{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T16:08:15Z","timestamp":1704902895506},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"879","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The survival of young patients (\u2a7d 50 years of age) with carcinoma of the oesophagus or stomach has been reported to be poorer than that of their older counterparts. The aim of the current study was to review the outcome of such young patients with oesophagogastric cancer and to compare the outcome in patients with carcinoma of the oesophagus\/cardia with patients with carcinoma of the more distal stomach. The study population was 50 patients. Tumour location was oesophagus\/cardia (n=33) and gastric body\/antrum (n=17). The most common presenting symptoms were weight loss (66%), epigastric pain (54%), dysphagia (50%), and heartburn (40%). Seventeen patients had experienced foregut symptoms for a period of \u2a7e6 months. These patients were more likely to have symptoms of gastro-oesophageal reflux disease and to have received acid suppression therapy than patients with shorter symptom durations. Only 20 patients underwent a potentially curative resection, while 10 underwent open and close laparotomy. The overall median survival was 7 months and the 5-year survival was 8%. Multivariate analysis revealed that surgical resection and UICC stage were the only factors that significantly influenced survival. There was no difference in the survival of patients with proximally situated tumours compared to those with distally located tumours. Wide variations in clinical practice were seen between different surgeons. Consequently, a multidisciplinary team designed to manage all patients with oesophagogastric cancer according to nationally agreed protocols has been established in our hospital. Earlier diagnosis of these tumours is to be encouraged, even if this necessitates the more liberal use of endoscopy in the evaluation of young patients with persistent foregut symptoms.<\/jats:p>","DOI":"10.1136\/pgmj.75.879.22","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:04:10Z","timestamp":1424217850000},"page":"22-26","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Outcome of oesophagogastric carcinoma in young patients"],"prefix":"10.1093","volume":"75","author":[{"given":"D J","family":"Bowrey","sequence":"first","affiliation":[{"name":"University Department of Surgery, University Hospital of Wales , Heath Park, Cardiff, CF4 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G W B","family":"Clark","sequence":"additional","affiliation":[{"name":"University Department of Surgery, University Hospital of Wales , Heath Park, Cardiff, CF4 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B I","family":"Rees","sequence":"additional","affiliation":[{"name":"University Department of Surgery, University Hospital of Wales , Heath Park, Cardiff, CF4 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G T","family":"Williams","sequence":"additional","affiliation":[{"name":"University Department of Surgery, University Hospital of Wales , Heath Park, Cardiff, CF4 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P D","family":"Carey","sequence":"additional","affiliation":[{"name":"University Department of Surgery, University Hospital of Wales , Heath Park, Cardiff, CF4 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"2023042616091302500_B1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/bjc.1990.314","article-title":"Increasing incidence of adenocarcinoma of the gastric cardia and adjacent sites","volume":"62","author":"Powell","year":"1990","journal-title":"Br J Cancer"},{"key":"2023042616091302500_B2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1001\/jama.1991.03460100089030","article-title":"Rising incidence of adenocarcinoma of the esophagus and gastric cardia","volume":"265","author":"Blot","year":"1991","journal-title":"JAMA"},{"key":"2023042616091302500_B3","volume-title":"Cancer Statistics Registrations 1970\u20131990","author":"Office for National Statistics (formerly Office of Population Censuses and Surveys)","year":"1990"},{"key":"2023042616091302500_B4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF01658407","article-title":"A clinicopathological study of gastric cancer with special reference to age of the patients: an analysis of 1630 cases","volume":"13","author":"Mitsudomi","year":"1989","journal-title":"World J Surg"},{"key":"2023042616091302500_B5","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/bjc.1991.220","article-title":"Lower survival rate for patients under 30 years of age and surgically treated for gastric carcinoma","volume":"63","author":"Maehara","year":"1991","journal-title":"Br J Cancer"},{"key":"2023042616091302500_B6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/1097-0142(19940715)74:2<573::AID-CNCR2820740207>3.0.CO;2-K","article-title":"Morphologic features in esophageal squamous cell carcinoma of young adults in North