{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:44:31Z","timestamp":1756385071558},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"883","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Cryptococcal infection uncommonly presents with pulmonary manifestations and even more rarely so as massive bilateral effusions. Pleural involvement is usually associated with underlying pulmonary parenchymal lesions and is unusual while on antifungal therapy. We report a patient with cryptococcal meningitis who, while on intravenous 5-flucytosine and amphotericin B, developed life-threatening bilateral massive pleural effusions with evidence of spontaneous resolution, consistent with prior hypothesis of antigenic stimulation as the cause of pleural involvement.<\/jats:p>","DOI":"10.1136\/pgmj.75.883.297","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:04:10Z","timestamp":1424217850000},"page":"297-298","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Massive pleural effusions in cryptococcal meningitis"],"prefix":"10.1093","volume":"75","author":[{"given":"C M M","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Medicine, University Hospital, Faculty of Medicine, University of Malaya , 50603 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K H","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, Faculty of Medicine, University of Malaya , 50603 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C K","family":"Liam","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, Faculty of Medicine, University of Malaya , 50603 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"2023042616340087800_B1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1001\/jama.1975.03250060035020","article-title":"Cryptococcal pleural effusion","volume":"232","author":"Smilack","year":"1975","journal-title":"JAMA"},{"key":"2023042616340087800_B2","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/0002-9343(68)90190-3","article-title":"Cryptococcosis: current status","volume":"45","author":"Littman","year":"1968","journal-title":"Am J Med"},{"key":"2023042616340087800_B3","first-page":"743","article-title":"Pleural effusions due to Cryptococcus neoformans: a review of the literature and report of two cases with cryptococcal antigen determinations","volume":"121","author":"Young","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"2023042616340087800_B4","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0009-9260(05)83214-3","article-title":"Cryptococcal pneumonia in patients with the acquired immunodeficiency syndrome","volume":"50","author":"Friedman","year":"1995","journal-title":"Clin Radiol"},{"key":"2023042616340087800_B5","first-page":"334","article-title":"An autopsied case of pleuro-pulmonary cryptococcosis","volume":"32","author":"Suzuki","year":"1994","journal-title":"Nippon Kyobu Shikkan Gakkai Zasshi"},{"key":"2023042616340087800_B6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1378\/chest.91.3.459","article-title":"Pleural cryptococcosis in the acquired immune deficiency syndrome","volume":"91","author":"Newman","year":"1987","journal-title":"Chest"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article\/75\/883\/297\/7044929","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article\/75\/883\/297\/7044929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T16:35:35Z","timestamp":1682526935000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/75\/883\/297\/7044929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5,1]]},"references-count":6,"journal-issue":{"issue":"883","published-online":{"date-parts":[[1999,5,1]]},"published-print":{"date-parts":[[1999,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.75.883.297","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1999,5]]},"published":{"date-parts":[[1999,5,1]]}}}