{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:10:47Z","timestamp":1773677447158,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"921","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Post-myocardial infarction ventricular septal defect (VSD) complicates \u223c2% of myocardial infarctions. Thrombolytic therapy may accelerate the time from myocardial infarction to VSD formation. The effects of thrombolytic therapy in patients with a post-myocardial infarction VSD were investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Demographic, procedural, and event data were retrospectively analysed in patients transferred to a regional cardiothoracic centre with the diagnosis of post-myocardial infarction VSD over five years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty nine patients were analysed; 15 received thrombolytic therapy: 10 (&amp;lt;12 hours) early and five (\u226512 hours) late. The median time to post-myocardial infarction VSD was shorter with thrombolytic therapy at 1 v 5.5 days (p=0.01). The median time to post-myocardial infarction VSD was shorter with early compared with late thrombolytic therapy at 1 v 6 days (p&amp;lt;0.01). There was no difference between late and no thrombolytic therapy, 5.5 v 6 days. Patients treated with thrombolytic therapy had a trend towards higher mortality at 11\/15 (73%) compared with 5\/14 (36%) (p=0.066). Twenty five (86%) patients had surgery. All four not having surgery died. Surgical survival was 13\/25 (52%) at discharge and six months of follow up. Within the surgical group survival with prior thrombolytic therapy was 4\/25 (25%) and 9\/13 (69%) without (p=0.07).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There appears to be an earlier presentation of post-myocardial infarction VSD when thrombolytic therapy has been used. An early presentation can carry a worse prognosis and may have implications for the identification and treatment of this life threatening complication.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/pmj.78.921.408","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:08:40Z","timestamp":1027897720000},"page":"408-412","source":"Crossref","is-referenced-by-count":20,"title":["Influence of thrombolytic therapy on the patterns of ventricular septal rupture after acute myocardial infarction"],"prefix":"10.1093","volume":"78","author":[{"given":"G R","family":"Rhydwen","sequence":"first","affiliation":[{"name":"Cardiology Unit, Papworth Hospital , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Charman","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Papworth Hospital , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Schofield","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Papworth Hospital , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,7,1]]},"reference":[{"key":"2023042416515984400_R1","first-page":"753","article-title":"ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41,299 cases of suspected acute myocardial infarction. ISIS-3 (Third International Study of Infarct Survival) Collaborative Group [see comments]","volume-title":"Lancet","year":"1992"},{"key":"2023042416515984400_R2","first-page":"349","article-title":"Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group [see comments]","volume-title":"Lancet","year":"1988"},{"key":"2023042416515984400_R3","first-page":"397","article-title":"Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell\u2019Infarto Miocardico (GISSI)","volume-title":"Lancet","year":"1986"},{"key":"2023042416515984400_R4","first-page":"673","article-title":"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. 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