China","volume":"74","author":"Lu","year":"1994","journal-title":"Cancer"},{"key":"2023042616091302500_B7","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1002\/1097-0142(19900501)65:9<2086::AID-CNCR2820650933>3.0.CO;2-B","article-title":"A comparison of patterns of metastasis in gastric cancer by histologic type and age","volume":"65","author":"Esaki","year":"1990","journal-title":"Cancer"},{"key":"2023042616091302500_B8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jso.2930520213","article-title":"Relationship between age and the time of surgery and prognosis after gastrectomy for gastric cancer","volume":"52","author":"Moriguchi","year":"1993","journal-title":"J Surg Oncol"},{"key":"2023042616091302500_B9","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1002\/1097-0142(19941101)74:9<2425::AID-CNCR2820740906>3.0.CO;2-1","article-title":"Impact of age and sex on survival after curative resection for carcinoma of the esophagus","volume":"74","author":"Badwe","year":"1994","journal-title":"Cancer"},{"key":"2023042616091302500_B10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/bjc.1992.85","article-title":"Prognosis for surgically treated gastric cancer patients is poorer for women than men in all patients under age 50","volume":"65","author":"Maehara","year":"1992","journal-title":"Br J Cancer"},{"key":"2023042616091302500_B11","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/1097-0142(19850715)56:2<388::AID-CNCR2820560231>3.0.CO;2-J","article-title":"Carcinoma of the stomach in young persons","volume":"56","author":"Grabiec","year":"1985","journal-title":"Cancer"},{"key":"2023042616091302500_B12","volume-title":"Manual for staging cancer","author":"American Joint Committee on Cancer: Stomach cancer","year":"1992","edition":"4th edn"},{"key":"2023042616091302500_B13","volume-title":"Manual for staging cancer","author":"American Joint Committee on Cancer: Esophageal cancer","year":"1992","edition":"4th edn"},{"key":"2023042616091302500_B14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/gut.40.2.192","article-title":"Open access gastroscopy: second survey of current practice in the United Kingdom","volume":"40","author":"Silcock","year":"1997","journal-title":"Gut"},{"key":"2023042616091302500_B15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00007611-197906000-00007","article-title":"Gastric carcinoma in young adults","volume":"72","author":"Bedikian","year":"1979","journal-title":"South Med J"},{"key":"2023042616091302500_B16","first-page":"883","article-title":"Carcinoma of the stomach in the young adult","volume":"150","author":"Bloss","year":"1980","journal-title":"Surg Gynecol Obstet"},{"key":"2023042616091302500_B17","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1002\/1097-0142(19870401)59:7<1362::AID-CNCR2820590722>3.0.CO;2-0","article-title":"Gastric carcinoma in the young","volume":"59","author":"Tso","year":"1987","journal-title":"Cancer"},{"key":"2023042616091302500_B18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00000658-198811000-00008","article-title":"Gastric carcinoma in young adults","volume":"208","author":"Matley","year":"1988","journal-title":"Ann Surg"},{"key":"2023042616091302500_B19","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0003-4975(90)90152-V","article-title":"Esophageal carcinoma in young patients","volume":"49","author":"Mori","year":"1990","journal-title":"Ann Thorac Surg"},{"key":"2023042616091302500_B20","first-page":"371","article-title":"Oesophagogastrectomy for carcinoma in patients under 50 years of age","volume":"41","author":"Adam","year":"1996","journal-title":"J R Coll Surg Edinb"},{"key":"2023042616091302500_B21","volume-title":"A Policy Framework for Commissioning Cancer Services","author":"Expert Advisory Group on Cancer to the Chief Medical Officer of England and Wales","year":"1994"},{"key":"2023042616091302500_B22","first-page":"413","article-title":"A multi-disciplinary approach to the management of oesophago-gastric carcinoma: the early experience (Abstract)","volume":"85","author":"Clark","year":"1998","journal-title":"Br J Surg"},{"key":"2023042616091302500_B23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0960-7404(96)80038-7","article-title":"Carcinoma of the oesophagus: time for a multi-disciplinary approach ?","volume":"5","author":"Clark","year":"1997","journal-title":"Surg Oncol"},{"key":"2023042616091302500_B24"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/75\/879\/22\/50046654\/postgradmedj-75-22.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/75\/879\/22\/50046654\/postgradmedj-75-22.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T16:15:26Z","timestamp":1682525726000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/75\/879\/22\/7044951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,1]]},"references-count":24,"journal-issue":{"issue":"879","published-online":{"date-parts":[[1999,1,1]]},"published-print":{"date-parts":[[1999,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.75.879.22","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1999,1]]},"published":{"date-parts":[[1999,1,1]]}}}