{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:27:39Z","timestamp":1790501259664,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"911","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignancy associated primary thiamine deficiency has been documented in several experimental tumours, sporadic clinical case reports, and in a number of patients with fast growing haematological malignancies.<\/jats:p>\n               <jats:p>Thiamine status was assessed prospectively in 14 untreated B-chronic lymphocytic leukaemia (CLL) patients, and in 14 age matched control patients with non-malignant disease. Patients with any known cause of absolute, relative, or functional thiamine deficiency were excluded.<\/jats:p>\n               <jats:p>High (&amp;gt;15%) thiamine pyrophosphate effect (TPPE), indicating thiamine deficiency, was found in five out of 14 CLL patients (35.7%) and in none of the controls (p=0.057). Mean (SD) TPPE in the thiamine deficient patients group was 21.6 (3.4)%. In all the patients, thiamine deficiency was subclinical. No correlates for the thiamine deficiency have been found save for an increment of more than 20% in the total leucocyte count over the preceding three months, which was found in all five thiamine deficient patients compared with only one of the nine non-thiamine deficient CLL patients.<\/jats:p>\n               <jats:p>Thus, CLL patients may be prone to develop primary thiamine deficiency possibly promoted by the increased leucocytes span, which may increase thiamine consumption. Since even subclinical thiamine deficiency may be detrimental to the patient's clinical course, and in view of the theoretical danger of thiamine promoted tumour cell proliferation, further large scale studies are warranted to confirm this observation, and to elucidate the issue of thiamine supplementation to CLL patients.<\/jats:p>","DOI":"10.1136\/pmj.77.911.582","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:37:40Z","timestamp":1027766260000},"page":"582-585","source":"Crossref","is-referenced-by-count":36,"title":["Thiamine deficiency in patients with B-chronic lymphocytic leukaemia: a pilot study"],"prefix":"10.1093","volume":"77","author":[{"given":"H","family":"Seligmann","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Unit, Bnai Zion Medical Center, Technion Faculty of Medicine , Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical School , Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Konijn","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical School , Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Prokocimer","sequence":"additional","affiliation":[{"name":"Hematology Division, Beilinson Campus, Rabin Medical Centre, Petach-Tiqva, Sackler School of Medicine , Tel-Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"2023042613282794900_B1","first-page":"270","article-title":"Thiamine.","volume":"63","author":"Finglas","year":"1993","journal-title":"Int J Vitam Nutr Res"},{"key":"2023042613282794900_B2","first-page":"607","article-title":"Vitamins.","volume-title":"Clinical chemistry: principles, procedures, correlations.","author":"Miller","year":"1996"},{"key":"2023042613282794900_B3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/01635588509513832","article-title":"Turnover of [c] thiamine and activities of thiamine pyrophosphate dependent enzymes in tissues of mice with Ehrlich ascites carcinoma.","volume":"6","author":"Trebukhina","year":"1985","journal-title":"Nutr Cancer"},{"key":"2023042613282794900_B4","first-page":"527","article-title":"Glucose and acetate utilization by hyperplastic alveolar nodule outgrowth and adenocarcinoma 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Reuck","year":"1980","journal-title":"Arch Neurol"},{"key":"2023042613282794900_B12","first-page":"134","article-title":"Wernicke's encephalopathy in a child with acute lymphoblastic leukemia treated with polychemotherapy.","volume":"10","author":"Bruck","year":"1991","journal-title":"Clin Neuropathol"},{"key":"2023042613282794900_B13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0090-8258(90)90127-7","article-title":"5-Fluorouracil neurotoxicity.","volume":"36","author":"Moore","year":"1990","journal-title":"Gynecol Oncol"},{"key":"2023042613282794900_B14","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/1097-0142(19920401)69:7<1710::AID-CNCR2820690711>3.0.CO;2-D","article-title":"Thiamine deficiency in hematologic malignant tumors.","volume":"69","author":"Van Zaanen","year":"1992","journal-title":"Cancer"},{"key":"2023042613282794900_B15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ajh.2830290307","article-title":"Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group.","volume":"29","author":"Cheson","year":"1988","journal-title":"Am J Hematol"},{"key":"2023042613282794900_B16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","article-title":"Clinical staging of chronic lymphatic leukemia.","volume":"46","author":"Rai","year":"1975","journal-title":"Blood"},{"key":"2023042613282794900_B17","first-page":"407","article-title":"Functional evaluation of nutritional status: thiamine.","volume-title":"Newer methods of nutrition biochemistry.","author":"Brin","year":"1967"},{"key":"2023042613282794900_B18","first-page":"236","article-title":"Laboratory tests for the assessment of nutritional status.","volume":"4","author":"Sauberlich","year":"1973","journal-title":"Crit Rev Clin Lab Sci"},{"key":"2023042613282794900_B19","first-page":"295","article-title":"In vitro and in vivo stimulation of 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