{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:06:37Z","timestamp":1769119597338,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"882","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,4,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Little is known about orthostatic blood pressure regulation in acute stroke. We determined postural haemodynamic responses in 40 patients with acute stroke (mild or moderate severity) and 40 non-stroke control in-patients, at two days (\u2018Day 1\u2019) and one week (\u2018Week 1\u2019) post-admission. Following a 10-minute supine rest and baseline readings, subjects sat up and blood pressure and heart rate were taken for 5 minutes. The procedure was repeated with subjects moving from supine to the standing posture. Haemodynamic changes from supine data were analysed. On standing up, the control group had a transient significant fall in mean arterial blood pressure on Day 1 but not Week 1. No significant changes were seen on either day when sitting up. In contrast to controls, the stroke group showed increases in mean arterial blood pressure on moving from supine to the sitting and standing positions on both days. Persistent postural hypotension defined as \u2a7e20 mmHg systolic fall occurred in &amp;lt;10% of either of the study groups on both days. Sitting and standing heart rates in both groups were significantly faster than supine heart rate on both days. The orthostatic blood pressure elevation is consistent with sympathetic nervous system overactivity which has been reported in acute stroke. Upright positioning as part of early rehabilitation and mobilisation following mild-to-moderate stroke would, therefore, not predispose to detrimental postural reductions in blood pressure.<\/jats:p>","DOI":"10.1136\/pgmj.75.882.213","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:04:10Z","timestamp":1424217850000},"page":"213-218","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Orthostatic haemodynamic responses in acute stroke"],"prefix":"10.1093","volume":"75","author":[{"given":"B","family":"Panayiotou","sequence":"first","affiliation":[{"name":"Elderly Care Department, Manor Hospital , Walsall WS2 9PS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Reid","sequence":"additional","affiliation":[{"name":"Elderly Care Department, Manor Hospital , Walsall WS2 9PS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fotherby","sequence":"additional","affiliation":[{"name":"Elderly Care Department, Manor Hospital , Walsall WS2 9PS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Crome","sequence":"additional","affiliation":[{"name":"Elderly Care Department, Manor Hospital , Walsall WS2 9PS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"2023042616220354300_B1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/01.STR.12.2.200","article-title":"Plasma norepinephrine in stroke","volume":"12","author":"Myers","year":"1981","journal-title":"Stroke"},{"key":"2023042616220354300_B2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/01.STR.25.4.787","article-title":"Cardiovascular autonomic reflexes in brain infarction","volume":"25","author":"Korpelainen","year":"1994","journal-title":"Stroke"},{"key":"2023042616220354300_B3","first-page":"409","article-title":"Twenty-four-hour blood pressure profiles following stroke","volume":"1","author":"Panayiotou","year":"1996","journal-title":"Blood Press Monitor"},{"key":"2023042616220354300_B4","first-page":"11","volume-title":"Syncope in the older patient: causes, investigations, and consequences of syncope and falls.","author":"Kenny","year":"1996"},{"key":"2023042616220354300_B5","first-page":"178","volume-title":"Clinical neurology of ageing.","author":"Meyer","year":"1984"},{"key":"2023042616220354300_B6","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1212\/WNL.39.5.638","article-title":"The Canadian Neurological scale: validation and reliability assessment","volume":"39","author":"Cote","year":"1989","journal-title":"Neurology"},{"key":"2023042616220354300_B7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/BF00812162","article-title":"Was it infarction or haemorrhage? A clinical diagnosis by means of the Allen (\u2018Guy's Hospital') score","volume":"239","author":"Celani","year":"1992","journal-title":"J Neurol"},{"key":"2023042616220354300_B8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/01.STR.20.6.828","article-title":"Interobserver agreement for the assessment of handicap in stroke patients","volume":"6","author":"Bamford","year":"1989","journal-title":"Stroke"},{"key":"2023042616220354300_B9","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1001\/jama.1981.03320190035023","article-title":"Blood pressure after stroke","volume":"246","author":"Wallace","year":"1981","journal-title":"JAMA"},{"key":"2023042616220354300_B10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1212\/WNL.45.5.865","article-title":"Common drugs may influence motor recovery after stroke","volume":"45","author":"Goldstein LB and the Acute Stroke Study Investigators","year":"1995","journal-title":"Neurology"},{"key":"2023042616220354300_B11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00004872-199106000-00016","article-title":"Accuracy of SpaceLabs 90207 determined by the British Hypertension Society protocol","volume":"9","author":"O'Brien","year":"1991","journal-title":"J Hypertens"},{"key":"2023042616220354300_B12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/08037059709062093","article-title":"Orthostatic blood pressure on prolonged standing in elderly hospital in-patients","volume":"6","author":"Fotherby","year":"1997","journal-title":"Blood Press"},{"key":"2023042616220354300_B13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0140-6736(65)92090-8","article-title":"Effect of posture on blood pressure in elderly patients","volume":"1","author":"Johnson","year":"1965","journal-title":"Lancet"},{"key":"2023042616220354300_B14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/j.1552-4604.1994.tb04977.x","article-title":"Haemodynamic response to the upright posture","volume":"34","author":"Smith","year":"1994","journal-title":"J Clin Pharmacol"},{"key":"2023042616220354300_B15","first-page":"308","volume-title":"A textbook of clinical disorders of the autonomic nervous system","author":"Wieling","year":"1988","edition":"2nd"},{"key":"2023042616220354300_B16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0303-8467(88)80008-8","article-title":"Blood pressure and both venous and urinary catecholamines after cerebral infarction","volume":"90","author":"Jansen","year":"1988","journal-title":"Clin Neurol