bollschweiler E, Schneider PM, Siewert JR. Early adenocarcinoma in Barrett's oesophagus. BrJ7 Surg 1997;84: 1470-3."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/bjc.1995.34","article-title":"E-Cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus","volume":"71","author":"Bongiorno, P.F.; al-Kasspooles, M.; Lee, S.W.","year":"1995","unstructured":"Bongiorno PF, al-Kasspooles M, Lee SW, et al. 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