{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:38:48Z","timestamp":1791610728234,"version":"4.3.4"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"916","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of childhood and early adolescence. It is caused by persistent defective measles virus. Brain biopsies or postmortem histopathological examination show evidence of astrogliosis, neuronal loss, degeneration of dendrites, demyelination, neurofibrillary tangles, and infiltration of inflammatory cells. Patients usually have behavioral changes, myoclonus, dementia, visual disturbances, and pyramidal and extrapyramidal signs. The disease has a gradual progressive course leading to death within 1-3 years. The diagnosis is based upon characteristic clinical manifestations, the presence of characteristic periodic EEG discharges, and demonstration of raised antibody titre against measles in the plasma and cerebrospinal fluid. Treatment for SSPE is still undetermined. A combination of oral isoprinosine (Inosiplex) and intraventricular interferon alfa appears to be the best effective treatment. Patients responding to treatment need to receive it life long. Effective immunisation against measles is the only solution presently available to the problem of this dreaded disease.<\/jats:p>","DOI":"10.1136\/pmj.78.916.63","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:29:07Z","timestamp":1027765747000},"page":"63-70","source":"Crossref","is-referenced-by-count":199,"title":["Subacute sclerosing panencephalitis"],"prefix":"10.1093","volume":"78","author":[{"given":"R K","family":"Garg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,2,1]]},"reference":[{"key":"2023042416150667300_R1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/brain\/73.2.141","article-title":"Encephalitis and encephalomyelitis in England and Wales during last decade","volume":"73","author":"Greenfield","year":"1950","journal-title":"Brain"},{"key":"2023042416150667300_R2","first-page":"7","article-title":"Cellular inclusions in cerebral lesions of epidemic encephalitis","volume":"9","author":"Dawson","year":"1933","journal-title":"Am J Pathol"},{"key":"2023042416150667300_R3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01798371","article-title":"Uber einheimische panencephalomyelitis vom charakter der encephalitis Japonica","volume":"149","author":"Pette","year":"1939","journal-title":"Deutsche Zeitschrift fur Nerven-heilk"},{"key":"2023042416150667300_R4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jnnp.8.3-4.101","article-title":"Une leocoencephalite sclerosante subaigue","volume":"8","author":"Van Bogaert","year":"1945","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2023042416150667300_R5","first-page":"454","article-title":"Sur uncas d\u2019encephalite subaiguea inclusions. Etude anatomoclinique et ultra structurale","volume":"113","author":"Bouteille","year":"1965","journal-title":"Rev Neurol"},{"key":"2023042416150667300_R6","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/221974a0","article-title":"Subacute sclerosing panencephalitis: isolation of measles virus from a brain biopsy","volume":"221","author":"Horta-Barbosa","year":"1969","journal-title":"Nature"},{"key":"2023042416150667300_R7","first-page":"417","volume-title":"Handbook of clinical neurology","author":"Swoveland","year":"1989"},{"key":"2023042416150667300_R8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jama.1972.03200070051006","article-title":"Epidemiology of subacute sclerosing panencephalitis (SSPE): report of the SSPE registry","volume":"220","author":"Jabbour","year":"1972","journal-title":"JAMA"},{"key":"2023042416150667300_R9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1017\/S0950268800054637","article-title":"High incidence of 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study","volume":"111","author":"Halsey","year":"1980","journal-title":"Am J Epidemiol"},{"key":"2023042416150667300_R13","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/ije\/21.5.998","article-title":"The epidemiology of subacute sclerosing panencephalitis in England and Wales 1970\u20131989","volume":"21","author":"Miller","year":"1992","journal-title":"Int J Epidemiol"},{"key":"2023042416150667300_R14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-0404.1998.tb07377.x","article-title":"Environmental risk factors for subacute sclerosing panencephalitis (SSPE)","volume":"98","author":"Zilber","year":"1998","journal-title":"Acta Neurol Scand"},{"key":"2023042416150667300_R15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0022-3476(79)80829-X","article-title":"Epidemiology of subacute sclerosing panencephalitis","volume":"94","author":"Modlin","year":"1979","journal-title":"J Pediatr"},{"key":"2023042416150667300_R16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/clinids\/6.2.239","article-title":"Risk factors in subacute sclerosing panencephaltis: age-and sex-dependent host reactions or intensive exposure","volume":"6","author":"Aaby","year":"1984","journal-title":"Rev Infect Dis"},{"key":"2023042416150667300_R17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0887-8994(89)90045-3","article-title":"Changing character of subacute sclerosing panencephalitis in the United States","volume":"5","author":"Dyken","year":"1989","journal-title":"Pediatr Neurol"},{"key":"2023042416150667300_R18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/viro.1993.1579","article-title":"Clonal expansion of hypermutated measles virus in a SSPE 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panencephalitis","volume":"48","author":"Caruso","year":"1997","journal-title":"Neurology"},{"key":"2023042416150667300_R50","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0002-9394(14)70179-5","article-title":"subacute sclerosing panencephalitis manifesting as viral retinitis: clinical and histopathologic findings","volume":"123","author":"Park","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"2023042416150667300_R51","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1001\/archneur.1979.00500460044004","article-title":"The variable natural history of subacute sclerosing panencephalitis: a study of 118 cases from the Middle East","volume":"56","author":"Risk","year":"1979","journal-title":"Arch Neurol"},{"key":"2023042416150667300_R52","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/088307380001500411","article-title":"Subacute sclerosing panencephalitis with atypical onset: clinical, computed tomography and magnetic resonance imaging 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antibody synthesis in brain","volume":"37","author":"Reiber","year":"1991","journal-title":"Clin Chem"},{"key":"2023042416150667300_R56","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1749-6632.1994.tb38935.x","article-title":"Immune response in subacute sclerosing panencephalitis","volume":"724","author":"Mehta","year":"1994","journal-title":"Ann N Y Acad Sci"},{"key":"2023042416150667300_R57","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1128\/iai.6.3.248-254.1972","article-title":"Identification of different measles virus specific antibodies in serum and cerebrospinal fluid from patients with subacute sclerosing panencephalitis and multiple sclerosis","volume":"6","author":"Salmi","year":"1972","journal-title":"Infection and Immunity"},{"key":"2023042416150667300_R58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0165-5728(82)90073-X","article-title":"Different virus antibodies in serum and cerebro-spinal fluid of patients suffering 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