{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:44:12Z","timestamp":1772196252802,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"892","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A total of 87 patients (17 female, 70 male) were admitted to Siriraj Hospital, Mahidol University, Bangkok, Thailand, from January 1996 to December 1997, with a diagnosis of cryptococcal meningitis and underlying AIDS. The age range was 14\u201370 years, mean 32.1. Six females (35%) and thirty-one males (44%) died, while the others were discharged home after clinical improvement. The mean duration of admission of those who died was 14.5 days, which was shorter than that of the patients who survived (25.7 days). Cerebral cryptococcosis was diagnosed using culture (100%), India ink preparation (91%), latex agglutination test (100%), and polymerase chain reaction (86%). Polymerase chain reaction fingerprinting of Cryptococcus neoformans revealed 99% serotype A and 1% serotype B. The mean minimum inhibitory concentrations of amphotericin B, flucytosine, fluconazole and itraconazole against 87 isolates of C neoformans were 0.55 \u03bcg\/ml (0.25\u20131, SD = 0.22), 9.5 \u03bcg\/ml (2\u201320, SD = 4.91), 6.9 \u03bcg\/ml (1\u201316, SD = 4.42) and 0.36 \u03bcg\/ml (0.125\u20131.0, SD = 0.23), respectively. These findings showed that the cryptococcal infections were sensitive to these antifungal agents.<\/jats:p>","DOI":"10.1136\/pmj.76.892.85","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:40:22Z","timestamp":1027766422000},"page":"85-88","source":"Crossref","is-referenced-by-count":38,"title":["Cryptococcosis in AIDS"],"prefix":"10.1093","volume":"76","author":[{"given":"P","family":"Imwidthaya","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University , Bangkok 10700, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Poungvarin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University , Bangkok 10700, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,2,1]]},"reference":[{"key":"2023042614000439600_B1","first-page":"542","volume-title":"Medical mycology. 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Clinical and environmental isolates of Cryptococcus neoformans in Bangkok (Thailand).","volume":"108","author":"Imwidthaya","year":"1989","journal-title":"Mycopathologia"},{"key":"2023042614000439600_B13","first-page":"454","article-title":"Latex agglutination test for diagnosing cryptococcosis.","volume":"74","author":"Imwidthaya","year":"1991","journal-title":"J Med Assoc Thai"},{"key":"2023042614000439600_B14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1439-0507.1997.tb00256.x","article-title":"Isolation of specific DNA probes for detection of Cryptococcus neoformans.","volume":"40","author":"Wu","year":"1997","journal-title":"Mycoses"},{"key":"2023042614000439600_B15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0035-9203(97)90391-6","article-title":"Visual loss in immunocompetent patients with Cryptococcus neoformans var gattii meningitis.","volume":"91","author":"Seaton","year":"1997","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2023042614000439600_B16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1439-0507.1997.tb00235.x","article-title":"Prevalence of serotype D in Cryptococcus neoformans isolates from HIV positive and HIVnegative patients in Italy.","volume":"40","author":"Tortorano","year":"1997","journal-title":"Mycoses"},{"key":"2023042614000439600_B17","first-page":"1145","article-title":"Cryptococcus neoformans in Siriraj Hospital 1994\u20131995.","volume":"49","author":"Imwidthaya","year":"1997","journal-title":"Siriraj Hosp Gaz"},{"key":"2023042614000439600_B18","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1023\/A:1007376917836","article-title":"Serotyping of Cryptococcus neoformans strains isolated from clinical specimens in Thailand and their susceptibility to various antifungal agents.","volume":"13","author":"Poonwan","year":"1997","journal-title":"Eur J Epidemiol"},{"key":"2023042614000439600_B19","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1128\/jcm.31.5.1370-1372.1993","article-title":"Two-site comparison of broth microdilution and semisolid agar dilution methods for susceptibility testing of Cryptococus neoformans in three media.","volume":"31","author":"Anaissie","year":"1993","journal-title":"J Clin Microbiol"},{"key":"2023042614000439600_B20","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1128\/jcm.32.10.2494-2500.1994","article-title":"Comparative study of broth macrodilution and microdilution techniques for in vitro antifungal susceptibility testing of yeast by using the national committee for clinical laboratory standards' proposed standard.","volume":"33","author":"Barchiesi","year":"1994","journal-title":"J Clin Microbiol"},{"key":"2023042614000439600_B21","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1128\/AAC.39.11.2459","article-title":"In vitro determination of optimal antifungal combinations against Cryptococcus neoformans and Candida albicans.","volume":"39","author":"Ghannoum","year":"1995","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/76\/892\/85\/50043923\/postgradmedj-76-85.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/76\/892\/85\/50043923\/postgradmedj-76-85.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T14:27:01Z","timestamp":1682519221000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/76\/892\/85\/7039805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2,1]]},"references-count":21,"journal-issue":{"issue":"892","published-online":{"date-parts":[[2000,2,1]]},"published-print":{"date-parts":[[2000,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pmj.76.892.85","relation":{},"ISSN":["1469-0756","0032-5473"],"issn-type":[{"value":"1469-0756","type":"electronic"},{"value":"0032-5473","type":"print"}],"subject":[],"published-other":{"date-parts":[[2000,2]]},"published":{"date-parts":[[2000,2,1]]}}}