{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:29:06Z","timestamp":1789810146845,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"911","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The phenomenon of calciphylaxis is rare, but potentially fatal. It has been recognised for a long time in patients with chronic renal failure with secondary hyperparathyroidism. Disturbed calcium and phosphate metabolism can result in painful necrosis of skin, subcutaneous tissue and acral gangrene. Appearance of the lesions is distinctive but the pathogenesis remains uncertain. The beneficial effects of parathyroidectomy are controversial. However, correction of hyperphosphataemia or occasionally hypercalcaemia is imperative. Fulminant sepsis as a consequence of secondary infection of necrotic and gangrenous tissue is a frequent cause of patient morbidity and mortality.<\/jats:p>","DOI":"10.1136\/pmj.77.911.557","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:37:40Z","timestamp":1027766260000},"page":"557-561","source":"Crossref","is-referenced-by-count":48,"title":["Calciphylaxis"],"prefix":"10.1093","volume":"77","author":[{"given":"R V","family":"Mathur","sequence":"first","affiliation":[{"name":"Sheffield Kidney Institute, Northern General Hospital , Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Shortland","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northern General Hospital , Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"El Nahas","sequence":"additional","affiliation":[{"name":"Sheffield Kidney Institute, Northern General Hospital , Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"2023042613284284500_B1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/archinte.1976.03630110043012","article-title":"Calciphylaxis in man.","volume":"136","author":"Gipstein","year":"1976","journal-title":"Arch Intern Med"},{"key":"2023042613284284500_B2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/0272-6386(95)90116-7","article-title":"Calciphylaxis presenting with calf pain and plaques in four continuous ambulatory peritoneal dialysis patients and in one pre-dialysis patient.","volume":"25,3","author":"Fine","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"2023042613284284500_B3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.7326\/0003-4819-71-1-129","article-title":"Ischemic ulceration of skin and necrosis of muscle in azotemic hyperparathyroidism.","volume":"71","author":"Richardson","year":"1969","journal-title":"Ann Intern Med"},{"key":"2023042613284284500_B4","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1001\/archinte.1990.00390170018005","article-title":"Calciphylaxis and systemic calcinosis. 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Another basis for livedo-like skin changes.","volume":"20","author":"Chapman","year":"1995","journal-title":"Clin Exp Dermatol"},{"key":"2023042613284284500_B13","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1053\/ajkd.1998.v32.pm9740172","article-title":"Calcific uraemic arteriolopathy (calciphylaxis): an evolving entity?","volume":"32","author":"Llach","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"2023042613284284500_B14","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1046\/j.1523-1755.1999.07316.x","article-title":"Hyperphosphataemia in end-stage renal disease patients: pathophysiological consequences.","volume":"56 (suppl 73)","author":"Llach","year":"1999","journal-title":"Kidney Int"},{"key":"2023042613284284500_B15","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/archinte.1976.03630060064013","article-title":"Dermal necrosis due to thrombosis in severe secondary 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