{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:25:25Z","timestamp":1765293925800},"reference-count":113,"publisher":"Oxford University Press (OUP)","issue":"894","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary biliary cirrhosis (PBC) is a chronic autoimmune disease characterised by cholestatic liver function tests, antimitochondrial antibodies, and abnormal liver histology. Early descriptions of a rare rapidly progressive disease no longer reflect the more indolent progress often seen today. Many patients have significant long term morbidity through symptoms such as fatigue and itch with a minority progressing to liver failure and need for transplantation. The current data on the diagnosis, clinical progression, and treatment of PBC are reviewed.<\/jats:p>","DOI":"10.1136\/pmj.76.894.199","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:38:40Z","timestamp":1027766320000},"page":"199-206","source":"Crossref","is-referenced-by-count":26,"title":["Primary biliary cirrhosis: new perspectives in diagnosis and treatment"],"prefix":"10.1093","volume":"76","author":[{"given":"Martin I","family":"Prince","sequence":"first","affiliation":[{"name":"Centre for Liver Research, University of Newcastle , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E J","family":"Jones","sequence":"additional","affiliation":[{"name":"Centre for Liver Research, University of Newcastle , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"2023042614100966400_B1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00005792-195012000-00002","article-title":"Primary biliary cirrhosis.","volume":"29","author":"Ahrens","year":"1950","journal-title":"Medicine"},{"key":"2023042614100966400_B2","first-page":"268","article-title":"On a certain affliction of the skin\u2014vitiligoides\u2014a planus tuberosa.","volume":"7","author":"Addison","year":"1857","journal-title":"Guys Hospital Review"},{"key":"2023042614100966400_B3","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM197309272891306","article-title":"The presentation and diagnosis of 100 patients with primary biliary cirrhosis.","volume":"289","author":"Sherlock","year":"1973","journal-title":"N Engl J Med"},{"key":"2023042614100966400_B4","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0140-6736(65)91372-3","article-title":"Serological tests in diagnosis of primary biliary cirrhosis.","volume":"i","author":"Walker","year":"1965","journal-title":"Lancet"},{"key":"2023042614100966400_B5","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1080\/00365521.1984.12005842","article-title":"The prevalence and clinical spectrum of primary biliary cirrhosis in a defined population.","volume":"19","author":"Eriksson","year":"1984","journal-title":"Scand J Gastroenterol"},{"key":"2023042614100966400_B6","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0016-5085(80)90571-5","article-title":"Clinical pattern and course of disease in primary biliary cirrhosis based on an analysis of 236 patients.","volume":"78","author":"Christensen","year":"1980","journal-title":"Gastroenterology"},{"key":"2023042614100966400_B7","first-page":"1278","article-title":"Primary biliary cirrhosis\u2014a revised clinical spectrum.","volume":"i","author":"James","year":"1981","journal-title":"Lancet"},{"key":"2023042614100966400_B8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/hep.1840120116","article-title":"The demography of primary biliary cirrhosis in Ontario, Canada.","volume":"12","author":"Witt-Sullivan","year":"1990","journal-title":"Hepatology"},{"key":"2023042614100966400_B9","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1177\/003591576706001205","article-title":"Primary biliary cirrhosis.","volume":"40","author":"Scheuer","year":"1967","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"2023042614100966400_B10","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJM198702263160907","article-title":"Primary biliary cirrhosis.","volume":"316","author":"Kaplan","year":"1987","journal-title":"N Engl J Med"},{"key":"2023042614100966400_B11","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/hep.510250507","article-title":"Comparison of the clinical features and clinical course of antimitochondrial antibody-positive and negative primary biliary cirrhosis.","volume":"25","author":"Invernizzi","year":"1997","journal-title":"Hepatology"},{"key":"2023042614100966400_B12","first-page":"247","article-title":"Antimitochondrial antibody-negative primary biliary cirrhosis.","volume":"90","author":"Lacerda","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2023042614100966400_B13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/hep.510270303","article-title":"Characterization of antimitochondrial antibodies in health adults.","volume":"27","author":"Mattalia","year":"1998","journal-title":"Hepatology"},{"key":"2023042614100966400_B14","first-page":"124","article-title":"A study of antimitochondrial antibodies in a random population in Estonia.","volume":"92","author":"Turchany","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2023042614100966400_B15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.126.2.277","article-title":"Mitochondrial antibodies in primary biliary cirrhosis. 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