{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:39:07Z","timestamp":1781059147812,"version":"3.54.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"925","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To study the cardiac abnormalities in HIV infected patients in relation to the clinical stage of the disease and the immunological status of the patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total 75 consecutive patients tested for HIV on the basis of clinical suspicion of the disease from July to September 1996 at the University Hospital Centre, Yaounde, Cameroon were recruited. The patients were classified into AIDS, HIV positive non-AIDS, and HIV negative according to clinical findings and outcome of ELISA and western blot testing. Every patient underwent a clinical examination, two dimensional and M-mode echocardiography, and blood lymphocyte typing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Dilated cardiomyopathy occurred in 7\/30 (23.33%) AIDS patients, 1\/24 (4.17%) HIV positive non-AIDS patient, but in none of the HIV negative patients. Other echocardiographic abnormalities included pericardial separation, effusion, thickening, and mitral valve prolapse. Although these abnormalities were more frequent in HIV infected patients, the differences did not reach levels of statistical significance. Dilated cardiomyopathy occurred in six (31.58%) of the patients with a CD4 cell count \u2264100\/mm3 and two (6.06%) in those with absolute CD4 counts &amp;gt;100\/mm3 (\u03c72 = 4.02, p = 0.03).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cardiovascular abnormalities are frequent in African HIV infected patients but clinically discrete. Low CD4 cell counts are associated with dilated cardiomyopathy. These abnormalities should be expected with greater frequency in cardiological clinical practice as management of opportunistic infections improves in a situation of continued high disease prevalence in Africa.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/pmj.78.925.678","type":"journal-article","created":{"date-parts":[[2002,12,20]],"date-time":"2002-12-20T17:44:09Z","timestamp":1040406249000},"page":"678-681","source":"Crossref","is-referenced-by-count":32,"title":["Cardiac involvement in HIV infected people in Yaounde, Cameroon"],"prefix":"10.1093","volume":"78","author":[{"given":"D","family":"Nzuobontane","sequence":"first","affiliation":[{"name":"Wirral Hospital Trust, St Catherine\u2019s Hospital , Birkenhead, Merseyside , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K N","family":"Blackett","sequence":"additional","affiliation":[{"name":"University Hospital Centre, Faculty of Medicine and Biomedical Sciences , Yaounde , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kuaban","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences, University of Yaounde 1 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"2023042418011691500_R1","volume-title":"Epidemiological factsheets on HIV and sexually transmissible diseases, Cameroon","author":"UNAIDS","year":"2000"},{"key":"2023042418011691500_R2","volume-title":"AIDS control execution manual","author":"National AIDS Commission, Ministry of Public Health","year":"2001"},{"key":"2023042418011691500_R3","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/0735-1097(89)90256-8","article-title":"Cardiac manifestations of human immunodeficiency virus infection: a two dimensional echocardiography study","volume":"13","author":"Himelman","year":"1989","journal-title":"J Am Coll Cardiol"},{"key":"2023042418011691500_R4","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0002-9149(93)90913-W","article-title":"Prevalence and Incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection","volume":"15","author":"Herskowitz","year":"1993","journal-title":"Am J Cardiol"},{"key":"2023042418011691500_R5","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1136\/bmj.309.6969.1605","article-title":"Heart muscle disease related to HIV infection; prognostic implications","volume":"390","author":"Curie","year":"1994","journal-title":"BMJ"},{"key":"2023042418011691500_R6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1056\/NEJM199903043400911","article-title":"Dilated cardiomyopathy in HIV patients","volume":"340","author":"Chariot","year":"1999","journal-title":"N Engl J Med"},{"key":"2023042418011691500_R7","first-page":"33","article-title":"Malnutrition and cardiac abnormalities","volume-title":"HIV infected patients. 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