Neurosurg"},{"key":"2023042616220354300_B17","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1161\/01.STR.25.9.1730","article-title":"Changes of circadian blood pressure patterns after haemodynamic and thromboembolic brain infarction","volume":"25","author":"Sander","year":"1994","journal-title":"Stroke"},{"key":"2023042616220354300_B18","first-page":"47","volume-title":"Syncope in the older patient.","author":"Wieling","year":"1996"},{"key":"2023042616220354300_B19","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/01.HYP.21.4.498","article-title":"Age and gender influence muscle sympathetic nerve activity at rest in healthy humans","volume":"21","author":"Ng","year":"1993","journal-title":"Hypertension"},{"key":"2023042616220354300_B20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/geronj\/41.3.319","article-title":"Age differences in plasma norepinephrine kinetics in humans","volume":"41","author":"Veith","year":"1986","journal-title":"J Gerontol"},{"key":"2023042616220354300_B21","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1161\/01.STR.26.10.1811","article-title":"Postprandial and orthostatic cardiovascular changes after acute stroke","volume":"26","author":"Robinson","year":"1995","journal-title":"Stroke"},{"key":"2023042616220354300_B22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/030006059402200202","article-title":"The effect of postprandial hypotension on rehabilitation of the frail elderly with cerebrovascular disease","volume":"22","author":"Farnworth","year":"1994","journal-title":"J Int Med Res"},{"key":"2023042616220354300_B23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1161\/01.STR.27.2.247","article-title":"Reduced heart rate variability after right-sided stroke","volume":"27","author":"Naver","year":"1996","journal-title":"Stroke"},{"key":"2023042616220354300_B24","first-page":"43","article-title":"Studies into postural hypotension in elderly patients","volume":"96","author":"Palmer","year":"1983","journal-title":"NZ Med J"},{"key":"2023042616220354300_B25","first-page":"198","article-title":"Evaluation of orthostatic hypotension using power spectral analysis","volume":"6","author":"Moriguchi","year":"1993","journal-title":"Am J Hypertens"},{"key":"2023042616220354300_B26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.jhh.1000430","article-title":"Antihypertensive therapy and orthostatic responses in elderly hospital inpatients","volume":"11","author":"Fotherby","year":"1997","journal-title":"J Hum Hypertens"},{"key":"2023042616220354300_B27","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1136\/pgmj.70.830.878","article-title":"Orthostatic hypotension and antihypertensive treatment in the elderly","volume":"70","author":"Fotherby","year":"1994","journal-title":"Postgrad Med J"},{"key":"2023042616220354300_B28","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1136\/bmj.308.6945.1674","article-title":"Comparability and validity of two clinical scores in the early differential diagnosis of acute stroke","volume":"308","author":"Celani","year":"1994","journal-title":"BMJ"},{"key":"2023042616220354300_B29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/ageing\/26.suppl_3.P21-c","article-title":"Reduced diurnal blood pressure variation in haemorrhagic stroke","volume":"26 (suppl 3)","author":"Fotherby","year":"1997","journal-title":"Age Ageing"},{"key":"2023042616220354300_B30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00878874","article-title":"Changes of circadian blood pressure patterns and cardiovascular parameters indicate lateralisation of sympathetic activation following hemispheric brain infarction","volume":"242","author":"Sander","year":"1995","journal-title":"J Neurol"},{"key":"2023042616220354300_B31","first-page":"291","volume-title":"A textbook of clinical disorders of the autonomic nervous system","author":"Wieling","year":"1992","edition":"3rd"},{"key":"2023042616220354300_B32","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0002-9343(97)89517-4","article-title":"Reproducibility of orthostatic hypotension in symptomatic elderly","volume":"100","author":"Ward","year":"1996","journal-title":"Am J Med"},{"key":"2023042616220354300_B33","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1001\/jama.1997.03540400049030","article-title":"Patterns of orthostatic blood pressure and their clinical correlates in a frail, elderly population","volume":"277","author":"Ooi","year":"1997","journal-title":"JAMA"},{"key":"2023042616220354300_B34","first-page":"420","volume-title":"Stroke: a practical guide to management.","author":"Warlow","year":"1996"},{"key":"2023042616220354300_B35","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1742-1241.1998.tb11596.x","article-title":"Blood pressure measurement and antihypertensive therapy in acute stroke","volume":"52","author":"Panayiotou","year":"1998","journal-title":"Int J Clin Pract"},{"key":"2023042616220354300_B36","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1172\/JCI112148","article-title":"Prevention of bedrest-induced physical deconditioning by daily dobutamine infusions","volume":"76","author":"Sullivan","year":"1985","journal-title":"J Clin Invest"},{"key":"2023042616220354300_B37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1532-5415.1993.tb05942.x","article-title":"Transcranial Doppler assessment of the cerebral circulation during postprandial hypotension in the elderly","volume":"41","author":"Krajewski","year":"1993","journal-title":"J Am Geriatr Soc"},{"key":"2023042616220354300_B38","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/01.STR.24.9.1376","article-title":"Decrease in cerebral blood flow with blood pressure reductions in patients with chronic stroke","volume":"24","author":"Mori","year":"1993","journal-title":"Stroke"},{"key":"2023042616220354300_B39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1042\/cs0940005","article-title":"Blood pressure in autonomic failure: drinks, meals and other ordeals","volume":"94","author":"Shannon","year":"1998","journal-title":"Clin Sci"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/75\/882\/213\/50046555\/postgradmedj-75-213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/75\/882\/213\/50046555\/postgradmedj-75-213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T06:16:32Z","timestamp":1691302592000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/75\/882\/213\/7044936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4,1]]},"references-count":39,"journal-issue":{"issue":"882","published-online":{"date-parts":[[1999,4,1]]},"published-print":{"date-parts":[[1999,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.75.882.213","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1999,4]]},"published":{"date-parts":[[1999,4,1]]}}}