{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:20:39Z","timestamp":1773109239927,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"921","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Angioedema is a recognised side effect of rofecoxib, a cyclo-oxygenase-2 (COX-2) inhibitor. But death resulting from a haemorrhagic pulmonary oedema after its ingestion has not been recorded. The case of a 60 year old man who died from haemorrhagic pulmonary oedema in the presence of angioedema after the ingestion of two doses of 12.5 mg of rofecoxib is reported.<\/jats:p>","DOI":"10.1136\/pmj.78.921.439","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:08:40Z","timestamp":1027897720000},"page":"439-440","source":"Crossref","is-referenced-by-count":10,"title":["Fatal haemorrhagic pulmonary oedema and associated angioedema after the ingestion of rofecoxib"],"prefix":"10.1093","volume":"78","author":[{"given":"N P","family":"Kumar","sequence":"first","affiliation":[{"name":"General and Geriatric Medicine, King\u2019s Mill Hospital, Sutton in Ashfield , Nottinghamshire , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Wild","sequence":"additional","affiliation":[{"name":"Protein Reference Unit, Northern General Hospital , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"General and Geriatric Medicine, King\u2019s Mill Hospital, Sutton in Ashfield , Nottinghamshire , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Snape","sequence":"additional","affiliation":[{"name":"General and Geriatric Medicine, King\u2019s Mill Hospital, Sutton in Ashfield , Nottinghamshire , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,7,1]]},"reference":[{"key":"2023042416515417200_R1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/rheumatology\/38.8.779","article-title":"Interpreting the clinical significance of the differential inhibition of cyclo-oxygenase 1 and cyclo-oxygenase 2","volume":"38","author":"Brooks","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"2023042416515417200_R2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/1529-0131(200001)43:1<4::AID-ANR2>3.0.CO;2-V","article-title":"Basic biology and clinical application of specific cyclo-oxygenase-2 inhibitors","volume":"43","author":"Crofford","year":"2000","journal-title":"Arthritis Rheum"},{"key":"2023042416515417200_R3","first-page":"13","article-title":"Focus: rofecoxib (Vioxx)","volume":"26","author":"Committee on Safety of Medicines\/Medicine Control Agency","year":"2000","journal-title":"Current Problems in Pharmacovigilance"},{"key":"2023042416515417200_R4","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1056\/NEJM200011233432103","article-title":"Comparison of upper GI toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis","volume":"343","author":"Bombadier","year":"2000","journal-title":"N Engl J Med"},{"key":"2023042416515417200_R5","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1001\/jama.286.8.954","article-title":"Risk of cardiovascular events associated with selective COX-2 inhibitors","volume":"286","author":"Mukherjee","year":"2001","journal-title":"JAMA"},{"key":"2023042416515417200_R6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0009-9120(94)90038-8","article-title":"Role of clinical laboratory in allergy testing","volume":"27","author":"Salkie","year":"1994","journal-title":"Clin Biochem"},{"key":"2023042416515417200_R7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1034\/j.1398-9995.1999.00882.x","article-title":"Usefulness of uni CAP-tryptase fluoroimmunoassay in the diagnosis of anaphylaxis","volume":"54","author":"Enrique","year":"1999","journal-title":"Allergy"},{"key":"2023042416515417200_R8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0190-9622(91)70183-3","article-title":"Angioedema: manifestations and management","volume":"25","author":"Greaves","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"2023042416515417200_R9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0190-9622(97)70250-0","article-title":"Acquired angioedema","volume":"36","author":"Heymann","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"2023042416515417200_R10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S1081-1206(10)62412-X","article-title":"Tolerability of meloxicam in patients with histories of adverse reactions to nonsteroidal anti-inflammatory drugs","volume":"84","author":"Quarantino","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2023042416515417200_R11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S1081-1206(10)62457-X","article-title":"Acquired angioedema","volume":"85","author":"Asero","year":"2000","journal-title":"Am Allergy Asthma Immunol"},{"key":"2023042416515417200_R12","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1001\/jama.282.20.1929","article-title":"Adverse upper GI effects of rofecoxib compared with NSAIDs","volume":"282","author":"Langman","year":"1999","journal-title":"JAMA"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/78\/921\/439\/50040548\/postgradmedj-78-439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/78\/921\/439\/50040548\/postgradmedj-78-439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T16:52:06Z","timestamp":1682355126000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/78\/921\/439\/7039210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,1]]},"references-count":12,"journal-issue":{"issue":"921","published-online":{"date-parts":[[2002,7,1]]},"published-print":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pmj.78.921.439","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2002,7]]},"published":{"date-parts":[[2002,7,1]]}}}