{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:49:07Z","timestamp":1774979347634,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"879","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The non-Hodgkin's lymphomas (NHL) are a heterogenous group of disorders characterised by malignant proliferation of lymphoid cells. The cellular origin is relatively well established with subtypes corresponding to the various stages of lymphocyte differentiation. The term encompasses a hotchpotch of conditions with very different morphological appearance, behaviour and clinical outcome. NHL comprise 2.4% of all cancers, with incidence increasing with age. The commonest presentation is with progressive lymphadenopathy, though extranodal manifestations are present in a significant proportion. The clinical behaviour ranges from a benign, indolent course to rapidly progressive disease; prognosis varies from weeks to many years. Treatment is correspondingly diverse, from \u2018watchful waiting\u2019 to high-dose chemotherapy with bone marrow stem cell transplantation. Cure is possible in an increasing number of patients and much interest currently lies in identifying patients with high-risk disease necessitating the use of intensive treatment regimens.<\/jats:p>","DOI":"10.1136\/pgmj.75.879.2","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:04:10Z","timestamp":1424217850000},"page":"2-6","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Management of non-Hodgkin's lymphomas"],"prefix":"10.1093","volume":"75","author":[{"given":"P J","family":"Mounter","sequence":"first","affiliation":[{"name":"Department of Haematology, Royal Victoria Infirmary , Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Lennard","sequence":"additional","affiliation":[{"name":"Department of Haematology, Royal Victoria Infirmary , Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"2023042616090760000_B1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1056\/NEJM198701083160204","article-title":"Multiple recurrent genomic defects in follicular lymphoma: a possible model for cancer","volume":"316","author":"Yunis","year":"1987","journal-title":"N Engl J Med"},{"key":"2023042616090760000_B2"},{"issue":"suppl","key":"2023042616090760000_B3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2141.1975.tb00911.x","article-title":"The histopathology of malignant lymphoma","volume":"31","author":"Lennert","year":"1975","journal-title":"Br J Haematol"},{"key":"2023042616090760000_B4"},{"key":"2023042616090760000_B5","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A Revised European-American Classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"2023042616090760000_B6","first-page":"1860","article-title":"Report of the committee on Hodgkin's disease staging","volume":"31","author":"Carbone","year":"1971","journal-title":"Cancer Res"},{"key":"2023042616090760000_B7"},{"key":"2023042616090760000_B8","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1200\/JCO.1986.4.10.1470","article-title":"Follicular lymphomas: prognostic factors for response and survival","volume":"4","author":"Gallagher","year":"1986","journal-title":"J Clin Oncol"},{"key":"2023042616090760000_B9","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/oxfordjournals.annonc.a058044","article-title":"The identification of discrete prognostic groups in low-grade non-Hodgkin's lymphomas. 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