{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T15:10:14Z","timestamp":1682521814407},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"894","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 42 year old man presented with gluten-responsive coeliac disease and secondary pancreatic insufficiency. Subsequently his symptoms relapsed and repeat small intestinal biopsy showed villous atrophy and infiltration by leukaemic cells, despite continuation of a gluten-free diet. Serious causes of relapse and non-responsiveness in coeliac disease include enteropathy-associated T-cell lymphoma, ulcerative jejunitis and an end-stage hypoplastic mucosa. This is the first report of non-responsiveness due to infiltration by leukaemia.<\/jats:p>","DOI":"10.1136\/pmj.76.894.227","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:40:22Z","timestamp":1027766422000},"page":"227-229","source":"Crossref","is-referenced-by-count":0,"title":["A new cause of 'non-responsiveness' in coeliac disease?"],"prefix":"10.1093","volume":"76","author":[{"given":"J S R","family":"Jennings","sequence":"first","affiliation":[{"name":"St James's University Hospital, Division of Medicine , Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J I","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Department of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P D","family":"Howdle","sequence":"additional","affiliation":[{"name":"St James's University Hospital, Division of Medicine , Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"2023042614101394100_B1","first-page":"49","volume-title":"Marsh MN, ed, Coeliac disease.","author":"Howdle","year":"1992"},{"key":"2023042614101394100_B2","first-page":"129","volume-title":"Dobrillo G, Bardhan KD, Stiel A, eds, Non-responders in gastroenterology.","author":"Howdle","year":"1991"},{"key":"2023042614101394100_B3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1046\/j.1365-2036.1996.66237000.x","article-title":"Management of patients with non-responsive coeliac disease.","volume":"10","author":"O'Mahony","year":"1996","journal-title":"Aliment Pharmacol Therapeut"},{"key":"2023042614101394100_B4","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1053\/gast.1997.v112.pm9178673","article-title":"The prevalence and causes of chronic diarrhoea in patients with coeliac sprue treated with a gluten-free diet.","volume":"112","author":"Fine","year":"1997","journal-title":"Gastroenterology"},{"key":"2023042614101394100_B5","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1053\/gast.1997.v112.agast972146","article-title":"Persistence of diarrhoea in treated coeliac sprue: refractory disease or another organ's malfunction?","volume":"112","author":"Gray","year":"1997","journal-title":"Gastroenterology"},{"key":"2023042614101394100_B6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0016-5085(92)91819-P","article-title":"Gluten, major histocompatibility complex and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten-sensitivity (\u2018celiac sprue\u2019).","volume":"102","author":"Marsh","year":"1992","journal-title":"Gastroenterology"},{"key":"2023042614101394100_B7","first-page":"17","volume-title":"Hekkens WTJM, Pena AS, eds, Coeliac disease.","author":"Booth","year":"1974"},{"key":"2023042614101394100_B8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0950-3528(95)90037-3","article-title":"Coeliac disease research and clinical practice: maintaining momentum into the twenty first century.","volume":"9","author":"Ferguson","year":"1995","journal-title":"Bailliere's Clin Gastroenterol"},{"key":"2023042614101394100_B9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/adc.65.8.909","article-title":"Revised criteria for the diagnosis of coeliac disease.","volume":"65","author":"Walker-Smith","year":"1990","journal-title":"Arch Dis Child"},{"key":"2023042614101394100_B10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/jcp.15.4.305","article-title":"Leukaemic lesions of the gastrointestinal tract.","volume":"15","author":"Cornes","year":"1962","journal-title":"J Clin Pathol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/76\/894\/227\/50044154\/postgradmedj-76-227.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/76\/894\/227\/50044154\/postgradmedj-76-227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T14:39:51Z","timestamp":1682519991000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/76\/894\/227\/7040104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4,1]]},"references-count":10,"journal-issue":{"issue":"894","published-online":{"date-parts":[[2000,4,1]]},"published-print":{"date-parts":[[2000,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pmj.76.894.227","relation":{},"ISSN":["1469-0756","0032-5473"],"issn-type":[{"value":"1469-0756","type":"electronic"},{"value":"0032-5473","type":"print"}],"subject":[],"published-other":{"date-parts":[[2000,4]]},"published":{"date-parts":[[2000,4,1]]}}}