{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:44:57Z","timestamp":1761518697346},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"894","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 21 year old woman presenting with galactorrhoea, hyperprolactinaemia, and a pituitary mass on magnetic resonance imaging (MRI) is described who was referred to us before planned pituitary surgery. Although a thorough history did not suggest hypothyroidism, laboratory studies revealed profound primary hypothyroidism. At that time, pituitary MRI showed homogeneous enlargement of the pituitary gland consistent with pituitary hyperplasia due to primary hypothyroidism. With thyroid hormone replacement therapy the galactorrhoea resolved, concentrations of prolactin and thyroid hormones returned to normal, and the pituitary shrunk to normal size within two months. This case illustrates that primary hypothyroidism can present only with galactorrhoea and pituitary mass, and should therefore be considered in the differential diagnosis of hyperprolactinaemia and pituitary enlargement.<\/jats:p>","DOI":"10.1136\/pmj.76.894.232","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:38:40Z","timestamp":1027766320000},"page":"232-234","source":"Crossref","is-referenced-by-count":6,"title":["Galactorrhoea and pituitary mass: a typical prolactinoma?"],"prefix":"10.1093","volume":"76","author":[{"given":"Michael","family":"Br\u00e4ndle","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital Z\u00fcrich , 8091 Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schmid","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital Z\u00fcrich , 8091 Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"2023042614100481200_B1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(97)80050-5","article-title":"Hypothyroidism.","volume":"349","author":"Lindsay","year":"1997","journal-title":"Lancet"},{"key":"2023042614100481200_B2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1136\/bmj.3.5772.462","article-title":"Amenorrhoea, galactorrhoea, and primary hypothyroidism with high circulating levels of prolactin.","volume":"iii","author":"Edwards","year":"1971","journal-title":"BMJ"},{"key":"2023042614100481200_B3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00007611-198609000-00041","article-title":"Amenorrhea-galactorrhea due to occult hypothyroidism.","volume":"79","author":"Levine","year":"1986","journal-title":"South Med J"},{"key":"2023042614100481200_B4","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/0002-9343(78)90517-X","article-title":"Serum prolactin levels in untreated primary hypothyroidism.","volume":"64","author":"Honbo","year":"1978","journal-title":"Am J Med"},{"key":"2023042614100481200_B5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0889-8529(18)30193-2","article-title":"Pathologic hyperprolactinemia.","volume":"21","author":"Molitch","year":"1992","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2023042614100481200_B6","first-page":"506","article-title":"Hyperprolactinemia and contraception: a prospective study.","volume":"65","author":"Luciano","year":"1985","journal-title":"Obstet Gynecol"},{"key":"2023042614100481200_B7","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0140-6736(69)90938-6","article-title":"Amenorrhoea and galactorrhoea associated with hypothyroidism.","volume":"ii","author":"Bayliss","year":"1969","journal-title":"Lancet"},{"key":"2023042614100481200_B8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF00593219","article-title":"MRI of pituitary hyperplasia in hypothyroidism.","volume":"38","author":"Wolansky","year":"1996","journal-title":"Neuroradiology"},{"key":"2023042614100481200_B9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/BF03351025","article-title":"Pituitary thyrotroph hyperplasia mimicking prolactin-secreting adenoma.","volume":"7","author":"Khalil","year":"1984","journal-title":"J Endocrinol Invest"},{"key":"2023042614100481200_B10","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1210\/jcem.82.3.3796","article-title":"MRI-demonstrable regression of a pituitary mass in a case of primary hypothyroidism after a week of acute thyroid hormone therapy.","volume":"82","author":"Sarlis","year":"1997","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Postgraduate Medical 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